| Full name: cytochrome P450 family 1 subfamily A member 2 | Alias Symbol: P3-450|CP12 | ||
| Type: protein-coding gene | Cytoband: 15q24.1 | ||
| Entrez ID: 1544 | HGNC ID: HGNC:2596 | Ensembl Gene: ENSG00000140505 | OMIM ID: 124060 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP1A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP1A2 | 1544 | 207608_x_at | -0.0705 | 0.8172 | |
| GSE20347 | CYP1A2 | 1544 | 207608_x_at | 0.1074 | 0.5392 | |
| GSE23400 | CYP1A2 | 1544 | 207608_x_at | -0.1401 | 0.0001 | |
| GSE26886 | CYP1A2 | 1544 | 207608_x_at | 0.1022 | 0.7025 | |
| GSE29001 | CYP1A2 | 1544 | 207608_x_at | -0.2553 | 0.3608 | |
| GSE38129 | CYP1A2 | 1544 | 207608_x_at | -0.1538 | 0.4217 | |
| GSE45670 | CYP1A2 | 1544 | 207609_s_at | 0.0249 | 0.8216 | |
| GSE63941 | CYP1A2 | 1544 | 207608_x_at | 0.5290 | 0.0299 | |
| GSE77861 | CYP1A2 | 1544 | 207608_x_at | -0.0601 | 0.7461 | |
| GSE97050 | CYP1A2 | 1544 | A_33_P3253747 | 0.0213 | 0.9388 | |
| SRP007169 | CYP1A2 | 1544 | RNAseq | 0.8315 | 0.2811 | |
| SRP064894 | CYP1A2 | 1544 | RNAseq | -0.2483 | 0.3591 | |
| SRP133303 | CYP1A2 | 1544 | RNAseq | 0.2226 | 0.0854 | |
| SRP159526 | CYP1A2 | 1544 | RNAseq | -0.1867 | 0.6915 | |
| SRP193095 | CYP1A2 | 1544 | RNAseq | -0.0159 | 0.9118 | |
| SRP219564 | CYP1A2 | 1544 | RNAseq | 0.1868 | 0.7088 | |
| TCGA | CYP1A2 | 1544 | RNAseq | 2.3107 | 0.1601 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CYP1A2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CYP1A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP1A2 | 1544 | 8 | 1 | 21 | |
| GSE20123 | CYP1A2 | 1544 | 8 | 1 | 21 | |
| GSE43470 | CYP1A2 | 1544 | 4 | 6 | 33 | |
| GSE46452 | CYP1A2 | 1544 | 3 | 7 | 49 | |
| GSE47630 | CYP1A2 | 1544 | 8 | 10 | 22 | |
| GSE54993 | CYP1A2 | 1544 | 5 | 6 | 59 | |
| GSE54994 | CYP1A2 | 1544 | 5 | 7 | 41 | |
| GSE60625 | CYP1A2 | 1544 | 4 | 0 | 7 | |
| GSE74703 | CYP1A2 | 1544 | 4 | 3 | 29 | |
| GSE74704 | CYP1A2 | 1544 | 4 | 1 | 15 | |
| TCGA | CYP1A2 | 1544 | 14 | 15 | 67 |
Total number of gains: 67; Total number of losses: 57; Total Number of normals: 364.
Somatic mutations of CYP1A2:
Generating mutation plots.
Highly correlated genes for CYP1A2:
Showing top 20/387 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP1A2 | TAOK1 | 0.807961 | 3 | 0 | 3 |
| CYP1A2 | CWC22 | 0.78866 | 3 | 0 | 3 |
| CYP1A2 | ERN2 | 0.759766 | 3 | 0 | 3 |
| CYP1A2 | TESPA1 | 0.750509 | 3 | 0 | 3 |
| CYP1A2 | OR10H3 | 0.750273 | 4 | 0 | 4 |
| CYP1A2 | LRRC39 | 0.742546 | 3 | 0 | 3 |
| CYP1A2 | ZNF93 | 0.74052 | 3 | 0 | 3 |
| CYP1A2 | STAT2 | 0.738595 | 4 | 0 | 4 |
| CYP1A2 | SPTLC3 | 0.737778 | 4 | 0 | 4 |
| CYP1A2 | STXBP5 | 0.733437 | 3 | 0 | 3 |
| CYP1A2 | C9orf85 | 0.731218 | 3 | 0 | 3 |
| CYP1A2 | SMARCD1 | 0.727695 | 3 | 0 | 3 |
| CYP1A2 | MOCS3 | 0.725051 | 3 | 0 | 3 |
| CYP1A2 | PRKAR2A | 0.723136 | 4 | 0 | 3 |
| CYP1A2 | CCDC84 | 0.717871 | 3 | 0 | 3 |
| CYP1A2 | SPIN4 | 0.716019 | 3 | 0 | 3 |
| CYP1A2 | KHDRBS2 | 0.715367 | 4 | 0 | 4 |
| CYP1A2 | NEU3 | 0.714413 | 5 | 0 | 5 |
| CYP1A2 | PSG9 | 0.710829 | 3 | 0 | 3 |
| CYP1A2 | GML | 0.702407 | 5 | 0 | 5 |
For details and further investigation, click here
