| Full name: meprin A subunit alpha | Alias Symbol: PPHA | ||
| Type: protein-coding gene | Cytoband: 6p12.3 | ||
| Entrez ID: 4224 | HGNC ID: HGNC:7015 | Ensembl Gene: ENSG00000112818 | OMIM ID: 600388 |
| Drug and gene relationship at DGIdb | |||
Expression of MEP1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MEP1A | 4224 | 206000_at | 0.0758 | 0.8557 | |
| GSE20347 | MEP1A | 4224 | 206000_at | 0.0367 | 0.6403 | |
| GSE23400 | MEP1A | 4224 | 206000_at | -0.0874 | 0.0230 | |
| GSE26886 | MEP1A | 4224 | 206000_at | 0.1054 | 0.5864 | |
| GSE29001 | MEP1A | 4224 | 206000_at | 0.0557 | 0.7261 | |
| GSE38129 | MEP1A | 4224 | 206000_at | 0.0262 | 0.7315 | |
| GSE45670 | MEP1A | 4224 | 206000_at | 0.1608 | 0.0777 | |
| GSE53622 | MEP1A | 4224 | 53567 | 0.3705 | 0.0091 | |
| GSE53624 | MEP1A | 4224 | 53567 | 0.7443 | 0.0000 | |
| GSE63941 | MEP1A | 4224 | 206000_at | 0.0021 | 0.9894 | |
| GSE77861 | MEP1A | 4224 | 206000_at | -0.1137 | 0.1870 | |
| GSE97050 | MEP1A | 4224 | A_24_P154868 | 0.1733 | 0.3888 | |
| TCGA | MEP1A | 4224 | RNAseq | 1.3042 | 0.0411 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MEP1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MEP1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MEP1A | 4224 | 6 | 2 | 22 | |
| GSE20123 | MEP1A | 4224 | 6 | 2 | 22 | |
| GSE43470 | MEP1A | 4224 | 5 | 0 | 38 | |
| GSE46452 | MEP1A | 4224 | 2 | 10 | 47 | |
| GSE47630 | MEP1A | 4224 | 7 | 5 | 28 | |
| GSE54993 | MEP1A | 4224 | 3 | 1 | 66 | |
| GSE54994 | MEP1A | 4224 | 8 | 3 | 42 | |
| GSE60625 | MEP1A | 4224 | 0 | 3 | 8 | |
| GSE74703 | MEP1A | 4224 | 5 | 0 | 31 | |
| GSE74704 | MEP1A | 4224 | 2 | 1 | 17 | |
| TCGA | MEP1A | 4224 | 18 | 14 | 64 |
Total number of gains: 62; Total number of losses: 41; Total Number of normals: 385.
Somatic mutations of MEP1A:
Generating mutation plots.
Highly correlated genes for MEP1A:
Showing top 20/504 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MEP1A | FBLN7 | 0.798895 | 3 | 0 | 3 |
| MEP1A | SYT3 | 0.778462 | 3 | 0 | 3 |
| MEP1A | OR4A15 | 0.769712 | 3 | 0 | 3 |
| MEP1A | PRAMEF5 | 0.750742 | 3 | 0 | 3 |
| MEP1A | ALAS2 | 0.748148 | 3 | 0 | 3 |
| MEP1A | TRIM43 | 0.740201 | 3 | 0 | 3 |
| MEP1A | PGC | 0.738805 | 3 | 0 | 3 |
| MEP1A | SMC1B | 0.736462 | 3 | 0 | 3 |
| MEP1A | OR4F21 | 0.731259 | 3 | 0 | 3 |
| MEP1A | GLYATL1 | 0.729517 | 3 | 0 | 3 |
| MEP1A | OR2D2 | 0.727123 | 3 | 0 | 3 |
| MEP1A | CLRN1-AS1 | 0.720779 | 3 | 0 | 3 |
| MEP1A | GGTLC1 | 0.720537 | 3 | 0 | 3 |
| MEP1A | B3GALT1 | 0.711047 | 4 | 0 | 4 |
| MEP1A | SLC22A31 | 0.709735 | 4 | 0 | 3 |
| MEP1A | HK3 | 0.704476 | 4 | 0 | 3 |
| MEP1A | SV2C | 0.70151 | 3 | 0 | 3 |
| MEP1A | DNAJC5B | 0.699216 | 4 | 0 | 4 |
| MEP1A | CRYGA | 0.694984 | 3 | 0 | 3 |
| MEP1A | UROC1 | 0.68936 | 3 | 0 | 3 |
For details and further investigation, click here
