| Full name: tubulin tyrosine ligase like 3 | Alias Symbol: DKFZP434B103|HOTTL | ||
| Type: protein-coding gene | Cytoband: 3p25.3 | ||
| Entrez ID: 26140 | HGNC ID: HGNC:24483 | Ensembl Gene: ENSG00000214021 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of TTLL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTLL3 | 26140 | 230873_at | -0.1611 | 0.6098 | |
| GSE26886 | TTLL3 | 26140 | 230873_at | -0.0654 | 0.6508 | |
| GSE45670 | TTLL3 | 26140 | 230873_at | -0.3050 | 0.0084 | |
| GSE53622 | TTLL3 | 26140 | 145620 | -0.2396 | 0.0010 | |
| GSE53624 | TTLL3 | 26140 | 145620 | -0.1103 | 0.1827 | |
| GSE63941 | TTLL3 | 26140 | 230873_at | -0.6570 | 0.0085 | |
| GSE77861 | TTLL3 | 26140 | 230873_at | -0.1990 | 0.0633 | |
| SRP064894 | TTLL3 | 26140 | RNAseq | -0.1238 | 0.6594 | |
| SRP133303 | TTLL3 | 26140 | RNAseq | -0.8032 | 0.0000 | |
| SRP159526 | TTLL3 | 26140 | RNAseq | -0.9477 | 0.0000 | |
| SRP193095 | TTLL3 | 26140 | RNAseq | -0.4379 | 0.0020 | |
| SRP219564 | TTLL3 | 26140 | RNAseq | -0.7339 | 0.1019 | |
| TCGA | TTLL3 | 26140 | RNAseq | -0.3876 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TTLL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTLL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTLL3 | 26140 | 1 | 18 | 11 | |
| GSE20123 | TTLL3 | 26140 | 1 | 18 | 11 | |
| GSE43470 | TTLL3 | 26140 | 1 | 20 | 22 | |
| GSE46452 | TTLL3 | 26140 | 2 | 17 | 40 | |
| GSE47630 | TTLL3 | 26140 | 3 | 22 | 15 | |
| GSE54993 | TTLL3 | 26140 | 6 | 1 | 63 | |
| GSE54994 | TTLL3 | 26140 | 3 | 31 | 19 | |
| GSE60625 | TTLL3 | 26140 | 5 | 0 | 6 | |
| GSE74703 | TTLL3 | 26140 | 1 | 16 | 19 | |
| GSE74704 | TTLL3 | 26140 | 1 | 11 | 8 | |
| TCGA | TTLL3 | 26140 | 5 | 65 | 26 |
Total number of gains: 29; Total number of losses: 219; Total Number of normals: 240.
Somatic mutations of TTLL3:
Generating mutation plots.
Highly correlated genes for TTLL3:
Showing top 20/94 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTLL3 | DDC | 0.761842 | 3 | 0 | 3 |
| TTLL3 | SEC31A | 0.733113 | 3 | 0 | 3 |
| TTLL3 | TMEM234 | 0.714106 | 3 | 0 | 3 |
| TTLL3 | MFSD5 | 0.708808 | 3 | 0 | 3 |
| TTLL3 | CUL3 | 0.704349 | 3 | 0 | 3 |
| TTLL3 | MFSD1 | 0.691146 | 3 | 0 | 3 |
| TTLL3 | DNTT | 0.666498 | 3 | 0 | 3 |
| TTLL3 | VILL | 0.666192 | 3 | 0 | 3 |
| TTLL3 | ZNF436 | 0.663148 | 3 | 0 | 3 |
| TTLL3 | TMEM9B | 0.654813 | 3 | 0 | 3 |
| TTLL3 | ARF6 | 0.648322 | 3 | 0 | 3 |
| TTLL3 | GLCE | 0.639036 | 3 | 0 | 3 |
| TTLL3 | TAB2 | 0.632511 | 3 | 0 | 3 |
| TTLL3 | ACYP2 | 0.63196 | 4 | 0 | 4 |
| TTLL3 | YPEL3 | 0.629951 | 3 | 0 | 3 |
| TTLL3 | ZNF665 | 0.626281 | 3 | 0 | 3 |
| TTLL3 | TAAR5 | 0.623737 | 3 | 0 | 3 |
| TTLL3 | ZNF880 | 0.621228 | 3 | 0 | 3 |
| TTLL3 | TRIM8 | 0.616108 | 3 | 0 | 3 |
| TTLL3 | TRIM41 | 0.615869 | 3 | 0 | 3 |
For details and further investigation, click here
