| Full name: TBC1 domain family member 1 | Alias Symbol: TBC|TBC1|KIAA1108 | ||
| Type: protein-coding gene | Cytoband: 4p14 | ||
| Entrez ID: 23216 | HGNC ID: HGNC:11578 | Ensembl Gene: ENSG00000065882 | OMIM ID: 609850 |
| Drug and gene relationship at DGIdb | |||
TBC1D1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway |
Expression of TBC1D1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBC1D1 | 23216 | 212350_at | 0.1399 | 0.9010 | |
| GSE20347 | TBC1D1 | 23216 | 212350_at | 0.3988 | 0.0104 | |
| GSE23400 | TBC1D1 | 23216 | 212350_at | -0.0124 | 0.9078 | |
| GSE26886 | TBC1D1 | 23216 | 212350_at | 0.9988 | 0.0004 | |
| GSE29001 | TBC1D1 | 23216 | 212350_at | 0.4056 | 0.1744 | |
| GSE38129 | TBC1D1 | 23216 | 212350_at | -0.0424 | 0.8907 | |
| GSE45670 | TBC1D1 | 23216 | 212350_at | -0.3733 | 0.1086 | |
| GSE53622 | TBC1D1 | 23216 | 76254 | 0.1951 | 0.1211 | |
| GSE53624 | TBC1D1 | 23216 | 76254 | 0.4342 | 0.0000 | |
| GSE63941 | TBC1D1 | 23216 | 212350_at | 0.5062 | 0.4424 | |
| GSE77861 | TBC1D1 | 23216 | 212350_at | 0.3757 | 0.2908 | |
| GSE97050 | TBC1D1 | 23216 | A_33_P3370812 | -0.3575 | 0.1947 | |
| SRP007169 | TBC1D1 | 23216 | RNAseq | 1.7651 | 0.0000 | |
| SRP008496 | TBC1D1 | 23216 | RNAseq | 1.9959 | 0.0000 | |
| SRP064894 | TBC1D1 | 23216 | RNAseq | 0.9086 | 0.0023 | |
| SRP133303 | TBC1D1 | 23216 | RNAseq | 0.1104 | 0.6992 | |
| SRP159526 | TBC1D1 | 23216 | RNAseq | 0.5211 | 0.2300 | |
| SRP193095 | TBC1D1 | 23216 | RNAseq | 0.5314 | 0.0022 | |
| SRP219564 | TBC1D1 | 23216 | RNAseq | -0.1783 | 0.8138 | |
| TCGA | TBC1D1 | 23216 | RNAseq | -0.2455 | 0.0038 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TBC1D1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBC1D1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBC1D1 | 23216 | 0 | 16 | 14 | |
| GSE20123 | TBC1D1 | 23216 | 0 | 16 | 14 | |
| GSE43470 | TBC1D1 | 23216 | 2 | 13 | 28 | |
| GSE46452 | TBC1D1 | 23216 | 1 | 36 | 22 | |
| GSE47630 | TBC1D1 | 23216 | 1 | 19 | 20 | |
| GSE54993 | TBC1D1 | 23216 | 8 | 0 | 62 | |
| GSE54994 | TBC1D1 | 23216 | 4 | 10 | 39 | |
| GSE60625 | TBC1D1 | 23216 | 0 | 0 | 11 | |
| GSE74703 | TBC1D1 | 23216 | 1 | 11 | 24 | |
| GSE74704 | TBC1D1 | 23216 | 0 | 9 | 11 | |
| TCGA | TBC1D1 | 23216 | 11 | 45 | 40 |
Total number of gains: 28; Total number of losses: 175; Total Number of normals: 285.
Somatic mutations of TBC1D1:
Generating mutation plots.
Highly correlated genes for TBC1D1:
Showing top 20/242 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBC1D1 | USP51 | 0.792049 | 3 | 0 | 3 |
| TBC1D1 | TRIM10 | 0.791796 | 3 | 0 | 3 |
| TBC1D1 | KRTAP3-1 | 0.757079 | 3 | 0 | 3 |
| TBC1D1 | ZNF527 | 0.750631 | 3 | 0 | 3 |
| TBC1D1 | FBRSL1 | 0.740481 | 3 | 0 | 3 |
| TBC1D1 | TNFAIP8L1 | 0.731293 | 4 | 0 | 3 |
| TBC1D1 | FSIP1 | 0.728909 | 3 | 0 | 3 |
| TBC1D1 | BMF | 0.712003 | 5 | 0 | 5 |
| TBC1D1 | CARNS1 | 0.694793 | 3 | 0 | 3 |
| TBC1D1 | PCDH10 | 0.691291 | 3 | 0 | 3 |
| TBC1D1 | MPDZ | 0.684024 | 10 | 0 | 10 |
| TBC1D1 | GRK4 | 0.679551 | 3 | 0 | 3 |
| TBC1D1 | ZMYND15 | 0.679478 | 3 | 0 | 3 |
| TBC1D1 | SMIM8 | 0.668716 | 3 | 0 | 3 |
| TBC1D1 | FAM171A1 | 0.668159 | 4 | 0 | 3 |
| TBC1D1 | LYG1 | 0.667918 | 3 | 0 | 3 |
| TBC1D1 | SLC35G1 | 0.664558 | 4 | 0 | 3 |
| TBC1D1 | POU5F1 | 0.657872 | 3 | 0 | 3 |
| TBC1D1 | PHF21A | 0.65361 | 5 | 0 | 4 |
| TBC1D1 | SHISA4 | 0.650986 | 4 | 0 | 3 |
For details and further investigation, click here
