ZAR1

 

Full name: zygote arrest 1 Alias Symbol: Z3CXXC6
Type: protein-coding gene Cytoband: 4p11
Entrez ID: 326340 HGNC ID: HGNC:20436 Ensembl Gene: ENSG00000182223 OMIM ID: 607520
Drug and gene relationship at DGIdb

 

Expression of ZAR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZAR1 326340 1555775_a_at 0.2027 0.6398
GSE26886 ZAR1 326340 1555775_a_at -0.0701 0.5208
GSE45670 ZAR1 326340 1555775_a_at 0.1277 0.1981
GSE53622 ZAR1 326340 36696 -0.0986 0.4224
GSE53624 ZAR1 326340 36696 0.3590 0.0018
GSE63941 ZAR1 326340 1555775_a_at 0.0606 0.6604
GSE77861 ZAR1 326340 1555774_at -0.1125 0.4007
TCGA ZAR1 326340 RNAseq 2.6646 0.0064

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by ZAR1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ZAR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZAR1 326340 1 15 14
GSE20123 ZAR1 326340 1 15 14
GSE43470 ZAR1 326340 0 13 30
GSE46452 ZAR1 326340 1 37 21
GSE47630 ZAR1 326340 1 18 21
GSE54993 ZAR1 326340 7 0 63
GSE54994 ZAR1 326340 4 9 40
GSE60625 ZAR1 326340 0 0 11
GSE74703 ZAR1 326340 0 11 25
GSE74704 ZAR1 326340 0 9 11
TCGA ZAR1 326340 21 34 41

Total number of gains: 36; Total number of losses: 161; Total Number of normals: 291.  

 

Somatic mutations of ZAR1:

 

Generating mutation plots.

 

Highly correlated genes for ZAR1:

 

Showing all 9 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZAR1TTC60.697089303
ZAR1ZIM30.687838303
ZAR1ACTL100.642253303
ZAR1LINC008530.610822303
ZAR1GPATCH30.609832303
ZAR1LINC004850.604282303
ZAR1LRRC450.570238403
ZAR1BTF3L40.56406404
ZAR1SNORA74A0.521685303

For details and further investigation, click here