| Full name: POU class 5 homeobox 1 | Alias Symbol: OCT3|Oct4|MGC22487 | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 5460 | HGNC ID: HGNC:9221 | Ensembl Gene: ENSG00000204531 | OMIM ID: 164177 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
POU5F1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of POU5F1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | POU5F1 | 5460 | 67477 | -0.1760 | 0.1636 | |
| GSE53624 | POU5F1 | 5460 | 65606 | 0.7333 | 0.0000 | |
| GSE97050 | POU5F1 | 5460 | A_23_P59138 | 0.2044 | 0.4051 | |
| SRP064894 | POU5F1 | 5460 | RNAseq | 1.4233 | 0.0007 | |
| SRP133303 | POU5F1 | 5460 | RNAseq | 0.2400 | 0.2893 | |
| SRP159526 | POU5F1 | 5460 | RNAseq | 1.2258 | 0.0325 | |
| SRP193095 | POU5F1 | 5460 | RNAseq | 0.6431 | 0.0008 | |
| SRP219564 | POU5F1 | 5460 | RNAseq | 1.0425 | 0.2893 | |
| TCGA | POU5F1 | 5460 | RNAseq | -0.9770 | 0.0007 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by POU5F1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POU5F1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POU5F1 | 5460 | 5 | 1 | 24 | |
| GSE20123 | POU5F1 | 5460 | 5 | 1 | 24 | |
| GSE43470 | POU5F1 | 5460 | 5 | 1 | 37 | |
| GSE46452 | POU5F1 | 5460 | 1 | 10 | 48 | |
| GSE47630 | POU5F1 | 5460 | 7 | 3 | 30 | |
| GSE54993 | POU5F1 | 5460 | 2 | 1 | 67 | |
| GSE54994 | POU5F1 | 5460 | 11 | 4 | 38 | |
| GSE60625 | POU5F1 | 5460 | 0 | 1 | 10 | |
| GSE74703 | POU5F1 | 5460 | 5 | 0 | 31 | |
| GSE74704 | POU5F1 | 5460 | 2 | 0 | 18 | |
| TCGA | POU5F1 | 5460 | 17 | 16 | 63 |
Total number of gains: 60; Total number of losses: 38; Total Number of normals: 390.
Somatic mutations of POU5F1:
Generating mutation plots.
Highly correlated genes for POU5F1:
Showing all 8 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POU5F1 | TAS2R30 | 0.720144 | 3 | 0 | 3 |
| POU5F1 | KCNQ4 | 0.672495 | 3 | 0 | 3 |
| POU5F1 | TBC1D1 | 0.657872 | 3 | 0 | 3 |
| POU5F1 | FAM181B | 0.65733 | 3 | 0 | 3 |
| POU5F1 | FAM131A | 0.624752 | 3 | 0 | 3 |
| POU5F1 | DNAH9 | 0.577633 | 4 | 0 | 3 |
| POU5F1 | PTAFR | 0.57066 | 4 | 0 | 3 |
| POU5F1 | NLGN2 | 0.567857 | 3 | 0 | 3 |
For details and further investigation, click here
