| Full name: POU class 4 homeobox 2 | Alias Symbol: Brn-3b | ||
| Type: protein-coding gene | Cytoband: 4q31.22 | ||
| Entrez ID: 5458 | HGNC ID: HGNC:9219 | Ensembl Gene: ENSG00000151615 | OMIM ID: 113725 |
| Drug and gene relationship at DGIdb | |||
Expression of POU4F2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POU4F2 | 5458 | 207725_at | -0.2848 | 0.1011 | |
| GSE20347 | POU4F2 | 5458 | 207725_at | -0.0472 | 0.4476 | |
| GSE23400 | POU4F2 | 5458 | 207725_at | -0.0952 | 0.0122 | |
| GSE26886 | POU4F2 | 5458 | 207725_at | 0.0111 | 0.9323 | |
| GSE29001 | POU4F2 | 5458 | 207725_at | -0.0319 | 0.8582 | |
| GSE38129 | POU4F2 | 5458 | 207725_at | -0.0639 | 0.3439 | |
| GSE45670 | POU4F2 | 5458 | 207725_at | -0.0037 | 0.9644 | |
| GSE53622 | POU4F2 | 5458 | 84417 | 0.0275 | 0.8999 | |
| GSE53624 | POU4F2 | 5458 | 84417 | 0.0012 | 0.9898 | |
| GSE63941 | POU4F2 | 5458 | 207725_at | -0.1484 | 0.3275 | |
| GSE77861 | POU4F2 | 5458 | 207725_at | -0.0580 | 0.5444 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POU4F2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POU4F2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POU4F2 | 5458 | 0 | 12 | 18 | |
| GSE20123 | POU4F2 | 5458 | 0 | 12 | 18 | |
| GSE43470 | POU4F2 | 5458 | 0 | 13 | 30 | |
| GSE46452 | POU4F2 | 5458 | 1 | 36 | 22 | |
| GSE47630 | POU4F2 | 5458 | 0 | 22 | 18 | |
| GSE54993 | POU4F2 | 5458 | 10 | 0 | 60 | |
| GSE54994 | POU4F2 | 5458 | 2 | 11 | 40 | |
| GSE60625 | POU4F2 | 5458 | 0 | 1 | 10 | |
| GSE74703 | POU4F2 | 5458 | 0 | 11 | 25 | |
| GSE74704 | POU4F2 | 5458 | 0 | 7 | 13 | |
| TCGA | POU4F2 | 5458 | 12 | 32 | 52 |
Total number of gains: 25; Total number of losses: 157; Total Number of normals: 306.
Somatic mutations of POU4F2:
Generating mutation plots.
Highly correlated genes for POU4F2:
Showing top 20/334 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POU4F2 | RUNX1T1 | 0.722863 | 3 | 0 | 3 |
| POU4F2 | PTPRJ | 0.711781 | 3 | 0 | 3 |
| POU4F2 | SLC6A5 | 0.706181 | 3 | 0 | 3 |
| POU4F2 | IL17A | 0.701514 | 3 | 0 | 3 |
| POU4F2 | CYP3A43 | 0.670138 | 3 | 0 | 3 |
| POU4F2 | HMGN5 | 0.669789 | 3 | 0 | 3 |
| POU4F2 | MAP1LC3C | 0.665088 | 5 | 0 | 5 |
| POU4F2 | SOAT2 | 0.663205 | 3 | 0 | 3 |
| POU4F2 | OPRL1 | 0.659007 | 5 | 0 | 4 |
| POU4F2 | HTR3B | 0.657604 | 4 | 0 | 4 |
| POU4F2 | KIR2DL2 | 0.654329 | 3 | 0 | 3 |
| POU4F2 | CSN1S1 | 0.653696 | 3 | 0 | 3 |
| POU4F2 | GABRA1 | 0.652505 | 3 | 0 | 3 |
| POU4F2 | NEUROD2 | 0.647582 | 3 | 0 | 3 |
| POU4F2 | SLC5A7 | 0.646156 | 3 | 0 | 3 |
| POU4F2 | AMELY | 0.643343 | 3 | 0 | 3 |
| POU4F2 | PDK4 | 0.641642 | 4 | 0 | 3 |
| POU4F2 | KSR1 | 0.641578 | 3 | 0 | 3 |
| POU4F2 | BRS3 | 0.64088 | 3 | 0 | 3 |
| POU4F2 | CHRNA3 | 0.639636 | 4 | 0 | 4 |
For details and further investigation, click here
