ZNF454

 

Full name: zinc finger protein 454 Alias Symbol: FLJ37444
Type: protein-coding gene Cytoband: 5q35.3
Entrez ID: 285676 HGNC ID: HGNC:21200 Ensembl Gene: ENSG00000178187 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of ZNF454:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 ZNF454 285676 41852 0.0829 0.7201
GSE53624 ZNF454 285676 41852 0.0614 0.7810
GSE97050 ZNF454 285676 A_23_P144746 -0.0671 0.9489
SRP007169 ZNF454 285676 RNAseq 1.8597 0.0370
SRP064894 ZNF454 285676 RNAseq -0.0695 0.7702
SRP133303 ZNF454 285676 RNAseq -0.0162 0.9268
SRP159526 ZNF454 285676 RNAseq 0.0552 0.8769
SRP193095 ZNF454 285676 RNAseq 0.0744 0.5978
SRP219564 ZNF454 285676 RNAseq 0.6700 0.1770
TCGA ZNF454 285676 RNAseq -1.1787 0.0022

Upregulated datasets: 1; Downregulated datasets: 1.  

 

Survival by ZNF454 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ZNF454:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZNF454 285676 2 13 15
GSE20123 ZNF454 285676 2 13 15
GSE43470 ZNF454 285676 1 11 31
GSE46452 ZNF454 285676 0 27 32
GSE47630 ZNF454 285676 1 20 19
GSE54993 ZNF454 285676 10 2 58
GSE54994 ZNF454 285676 2 17 34
GSE60625 ZNF454 285676 1 0 10
GSE74703 ZNF454 285676 1 7 28
GSE74704 ZNF454 285676 1 6 13
TCGA ZNF454 285676 9 35 52

Total number of gains: 30; Total number of losses: 151; Total Number of normals: 307.  

 

Somatic mutations of ZNF454:

 

Generating mutation plots.

 

Highly correlated genes for ZNF454:

 

Showing all 9 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZNF454DCAF8L20.870324303
ZNF454PRKCB0.859339303
ZNF454MCM90.836967303
ZNF454ZNF6210.829265303
ZNF454SERPINA110.777184303
ZNF454KRBOX10.721526303
ZNF454CST90.720028303
ZNF454FAM186B0.668277303
ZNF454EVC0.602996303

For details and further investigation, click here