DSG4

 

Full name: desmoglein 4 Alias Symbol: CDHF13|LAH
Type: protein-coding gene Cytoband: 18q12.1
Entrez ID: 147409 HGNC ID: HGNC:21307 Ensembl Gene: ENSG00000175065 OMIM ID: 607892
Drug and gene relationship at DGIdb

 

Expression of DSG4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DSG4 147409 1561330_at 0.0161 0.9655
GSE26886 DSG4 147409 1561330_at 0.1083 0.6577
GSE45670 DSG4 147409 1561330_at 0.1795 0.2466
GSE53622 DSG4 147409 156583 -0.7421 0.0236
GSE53624 DSG4 147409 156583 -1.2562 0.0000
GSE63941 DSG4 147409 1561330_at 0.1202 0.7099
GSE77861 DSG4 147409 1561330_at 0.2199 0.4497
SRP133303 DSG4 147409 RNAseq -2.7245 0.0000
TCGA DSG4 147409 RNAseq 0.5393 0.3713

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by DSG4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DSG4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DSG4 147409 3 6 21
GSE20123 DSG4 147409 3 6 21
GSE43470 DSG4 147409 0 2 41
GSE46452 DSG4 147409 1 25 33
GSE47630 DSG4 147409 5 20 15
GSE54993 DSG4 147409 7 1 62
GSE54994 DSG4 147409 2 16 35
GSE60625 DSG4 147409 0 4 7
GSE74703 DSG4 147409 0 2 34
GSE74704 DSG4 147409 1 5 14
TCGA DSG4 147409 14 36 46

Total number of gains: 36; Total number of losses: 123; Total Number of normals: 329.  

 

Somatic mutations of DSG4:

 

Generating mutation plots.

 

Highly correlated genes for DSG4:

 

Showing all 8 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DSG4GPRC5D0.671208303
DSG4TMPRSS11D0.621543303
DSG4RPTN0.61811303
DSG4FETUB0.601241303
DSG4SPRR1A0.600518303
DSG4SOX210.553303403
DSG4LRRC40.544116503
DSG4LGI30.52172403

For details and further investigation, click here