| Full name: gamma-aminobutyric acid type A receptor alpha2 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4p12 | ||
| Entrez ID: 2555 | HGNC ID: HGNC:4076 | Ensembl Gene: ENSG00000151834 | OMIM ID: 137140 |
| Drug and gene relationship at DGIdb | |||
GABRA2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04727 | GABAergic synapse | |
| hsa04742 | Taste transduction | |
| hsa05032 | Morphine addiction |
Expression of GABRA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABRA2 | 2555 | 207014_at | -0.2466 | 0.5125 | |
| GSE20347 | GABRA2 | 2555 | 207014_at | -0.0390 | 0.4207 | |
| GSE23400 | GABRA2 | 2555 | 207014_at | -0.0773 | 0.0003 | |
| GSE26886 | GABRA2 | 2555 | 216039_at | 0.4234 | 0.1371 | |
| GSE29001 | GABRA2 | 2555 | 207014_at | -0.1043 | 0.2654 | |
| GSE38129 | GABRA2 | 2555 | 207014_at | -0.0974 | 0.2057 | |
| GSE45670 | GABRA2 | 2555 | 1554308_s_at | 0.0818 | 0.2630 | |
| GSE63941 | GABRA2 | 2555 | 207014_at | -3.3878 | 0.0013 | |
| GSE77861 | GABRA2 | 2555 | 207014_at | 0.0083 | 0.9327 | |
| GSE97050 | GABRA2 | 2555 | A_23_P167121 | -0.3633 | 0.3811 | |
| SRP133303 | GABRA2 | 2555 | RNAseq | -0.3352 | 0.0967 | |
| SRP193095 | GABRA2 | 2555 | RNAseq | -0.0565 | 0.7227 | |
| TCGA | GABRA2 | 2555 | RNAseq | -1.6330 | 0.0358 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GABRA2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GABRA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABRA2 | 2555 | 1 | 15 | 14 | |
| GSE20123 | GABRA2 | 2555 | 1 | 15 | 14 | |
| GSE43470 | GABRA2 | 2555 | 0 | 14 | 29 | |
| GSE46452 | GABRA2 | 2555 | 1 | 37 | 21 | |
| GSE47630 | GABRA2 | 2555 | 1 | 18 | 21 | |
| GSE54993 | GABRA2 | 2555 | 7 | 0 | 63 | |
| GSE54994 | GABRA2 | 2555 | 4 | 9 | 40 | |
| GSE60625 | GABRA2 | 2555 | 0 | 0 | 11 | |
| GSE74703 | GABRA2 | 2555 | 0 | 12 | 24 | |
| GSE74704 | GABRA2 | 2555 | 0 | 9 | 11 | |
| TCGA | GABRA2 | 2555 | 15 | 34 | 47 |
Total number of gains: 30; Total number of losses: 163; Total Number of normals: 295.
Somatic mutations of GABRA2:
Generating mutation plots.
Highly correlated genes for GABRA2:
Showing top 20/230 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABRA2 | ANO5 | 0.751393 | 3 | 0 | 3 |
| GABRA2 | MPDZ | 0.726646 | 3 | 0 | 3 |
| GABRA2 | PPARGC1A | 0.72191 | 3 | 0 | 3 |
| GABRA2 | WSCD2 | 0.710665 | 3 | 0 | 3 |
| GABRA2 | ATP10A | 0.701798 | 3 | 0 | 3 |
| GABRA2 | LRRN4CL | 0.683799 | 3 | 0 | 3 |
| GABRA2 | SGCG | 0.676262 | 4 | 0 | 4 |
| GABRA2 | DENND2A | 0.671924 | 3 | 0 | 3 |
| GABRA2 | KCNT2 | 0.670874 | 3 | 0 | 3 |
| GABRA2 | BCHE | 0.669289 | 3 | 0 | 3 |
| GABRA2 | ASB5 | 0.668229 | 3 | 0 | 3 |
| GABRA2 | ANGPTL7 | 0.665384 | 4 | 0 | 4 |
| GABRA2 | PARD3B | 0.664603 | 3 | 0 | 3 |
| GABRA2 | TOX | 0.6627 | 3 | 0 | 3 |
| GABRA2 | SAT2 | 0.662489 | 4 | 0 | 4 |
| GABRA2 | NR4A3 | 0.661975 | 4 | 0 | 3 |
| GABRA2 | RAB6B | 0.661197 | 4 | 0 | 3 |
| GABRA2 | SPAG6 | 0.658546 | 3 | 0 | 3 |
| GABRA2 | KIF5A | 0.657689 | 3 | 0 | 3 |
| GABRA2 | PRICKLE2 | 0.655587 | 3 | 0 | 3 |
For details and further investigation, click here
