POLR1E

 

Full name: RNA polymerase I subunit E Alias Symbol: FLJ13390|PAF53|FLJ13970
Type: protein-coding gene Cytoband: 9p13.2
Entrez ID: 64425 HGNC ID: HGNC:17631 Ensembl Gene: ENSG00000137054 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of POLR1E:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POLR1E 64425 218997_at 0.0439 0.9134
GSE20347 POLR1E 64425 218997_at 0.0528 0.7813
GSE23400 POLR1E 64425 218997_at 0.0987 0.1879
GSE26886 POLR1E 64425 218997_at 0.3088 0.2226
GSE29001 POLR1E 64425 218997_at 0.0839 0.7685
GSE38129 POLR1E 64425 218997_at 0.0645 0.6033
GSE45670 POLR1E 64425 218997_at -0.2150 0.0654
GSE53622 POLR1E 64425 13396 0.0143 0.8891
GSE53624 POLR1E 64425 13396 0.2919 0.0111
GSE63941 POLR1E 64425 218997_at -0.0397 0.9412
GSE77861 POLR1E 64425 218997_at -0.1744 0.4287
GSE97050 POLR1E A_21_P0006008 -0.3035 0.3996
SRP007169 POLR1E 64425 RNAseq 0.2800 0.4889
SRP008496 POLR1E 64425 RNAseq 0.5939 0.0432
SRP064894 POLR1E 64425 RNAseq 0.1286 0.5007
SRP133303 POLR1E 64425 RNAseq -0.2612 0.0971
SRP159526 POLR1E 64425 RNAseq -0.2630 0.4570
SRP193095 POLR1E 64425 RNAseq -0.0736 0.5994
SRP219564 POLR1E 64425 RNAseq 0.1013 0.7690
TCGA POLR1E 64425 RNAseq 0.0380 0.5646

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by POLR1E expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POLR1E:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POLR1E 64425 4 13 13
GSE20123 POLR1E 64425 4 13 13
GSE43470 POLR1E 64425 1 12 30
GSE46452 POLR1E 64425 6 15 38
GSE47630 POLR1E 64425 1 20 19
GSE54993 POLR1E 64425 6 0 64
GSE54994 POLR1E 64425 5 13 35
GSE60625 POLR1E 64425 0 0 11
GSE74703 POLR1E 64425 1 8 27
GSE74704 POLR1E 64425 1 9 10
TCGA POLR1E 64425 14 44 38

Total number of gains: 43; Total number of losses: 147; Total Number of normals: 298.  

 

Somatic mutations of POLR1E:

 

Generating mutation plots.

 

Highly correlated genes for POLR1E:

 

Showing all 8 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POLR1ECCDC1060.670181303
POLR1EZNF2390.581327603
POLR1EGALT0.571447504
POLR1ECNTN50.559748303
POLR1EMEP1A0.536303
POLR1EMGAM0.535191303
POLR1EONECUT10.532683303
POLR1ESYT30.517843403

For details and further investigation, click here