| Full name: platelet activating factor receptor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p35.3 | ||
| Entrez ID: 5724 | HGNC ID: HGNC:9582 | Ensembl Gene: ENSG00000169403 | OMIM ID: 173393 |
| Drug and gene relationship at DGIdb | |||
PTAFR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa05150 | Staphylococcus aureus infection |
Expression of PTAFR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTAFR | 5724 | 227184_at | 0.5188 | 0.3955 | |
| GSE20347 | PTAFR | 5724 | 211661_x_at | 0.0362 | 0.8113 | |
| GSE23400 | PTAFR | 5724 | 211661_x_at | -0.1042 | 0.0402 | |
| GSE26886 | PTAFR | 5724 | 227184_at | -0.4566 | 0.0652 | |
| GSE29001 | PTAFR | 5724 | 211661_x_at | -0.3605 | 0.0254 | |
| GSE38129 | PTAFR | 5724 | 211661_x_at | 0.0639 | 0.7153 | |
| GSE45670 | PTAFR | 5724 | 227184_at | 0.3459 | 0.1643 | |
| GSE53622 | PTAFR | 5724 | 13952 | 0.1372 | 0.0802 | |
| GSE53624 | PTAFR | 5724 | 13952 | 0.1908 | 0.0261 | |
| GSE63941 | PTAFR | 5724 | 227184_at | 0.5818 | 0.3452 | |
| GSE77861 | PTAFR | 5724 | 227184_at | 0.0408 | 0.8962 | |
| GSE97050 | PTAFR | 5724 | A_33_P3393537 | 0.1098 | 0.5888 | |
| SRP007169 | PTAFR | 5724 | RNAseq | -0.9734 | 0.0848 | |
| SRP008496 | PTAFR | 5724 | RNAseq | -1.1398 | 0.0015 | |
| SRP064894 | PTAFR | 5724 | RNAseq | 0.0719 | 0.7349 | |
| SRP133303 | PTAFR | 5724 | RNAseq | 0.5931 | 0.0084 | |
| SRP159526 | PTAFR | 5724 | RNAseq | -0.6002 | 0.3421 | |
| SRP193095 | PTAFR | 5724 | RNAseq | 0.6856 | 0.0000 | |
| SRP219564 | PTAFR | 5724 | RNAseq | 0.0624 | 0.9115 | |
| TCGA | PTAFR | 5724 | RNAseq | 0.3002 | 0.0423 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PTAFR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTAFR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTAFR | 5724 | 0 | 6 | 24 | |
| GSE20123 | PTAFR | 5724 | 0 | 5 | 25 | |
| GSE43470 | PTAFR | 5724 | 3 | 6 | 34 | |
| GSE46452 | PTAFR | 5724 | 5 | 1 | 53 | |
| GSE47630 | PTAFR | 5724 | 8 | 3 | 29 | |
| GSE54993 | PTAFR | 5724 | 2 | 1 | 67 | |
| GSE54994 | PTAFR | 5724 | 10 | 4 | 39 | |
| GSE60625 | PTAFR | 5724 | 0 | 0 | 11 | |
| GSE74703 | PTAFR | 5724 | 2 | 4 | 30 | |
| GSE74704 | PTAFR | 5724 | 0 | 0 | 20 | |
| TCGA | PTAFR | 5724 | 11 | 23 | 62 |
Total number of gains: 41; Total number of losses: 53; Total Number of normals: 394.
Somatic mutations of PTAFR:
Generating mutation plots.
Highly correlated genes for PTAFR:
Showing top 20/479 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTAFR | STRC | 0.83715 | 3 | 0 | 3 |
| PTAFR | CELF5 | 0.821878 | 3 | 0 | 3 |
| PTAFR | GRIK4 | 0.820933 | 3 | 0 | 3 |
| PTAFR | PLA2G2C | 0.817447 | 3 | 0 | 3 |
| PTAFR | DEFB121 | 0.815398 | 3 | 0 | 3 |
| PTAFR | LHX9 | 0.809505 | 3 | 0 | 3 |
| PTAFR | C9orf153 | 0.797132 | 3 | 0 | 3 |
| PTAFR | SPRED3 | 0.79471 | 3 | 0 | 3 |
| PTAFR | LGALS12 | 0.792935 | 3 | 0 | 3 |
| PTAFR | OR2T27 | 0.791645 | 3 | 0 | 3 |
| PTAFR | YY2 | 0.791183 | 3 | 0 | 3 |
| PTAFR | KRTAP4-8 | 0.7872 | 3 | 0 | 3 |
| PTAFR | MRGPRG | 0.78553 | 3 | 0 | 3 |
| PTAFR | C2CD4D | 0.780479 | 3 | 0 | 3 |
| PTAFR | MYO1A | 0.774869 | 3 | 0 | 3 |
| PTAFR | RBM43 | 0.770264 | 3 | 0 | 3 |
| PTAFR | SEZ6 | 0.767747 | 3 | 0 | 3 |
| PTAFR | ZBTB46 | 0.766493 | 3 | 0 | 3 |
| PTAFR | NRSN1 | 0.766131 | 3 | 0 | 3 |
| PTAFR | QRFP | 0.761269 | 3 | 0 | 3 |
For details and further investigation, click here
