PRKCB

 

Full name: protein kinase C beta Alias Symbol: PKCβ
Type: protein-coding gene Cytoband: 16p12.2-p12.1
Entrez ID: 5579 HGNC ID: HGNC:9395 Ensembl Gene: ENSG00000166501 OMIM ID: 176970
Drug and gene relationship at DGIdb

 

PRKCB involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04062Chemokine signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04066HIF-1 signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04530Tight junction
hsa04540Gap junction
hsa04650Natural killer cell mediated cytotoxicity
hsa04662B cell receptor signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa04931Insulin resistance
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04973Carbohydrate digestion and absorption
hsa05031Amphetamine addiction
hsa05032Morphine addiction
hsa05140Leishmaniasis
hsa05161Hepatitis B
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05214Glioma
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of PRKCB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKCB 5579 209685_s_at -0.0770 0.9691
GSE20347 PRKCB 5579 209685_s_at -0.0704 0.7231
GSE23400 PRKCB 5579 209685_s_at -0.2973 0.0006
GSE26886 PRKCB 5579 209685_s_at -0.7201 0.0256
GSE29001 PRKCB 5579 209685_s_at 0.0486 0.8749
GSE38129 PRKCB 5579 209685_s_at -0.6198 0.0577
GSE45670 PRKCB 5579 209685_s_at -0.6873 0.0186
GSE53622 PRKCB 5579 78147 -0.5569 0.0215
GSE53624 PRKCB 5579 78147 -0.7004 0.0003
GSE63941 PRKCB 5579 228795_at -0.0020 0.9932
GSE77861 PRKCB 5579 227824_at 0.0268 0.8428
GSE97050 PRKCB 5579 A_33_P3294533 -0.0611 0.9533
SRP007169 PRKCB 5579 RNAseq 1.5638 0.0645
SRP064894 PRKCB 5579 RNAseq -0.0242 0.9442
SRP133303 PRKCB 5579 RNAseq -0.6160 0.0727
SRP159526 PRKCB 5579 RNAseq -0.7045 0.3754
SRP193095 PRKCB 5579 RNAseq 0.3385 0.2845
SRP219564 PRKCB 5579 RNAseq -0.9013 0.1944
TCGA PRKCB 5579 RNAseq -0.6021 0.0009

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PRKCB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKCB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKCB 5579 5 5 20
GSE20123 PRKCB 5579 5 4 21
GSE43470 PRKCB 5579 4 3 36
GSE46452 PRKCB 5579 38 1 20
GSE47630 PRKCB 5579 11 6 23
GSE54993 PRKCB 5579 3 5 62
GSE54994 PRKCB 5579 4 9 40
GSE60625 PRKCB 5579 4 0 7
GSE74703 PRKCB 5579 4 2 30
GSE74704 PRKCB 5579 3 2 15
TCGA PRKCB 5579 19 13 64

Total number of gains: 100; Total number of losses: 50; Total Number of normals: 338.  

 

Somatic mutations of PRKCB:

 

Generating mutation plots.

 

Highly correlated genes for PRKCB:

 

Showing top 20/170 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKCBZNF4540.859339303
PRKCBDCAF8L20.838094303
PRKCBSERPINA110.761147303
PRKCBFGD50.724293303
PRKCBEVI2A0.721455605
PRKCBCD480.709979907
PRKCBITGB2-AS10.699467303
PRKCBCYTIP0.695504706
PRKCBZNF4440.679007303
PRKCBFREM10.678586303
PRKCBPTPRN20.678428404
PRKCBNLRC30.677025605
PRKCBICAM30.676818605
PRKCBPTGDS0.676118807
PRKCBTP53INP10.672897403
PRKCBCSF2RB0.668442807
PRKCBDOCK20.663269907
PRKCBCD270.661774706
PRKCBTRAT10.659876706
PRKCBCBFA2T30.64399605

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