C9orf57

 

Full name: chromosome 9 open reading frame 57 Alias Symbol: 
Type: protein-coding gene Cytoband: 9q21.13
Entrez ID: 138240 HGNC ID: HGNC:27037 Ensembl Gene: ENSG00000204669 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of C9orf57:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 C9orf57 138240 240316_at 0.0006 0.9985
GSE26886 C9orf57 138240 240316_at 0.0099 0.9183
GSE45670 C9orf57 138240 240316_at 0.0506 0.5060
GSE53622 C9orf57 138240 49290 0.1051 0.4872
GSE53624 C9orf57 138240 49290 -0.0127 0.8909
GSE63941 C9orf57 138240 240316_at -0.0275 0.8490
GSE77861 C9orf57 138240 240316_at -0.0851 0.2657
TCGA C9orf57 138240 RNAseq 1.0949 0.6205

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by C9orf57 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of C9orf57:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 C9orf57 138240 6 11 13
GSE20123 C9orf57 138240 6 11 13
GSE43470 C9orf57 138240 6 5 32
GSE46452 C9orf57 138240 6 14 39
GSE47630 C9orf57 138240 1 18 21
GSE54993 C9orf57 138240 4 1 65
GSE54994 C9orf57 138240 4 13 36
GSE60625 C9orf57 138240 0 0 11
GSE74703 C9orf57 138240 5 4 27
GSE74704 C9orf57 138240 3 8 9
TCGA C9orf57 138240 19 27 50

Total number of gains: 60; Total number of losses: 112; Total Number of normals: 316.  

 

Somatic mutations of C9orf57:

 

Generating mutation plots.

 

Highly correlated genes for C9orf57:

 

Showing all 8 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
C9orf57POU4F20.631211303
C9orf57C9orf1350.623619303
C9orf57AMER30.59652303
C9orf57SEL1L20.57407303
C9orf57LYZL10.559359303
C9orf57ZNF700.538056403
C9orf57OPN40.525602303
C9orf57KRTAP11-10.525462403

For details and further investigation, click here