| Full name: EvC ciliary complex subunit 1 | Alias Symbol: DWF-1 | ||
| Type: protein-coding gene | Cytoband: 4p16.2 | ||
| Entrez ID: 2121 | HGNC ID: HGNC:3497 | Ensembl Gene: ENSG00000072840 | OMIM ID: 604831 |
| Drug and gene relationship at DGIdb | |||
EVC involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04340 | Hedgehog signaling pathway |
Expression of EVC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EVC | 2121 | 219432_at | -0.1630 | 0.8066 | |
| GSE20347 | EVC | 2121 | 210887_s_at | -0.0226 | 0.8239 | |
| GSE23400 | EVC | 2121 | 219432_at | 0.0513 | 0.5845 | |
| GSE26886 | EVC | 2121 | 219432_at | 0.9853 | 0.0001 | |
| GSE29001 | EVC | 2121 | 219432_at | 0.3733 | 0.1419 | |
| GSE38129 | EVC | 2121 | 219432_at | 0.0688 | 0.7546 | |
| GSE45670 | EVC | 2121 | 219432_at | -0.1901 | 0.4353 | |
| GSE53622 | EVC | 2121 | 37388 | 0.2056 | 0.1001 | |
| GSE53624 | EVC | 2121 | 37388 | 0.3763 | 0.0007 | |
| GSE63941 | EVC | 2121 | 219432_at | -2.1388 | 0.0007 | |
| GSE77861 | EVC | 2121 | 210887_s_at | 0.0310 | 0.8689 | |
| GSE97050 | EVC | 2121 | A_24_P60441 | -0.3280 | 0.6326 | |
| SRP007169 | EVC | 2121 | RNAseq | 1.5156 | 0.0177 | |
| SRP008496 | EVC | 2121 | RNAseq | 1.5510 | 0.0037 | |
| SRP064894 | EVC | 2121 | RNAseq | -0.0001 | 0.9999 | |
| SRP133303 | EVC | 2121 | RNAseq | 0.6180 | 0.0349 | |
| SRP159526 | EVC | 2121 | RNAseq | -0.1813 | 0.4380 | |
| SRP193095 | EVC | 2121 | RNAseq | 0.6450 | 0.0009 | |
| SRP219564 | EVC | 2121 | RNAseq | 0.0496 | 0.9263 | |
| TCGA | EVC | 2121 | RNAseq | -0.0585 | 0.5043 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by EVC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EVC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EVC | 2121 | 0 | 18 | 12 | |
| GSE20123 | EVC | 2121 | 0 | 18 | 12 | |
| GSE43470 | EVC | 2121 | 0 | 17 | 26 | |
| GSE46452 | EVC | 2121 | 1 | 36 | 22 | |
| GSE47630 | EVC | 2121 | 1 | 19 | 20 | |
| GSE54993 | EVC | 2121 | 10 | 0 | 60 | |
| GSE54994 | EVC | 2121 | 3 | 12 | 38 | |
| GSE60625 | EVC | 2121 | 0 | 0 | 11 | |
| GSE74703 | EVC | 2121 | 0 | 13 | 23 | |
| GSE74704 | EVC | 2121 | 0 | 10 | 10 | |
| TCGA | EVC | 2121 | 7 | 49 | 40 |
Total number of gains: 22; Total number of losses: 192; Total Number of normals: 274.
Somatic mutations of EVC:
Generating mutation plots.
Highly correlated genes for EVC:
Showing top 20/460 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EVC | TUBG2 | 0.719361 | 4 | 0 | 4 |
| EVC | KCTD19 | 0.679228 | 3 | 0 | 3 |
| EVC | EDNRB | 0.676469 | 4 | 0 | 3 |
| EVC | GDF11 | 0.67308 | 3 | 0 | 3 |
| EVC | CHST15 | 0.668141 | 9 | 0 | 9 |
| EVC | ATF5 | 0.666099 | 5 | 0 | 4 |
| EVC | GNS | 0.665498 | 3 | 0 | 3 |
| EVC | RASSF8 | 0.65481 | 6 | 0 | 6 |
| EVC | ARHGEF6 | 0.650785 | 4 | 0 | 4 |
| EVC | CDH4 | 0.649809 | 3 | 0 | 3 |
| EVC | KLHL26 | 0.647575 | 3 | 0 | 3 |
| EVC | TRPC6 | 0.647533 | 5 | 0 | 4 |
| EVC | MED9 | 0.645977 | 3 | 0 | 3 |
| EVC | CLMP | 0.640223 | 6 | 0 | 5 |
| EVC | FEZ1 | 0.631371 | 7 | 0 | 6 |
| EVC | GNA11 | 0.630889 | 3 | 0 | 3 |
| EVC | ZNF781 | 0.630434 | 4 | 0 | 3 |
| EVC | BAHCC1 | 0.629689 | 6 | 0 | 5 |
| EVC | ZC3H7A | 0.627476 | 5 | 0 | 3 |
| EVC | SYNC | 0.627268 | 4 | 0 | 3 |
For details and further investigation, click here
