| Full name: cytochrome P450 family 1 subfamily A member 1 | Alias Symbol: P450DX|P1-450|P450-C|CP11 | ||
| Type: protein-coding gene | Cytoband: 15q24.1 | ||
| Entrez ID: 1543 | HGNC ID: HGNC:2595 | Ensembl Gene: ENSG00000140465 | OMIM ID: 108330 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP1A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP1A1 | 1543 | 205749_at | -0.3366 | 0.5966 | |
| GSE20347 | CYP1A1 | 1543 | 205749_at | -0.5544 | 0.0248 | |
| GSE23400 | CYP1A1 | 1543 | 205749_at | -0.2840 | 0.0008 | |
| GSE26886 | CYP1A1 | 1543 | 205749_at | 0.3247 | 0.4922 | |
| GSE29001 | CYP1A1 | 1543 | 205749_at | -0.9990 | 0.0177 | |
| GSE38129 | CYP1A1 | 1543 | 205749_at | -0.6157 | 0.0005 | |
| GSE45670 | CYP1A1 | 1543 | 205749_at | -0.1050 | 0.4199 | |
| GSE53622 | CYP1A1 | 1543 | 6671 | 0.2058 | 0.0520 | |
| GSE53624 | CYP1A1 | 1543 | 6671 | 0.0711 | 0.4436 | |
| GSE63941 | CYP1A1 | 1543 | 205749_at | 1.7285 | 0.2593 | |
| GSE77861 | CYP1A1 | 1543 | 205749_at | -0.0150 | 0.9144 | |
| TCGA | CYP1A1 | 1543 | RNAseq | -1.2003 | 0.1873 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CYP1A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP1A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP1A1 | 1543 | 8 | 1 | 21 | |
| GSE20123 | CYP1A1 | 1543 | 8 | 1 | 21 | |
| GSE43470 | CYP1A1 | 1543 | 4 | 6 | 33 | |
| GSE46452 | CYP1A1 | 1543 | 3 | 7 | 49 | |
| GSE47630 | CYP1A1 | 1543 | 8 | 10 | 22 | |
| GSE54993 | CYP1A1 | 1543 | 5 | 6 | 59 | |
| GSE54994 | CYP1A1 | 1543 | 5 | 7 | 41 | |
| GSE60625 | CYP1A1 | 1543 | 4 | 0 | 7 | |
| GSE74703 | CYP1A1 | 1543 | 4 | 3 | 29 | |
| GSE74704 | CYP1A1 | 1543 | 4 | 1 | 15 | |
| TCGA | CYP1A1 | 1543 | 14 | 15 | 67 |
Total number of gains: 67; Total number of losses: 57; Total Number of normals: 364.
Somatic mutations of CYP1A1:
Generating mutation plots.
Highly correlated genes for CYP1A1:
Showing all 11 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP1A1 | MRO | 0.621113 | 3 | 0 | 3 |
| CYP1A1 | GJC2 | 0.566993 | 5 | 0 | 3 |
| CYP1A1 | SLC7A3 | 0.543812 | 3 | 0 | 3 |
| CYP1A1 | CDRT15 | 0.536146 | 4 | 0 | 3 |
| CYP1A1 | CYP1A2 | 0.528249 | 6 | 0 | 3 |
| CYP1A1 | GABRA2 | 0.527842 | 5 | 0 | 3 |
| CYP1A1 | OSM | 0.522333 | 5 | 0 | 3 |
| CYP1A1 | KRT32 | 0.51573 | 5 | 0 | 4 |
| CYP1A1 | RAB40AL | 0.509131 | 4 | 0 | 3 |
| CYP1A1 | HGFAC | 0.508827 | 4 | 0 | 3 |
| CYP1A1 | CDC14A | 0.504066 | 5 | 0 | 3 |
For details and further investigation, click here
