| Full name: WD repeat domain 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 11180 | HGNC ID: HGNC:12758 | Ensembl Gene: ENSG00000178252 | OMIM ID: 606031 |
| Drug and gene relationship at DGIdb | |||
Expression of WDR6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WDR6 | 11180 | 217734_s_at | 0.0849 | 0.8952 | |
| GSE20347 | WDR6 | 11180 | 217734_s_at | 0.2817 | 0.0691 | |
| GSE23400 | WDR6 | 11180 | 217734_s_at | 0.0954 | 0.2574 | |
| GSE26886 | WDR6 | 11180 | 217734_s_at | 0.7421 | 0.0014 | |
| GSE29001 | WDR6 | 11180 | 217734_s_at | 0.3434 | 0.5151 | |
| GSE38129 | WDR6 | 11180 | 217734_s_at | 0.0603 | 0.7320 | |
| GSE45670 | WDR6 | 11180 | 217734_s_at | -0.0903 | 0.4865 | |
| GSE53622 | WDR6 | 11180 | 37066 | -0.3713 | 0.0000 | |
| GSE53624 | WDR6 | 11180 | 27851 | -0.1924 | 0.0007 | |
| GSE63941 | WDR6 | 11180 | 217734_s_at | -0.3802 | 0.2183 | |
| GSE77861 | WDR6 | 11180 | 217734_s_at | 0.1608 | 0.4224 | |
| GSE97050 | WDR6 | 11180 | A_33_P3815560 | -0.2146 | 0.3734 | |
| SRP007169 | WDR6 | 11180 | RNAseq | 0.1858 | 0.6725 | |
| SRP008496 | WDR6 | 11180 | RNAseq | 0.4184 | 0.1840 | |
| SRP064894 | WDR6 | 11180 | RNAseq | 0.1470 | 0.3762 | |
| SRP133303 | WDR6 | 11180 | RNAseq | -0.4483 | 0.0007 | |
| SRP159526 | WDR6 | 11180 | RNAseq | -0.1858 | 0.4991 | |
| SRP193095 | WDR6 | 11180 | RNAseq | 0.0335 | 0.7825 | |
| SRP219564 | WDR6 | 11180 | RNAseq | -0.0412 | 0.9180 | |
| TCGA | WDR6 | 11180 | RNAseq | -0.1897 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by WDR6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WDR6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WDR6 | 11180 | 0 | 18 | 12 | |
| GSE20123 | WDR6 | 11180 | 0 | 19 | 11 | |
| GSE43470 | WDR6 | 11180 | 0 | 18 | 25 | |
| GSE46452 | WDR6 | 11180 | 2 | 16 | 41 | |
| GSE47630 | WDR6 | 11180 | 1 | 24 | 15 | |
| GSE54993 | WDR6 | 11180 | 6 | 2 | 62 | |
| GSE54994 | WDR6 | 11180 | 0 | 36 | 17 | |
| GSE60625 | WDR6 | 11180 | 5 | 0 | 6 | |
| GSE74703 | WDR6 | 11180 | 0 | 14 | 22 | |
| GSE74704 | WDR6 | 11180 | 0 | 12 | 8 | |
| TCGA | WDR6 | 11180 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of WDR6:
Generating mutation plots.
Highly correlated genes for WDR6:
Showing top 20/129 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WDR6 | HOXC9 | 0.740134 | 3 | 0 | 3 |
| WDR6 | ZBTB24 | 0.72485 | 3 | 0 | 3 |
| WDR6 | PNMA6A | 0.721424 | 3 | 0 | 3 |
| WDR6 | FBRSL1 | 0.684779 | 4 | 0 | 4 |
| WDR6 | COPS7B | 0.678627 | 3 | 0 | 3 |
| WDR6 | TELO2 | 0.660993 | 3 | 0 | 3 |
| WDR6 | APBA3 | 0.64634 | 3 | 0 | 3 |
| WDR6 | TBX3 | 0.645885 | 4 | 0 | 3 |
| WDR6 | NBR2 | 0.645173 | 3 | 0 | 3 |
| WDR6 | CTBP1 | 0.638086 | 4 | 0 | 4 |
| WDR6 | DOHH | 0.635229 | 5 | 0 | 3 |
| WDR6 | ZNF77 | 0.632405 | 3 | 0 | 3 |
| WDR6 | DNLZ | 0.628663 | 3 | 0 | 3 |
| WDR6 | SIGIRR | 0.627186 | 6 | 0 | 5 |
| WDR6 | NPR2 | 0.624334 | 4 | 0 | 3 |
| WDR6 | PMEPA1 | 0.619734 | 4 | 0 | 3 |
| WDR6 | PKD1 | 0.617964 | 4 | 0 | 3 |
| WDR6 | OBSL1 | 0.61318 | 5 | 0 | 4 |
| WDR6 | BMPR1B | 0.610868 | 5 | 0 | 4 |
| WDR6 | SEC62 | 0.607315 | 6 | 0 | 4 |
For details and further investigation, click here
