| Full name: oncostatin M | Alias Symbol: MGC20461 | ||
| Type: protein-coding gene | Cytoband: 22q12.2 | ||
| Entrez ID: 5008 | HGNC ID: HGNC:8506 | Ensembl Gene: ENSG00000099985 | OMIM ID: 165095 |
| Drug and gene relationship at DGIdb | |||
OSM involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway |
Expression of OSM:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OSM | 5008 | 214637_at | -0.1729 | 0.6255 | |
| GSE20347 | OSM | 5008 | 214637_at | -0.0612 | 0.5324 | |
| GSE23400 | OSM | 5008 | 214637_at | -0.1283 | 0.0003 | |
| GSE26886 | OSM | 5008 | 214637_at | -0.1341 | 0.3198 | |
| GSE29001 | OSM | 5008 | 214637_at | -0.0122 | 0.9461 | |
| GSE38129 | OSM | 5008 | 214637_at | -0.1872 | 0.0031 | |
| GSE45670 | OSM | 5008 | 214637_at | 0.0047 | 0.9642 | |
| GSE53622 | OSM | 5008 | 110127 | -0.7876 | 0.0000 | |
| GSE53624 | OSM | 5008 | 110127 | -0.9931 | 0.0000 | |
| GSE63941 | OSM | 5008 | 214637_at | 0.0363 | 0.8220 | |
| GSE77861 | OSM | 5008 | 214637_at | -0.0060 | 0.9740 | |
| GSE97050 | OSM | 5008 | A_23_P166408 | 0.0872 | 0.7778 | |
| SRP007169 | OSM | 5008 | RNAseq | 3.4074 | 0.0020 | |
| SRP064894 | OSM | 5008 | RNAseq | 2.1033 | 0.0000 | |
| SRP133303 | OSM | 5008 | RNAseq | 2.7576 | 0.0000 | |
| SRP159526 | OSM | 5008 | RNAseq | 2.2209 | 0.0008 | |
| SRP193095 | OSM | 5008 | RNAseq | 4.9149 | 0.0000 | |
| SRP219564 | OSM | 5008 | RNAseq | 1.6682 | 0.0521 | |
| TCGA | OSM | 5008 | RNAseq | 1.2216 | 0.0001 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by OSM expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OSM:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OSM | 5008 | 5 | 5 | 20 | |
| GSE20123 | OSM | 5008 | 5 | 4 | 21 | |
| GSE43470 | OSM | 5008 | 4 | 6 | 33 | |
| GSE46452 | OSM | 5008 | 31 | 1 | 27 | |
| GSE47630 | OSM | 5008 | 8 | 5 | 27 | |
| GSE54993 | OSM | 5008 | 3 | 6 | 61 | |
| GSE54994 | OSM | 5008 | 11 | 8 | 34 | |
| GSE60625 | OSM | 5008 | 5 | 0 | 6 | |
| GSE74703 | OSM | 5008 | 4 | 5 | 27 | |
| GSE74704 | OSM | 5008 | 2 | 1 | 17 | |
| TCGA | OSM | 5008 | 27 | 15 | 54 |
Total number of gains: 105; Total number of losses: 56; Total Number of normals: 327.
Somatic mutations of OSM:
Generating mutation plots.
Highly correlated genes for OSM:
Showing top 20/843 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OSM | CABP4 | 0.825949 | 3 | 0 | 3 |
| OSM | TSSK3 | 0.779665 | 3 | 0 | 3 |
| OSM | PVALB | 0.770478 | 3 | 0 | 3 |
| OSM | OR4D2 | 0.764216 | 4 | 0 | 4 |
| OSM | CD247 | 0.757917 | 3 | 0 | 3 |
| OSM | SP7 | 0.725994 | 4 | 0 | 4 |
| OSM | LRTM2 | 0.718756 | 3 | 0 | 3 |
| OSM | CLRN1 | 0.713206 | 3 | 0 | 3 |
| OSM | KRTAP3-1 | 0.712687 | 3 | 0 | 3 |
| OSM | C22orf23 | 0.71015 | 3 | 0 | 3 |
| OSM | C20orf141 | 0.703581 | 3 | 0 | 3 |
| OSM | CCDC157 | 0.699394 | 3 | 0 | 3 |
| OSM | LAT2 | 0.698476 | 3 | 0 | 3 |
| OSM | FHAD1 | 0.694043 | 4 | 0 | 3 |
| OSM | SMOC1 | 0.689044 | 4 | 0 | 3 |
| OSM | SLC4A1 | 0.68871 | 7 | 0 | 6 |
| OSM | GJD4 | 0.685336 | 3 | 0 | 3 |
| OSM | MEGF11 | 0.682166 | 4 | 0 | 4 |
| OSM | GFRA2 | 0.6817 | 6 | 0 | 5 |
| OSM | ASB10 | 0.680003 | 4 | 0 | 4 |
For details and further investigation, click here
