POU5F1

 

Full name: POU class 5 homeobox 1 Alias Symbol: OCT3|Oct4|MGC22487
Type: protein-coding gene Cytoband: 6p21.33
Entrez ID: 5460 HGNC ID: HGNC:9221 Ensembl Gene: ENSG00000204531 OMIM ID: 164177
Related drugs: ALCOHOL... [more]
Screen Evidence:

 

POU5F1 involved pathways:

KEGG pathway Description View
hsa04550Signaling pathways regulating pluripotency of stem cells

 

Expression of POU5F1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 POU5F1 5460 67477 -0.1760 0.1636
GSE53624 POU5F1 5460 65606 0.7333 0.0000
GSE97050 POU5F1 5460 A_23_P59138 0.2044 0.4051
SRP064894 POU5F1 5460 RNAseq 1.4233 0.0007
SRP133303 POU5F1 5460 RNAseq 0.2400 0.2893
SRP159526 POU5F1 5460 RNAseq 1.2258 0.0325
SRP193095 POU5F1 5460 RNAseq 0.6431 0.0008
SRP219564 POU5F1 5460 RNAseq 1.0425 0.2893
TCGA POU5F1 5460 RNAseq -0.9770 0.0007

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by POU5F1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POU5F1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POU5F1 5460 5 1 24
GSE20123 POU5F1 5460 5 1 24
GSE43470 POU5F1 5460 5 1 37
GSE46452 POU5F1 5460 1 10 48
GSE47630 POU5F1 5460 7 3 30
GSE54993 POU5F1 5460 2 1 67
GSE54994 POU5F1 5460 11 4 38
GSE60625 POU5F1 5460 0 1 10
GSE74703 POU5F1 5460 5 0 31
GSE74704 POU5F1 5460 2 0 18
TCGA POU5F1 5460 17 16 63

Total number of gains: 60; Total number of losses: 38; Total Number of normals: 390.  

 

Somatic mutations of POU5F1:

 

Generating mutation plots.

 

Highly correlated genes for POU5F1:

 

Showing all 8 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POU5F1TAS2R300.720144303
POU5F1KCNQ40.672495303
POU5F1TBC1D10.657872303
POU5F1FAM181B0.65733303
POU5F1FAM131A0.624752303
POU5F1DNAH90.577633403
POU5F1PTAFR0.57066403
POU5F1NLGN20.567857303

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