| Full name: one cut homeobox 1 | Alias Symbol: HNF-6 | ||
| Type: protein-coding gene | Cytoband: 15q21.3 | ||
| Entrez ID: 3175 | HGNC ID: HGNC:8138 | Ensembl Gene: ENSG00000169856 | OMIM ID: 604164 |
| Drug and gene relationship at DGIdb | |||
ONECUT1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04950 | Maturity onset diabetes of the young |
Expression of ONECUT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ONECUT1 | 3175 | 210745_at | -0.0758 | 0.8123 | |
| GSE20347 | ONECUT1 | 3175 | 210745_at | -0.0122 | 0.8653 | |
| GSE23400 | ONECUT1 | 3175 | 210745_at | -0.1046 | 0.0012 | |
| GSE26886 | ONECUT1 | 3175 | 210745_at | -0.1906 | 0.0508 | |
| GSE29001 | ONECUT1 | 3175 | 210745_at | -0.1104 | 0.3626 | |
| GSE38129 | ONECUT1 | 3175 | 210745_at | -0.1037 | 0.0446 | |
| GSE45670 | ONECUT1 | 3175 | 210745_at | 0.0055 | 0.9583 | |
| GSE53622 | ONECUT1 | 3175 | 87594 | 0.3438 | 0.0001 | |
| GSE53624 | ONECUT1 | 3175 | 87594 | 0.0015 | 0.9924 | |
| GSE63941 | ONECUT1 | 3175 | 210745_at | -0.0834 | 0.5205 | |
| GSE77861 | ONECUT1 | 3175 | 210745_at | -0.1700 | 0.0965 | |
| GSE97050 | ONECUT1 | 3175 | A_23_P340717 | 0.2815 | 0.2937 | |
| SRP133303 | ONECUT1 | 3175 | RNAseq | -0.0252 | 0.9013 | |
| TCGA | ONECUT1 | 3175 | RNAseq | 2.7836 | 0.0034 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ONECUT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ONECUT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ONECUT1 | 3175 | 6 | 3 | 21 | |
| GSE20123 | ONECUT1 | 3175 | 6 | 3 | 21 | |
| GSE43470 | ONECUT1 | 3175 | 4 | 3 | 36 | |
| GSE46452 | ONECUT1 | 3175 | 3 | 7 | 49 | |
| GSE47630 | ONECUT1 | 3175 | 8 | 10 | 22 | |
| GSE54993 | ONECUT1 | 3175 | 5 | 6 | 59 | |
| GSE54994 | ONECUT1 | 3175 | 5 | 7 | 41 | |
| GSE60625 | ONECUT1 | 3175 | 4 | 0 | 7 | |
| GSE74703 | ONECUT1 | 3175 | 4 | 2 | 30 | |
| GSE74704 | ONECUT1 | 3175 | 2 | 3 | 15 | |
| TCGA | ONECUT1 | 3175 | 9 | 17 | 70 |
Total number of gains: 56; Total number of losses: 61; Total Number of normals: 371.
Somatic mutations of ONECUT1:
Generating mutation plots.
Highly correlated genes for ONECUT1:
Showing top 20/622 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ONECUT1 | TP73 | 0.740809 | 3 | 0 | 3 |
| ONECUT1 | CCDC87 | 0.73316 | 3 | 0 | 3 |
| ONECUT1 | SP6 | 0.704457 | 3 | 0 | 3 |
| ONECUT1 | KLHL10 | 0.704048 | 3 | 0 | 3 |
| ONECUT1 | SP7 | 0.703957 | 3 | 0 | 3 |
| ONECUT1 | CPN1 | 0.699826 | 4 | 0 | 3 |
| ONECUT1 | ZGLP1 | 0.696348 | 4 | 0 | 4 |
| ONECUT1 | SV2C | 0.695746 | 4 | 0 | 3 |
| ONECUT1 | PRKAG3 | 0.689343 | 3 | 0 | 3 |
| ONECUT1 | LRIT1 | 0.686972 | 4 | 0 | 3 |
| ONECUT1 | NPPA | 0.685064 | 4 | 0 | 3 |
| ONECUT1 | PHOSPHO1 | 0.683926 | 4 | 0 | 3 |
| ONECUT1 | ACR | 0.682227 | 5 | 0 | 5 |
| ONECUT1 | RNF157 | 0.677689 | 4 | 0 | 4 |
| ONECUT1 | OR2H2 | 0.677022 | 5 | 0 | 4 |
| ONECUT1 | ATPAF2 | 0.675443 | 3 | 0 | 3 |
| ONECUT1 | CRTAC1 | 0.67543 | 3 | 0 | 3 |
| ONECUT1 | GBA3 | 0.675064 | 4 | 0 | 3 |
| ONECUT1 | C4BPA | 0.67444 | 4 | 0 | 3 |
| ONECUT1 | LRRC71 | 0.674306 | 3 | 0 | 3 |
For details and further investigation, click here
