| Full name: potassium voltage-gated channel subfamily Q member 4 | Alias Symbol: Kv7.4 | ||
| Type: protein-coding gene | Cytoband: 1p34.2 | ||
| Entrez ID: 9132 | HGNC ID: HGNC:6298 | Ensembl Gene: ENSG00000117013 | OMIM ID: 603537 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNQ4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNQ4 | 9132 | 243209_at | -1.0756 | 0.2020 | |
| GSE20347 | KCNQ4 | 9132 | 221083_at | -0.1881 | 0.0015 | |
| GSE23400 | KCNQ4 | 9132 | 221083_at | -0.1441 | 0.0000 | |
| GSE26886 | KCNQ4 | 9132 | 221083_at | 0.0983 | 0.4878 | |
| GSE29001 | KCNQ4 | 9132 | 221083_at | -0.2214 | 0.0816 | |
| GSE38129 | KCNQ4 | 9132 | 221083_at | -0.2638 | 0.0007 | |
| GSE45670 | KCNQ4 | 9132 | 243209_at | -1.4883 | 0.0000 | |
| GSE53622 | KCNQ4 | 9132 | 120205 | 0.0294 | 0.7506 | |
| GSE53624 | KCNQ4 | 9132 | 120205 | 0.0898 | 0.3418 | |
| GSE63941 | KCNQ4 | 9132 | 221083_at | 0.4028 | 0.0115 | |
| GSE77861 | KCNQ4 | 9132 | 221083_at | -0.1986 | 0.1587 | |
| GSE97050 | KCNQ4 | 9132 | A_23_P34424 | -0.4051 | 0.2828 | |
| SRP064894 | KCNQ4 | 9132 | RNAseq | -1.3538 | 0.0000 | |
| SRP133303 | KCNQ4 | 9132 | RNAseq | -2.1460 | 0.0000 | |
| SRP159526 | KCNQ4 | 9132 | RNAseq | -0.9023 | 0.0359 | |
| SRP219564 | KCNQ4 | 9132 | RNAseq | -0.3952 | 0.6487 | |
| TCGA | KCNQ4 | 9132 | RNAseq | -1.2863 | 0.0022 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by KCNQ4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNQ4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNQ4 | 9132 | 3 | 4 | 23 | |
| GSE20123 | KCNQ4 | 9132 | 2 | 3 | 25 | |
| GSE43470 | KCNQ4 | 9132 | 7 | 2 | 34 | |
| GSE46452 | KCNQ4 | 9132 | 3 | 1 | 55 | |
| GSE47630 | KCNQ4 | 9132 | 9 | 2 | 29 | |
| GSE54993 | KCNQ4 | 9132 | 0 | 1 | 69 | |
| GSE54994 | KCNQ4 | 9132 | 13 | 2 | 38 | |
| GSE60625 | KCNQ4 | 9132 | 0 | 0 | 11 | |
| GSE74703 | KCNQ4 | 9132 | 6 | 1 | 29 | |
| GSE74704 | KCNQ4 | 9132 | 1 | 0 | 19 | |
| TCGA | KCNQ4 | 9132 | 16 | 16 | 64 |
Total number of gains: 60; Total number of losses: 32; Total Number of normals: 396.
Somatic mutations of KCNQ4:
Generating mutation plots.
Highly correlated genes for KCNQ4:
Showing top 20/929 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNQ4 | YY2 | 0.86611 | 3 | 0 | 3 |
| KCNQ4 | OR2T1 | 0.852517 | 3 | 0 | 3 |
| KCNQ4 | PRSS38 | 0.838901 | 3 | 0 | 3 |
| KCNQ4 | OR2B11 | 0.828216 | 3 | 0 | 3 |
| KCNQ4 | DCDC1 | 0.827271 | 3 | 0 | 3 |
| KCNQ4 | PGC | 0.821099 | 3 | 0 | 3 |
| KCNQ4 | OTOG | 0.819083 | 3 | 0 | 3 |
| KCNQ4 | BBC3 | 0.812846 | 3 | 0 | 3 |
| KCNQ4 | OR2A5 | 0.807985 | 3 | 0 | 3 |
| KCNQ4 | OR10AD1 | 0.804447 | 3 | 0 | 3 |
| KCNQ4 | CATSPER3 | 0.801711 | 3 | 0 | 3 |
| KCNQ4 | MRGPRG | 0.801471 | 3 | 0 | 3 |
| KCNQ4 | STRC | 0.794863 | 3 | 0 | 3 |
| KCNQ4 | C19orf71 | 0.791306 | 3 | 0 | 3 |
| KCNQ4 | PLA2G2C | 0.788015 | 3 | 0 | 3 |
| KCNQ4 | OR2T27 | 0.787956 | 3 | 0 | 3 |
| KCNQ4 | GDF7 | 0.786156 | 3 | 0 | 3 |
| KCNQ4 | C1QL2 | 0.78418 | 3 | 0 | 3 |
| KCNQ4 | KRTAP10-12 | 0.780877 | 3 | 0 | 3 |
| KCNQ4 | DMGDH | 0.780067 | 5 | 0 | 5 |
For details and further investigation, click here
