| Full name: leucine rich repeat LGI family member 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 203190 | HGNC ID: HGNC:18711 | Ensembl Gene: ENSG00000168481 | OMIM ID: 608302 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of LGI3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LGI3 | 203190 | 238061_at | -0.0918 | 0.8634 | |
| GSE26886 | LGI3 | 203190 | 238061_at | -0.3983 | 0.0201 | |
| GSE45670 | LGI3 | 203190 | 238061_at | -0.1613 | 0.3084 | |
| GSE53622 | LGI3 | 203190 | 142534 | -1.5526 | 0.0000 | |
| GSE53624 | LGI3 | 203190 | 142534 | -1.8208 | 0.0000 | |
| GSE63941 | LGI3 | 203190 | 238061_at | 0.1282 | 0.3780 | |
| GSE77861 | LGI3 | 203190 | 238061_at | -0.1247 | 0.7138 | |
| SRP007169 | LGI3 | 203190 | RNAseq | -1.0584 | 0.2833 | |
| SRP008496 | LGI3 | 203190 | RNAseq | -1.6414 | 0.1359 | |
| SRP064894 | LGI3 | 203190 | RNAseq | -2.0906 | 0.0000 | |
| SRP133303 | LGI3 | 203190 | RNAseq | -2.1012 | 0.0010 | |
| SRP159526 | LGI3 | 203190 | RNAseq | -0.5819 | 0.3700 | |
| SRP219564 | LGI3 | 203190 | RNAseq | -3.0987 | 0.0001 | |
| TCGA | LGI3 | 203190 | RNAseq | 0.3272 | 0.4133 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by LGI3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LGI3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LGI3 | 203190 | 4 | 10 | 16 | |
| GSE20123 | LGI3 | 203190 | 4 | 10 | 16 | |
| GSE43470 | LGI3 | 203190 | 4 | 9 | 30 | |
| GSE46452 | LGI3 | 203190 | 13 | 13 | 33 | |
| GSE47630 | LGI3 | 203190 | 10 | 8 | 22 | |
| GSE54993 | LGI3 | 203190 | 2 | 14 | 54 | |
| GSE54994 | LGI3 | 203190 | 8 | 18 | 27 | |
| GSE60625 | LGI3 | 203190 | 3 | 0 | 8 | |
| GSE74703 | LGI3 | 203190 | 4 | 7 | 25 | |
| GSE74704 | LGI3 | 203190 | 3 | 7 | 10 | |
| TCGA | LGI3 | 203190 | 14 | 43 | 39 |
Total number of gains: 69; Total number of losses: 139; Total Number of normals: 280.
Somatic mutations of LGI3:
Generating mutation plots.
Highly correlated genes for LGI3:
Showing top 20/441 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LGI3 | YOD1 | 0.714003 | 3 | 0 | 3 |
| LGI3 | SERPINB12 | 0.69331 | 3 | 0 | 3 |
| LGI3 | IL36A | 0.690978 | 3 | 0 | 3 |
| LGI3 | TOM1L2 | 0.690763 | 3 | 0 | 3 |
| LGI3 | GIPC1 | 0.684743 | 4 | 0 | 4 |
| LGI3 | CLDN17 | 0.678524 | 3 | 0 | 3 |
| LGI3 | FLG | 0.669825 | 3 | 0 | 3 |
| LGI3 | C19orf57 | 0.667818 | 4 | 0 | 3 |
| LGI3 | TOM1 | 0.662691 | 4 | 0 | 4 |
| LGI3 | SMIM5 | 0.659743 | 5 | 0 | 4 |
| LGI3 | SEMA3F | 0.657072 | 5 | 0 | 4 |
| LGI3 | PTK6 | 0.654445 | 4 | 0 | 4 |
| LGI3 | MALL | 0.654127 | 4 | 0 | 4 |
| LGI3 | GPR157 | 0.653733 | 3 | 0 | 3 |
| LGI3 | RASAL1 | 0.653378 | 3 | 0 | 3 |
| LGI3 | SPINK7 | 0.651925 | 5 | 0 | 5 |
| LGI3 | S100A10 | 0.651636 | 3 | 0 | 3 |
| LGI3 | LYNX1 | 0.651217 | 4 | 0 | 4 |
| LGI3 | LPAR5 | 0.650367 | 3 | 0 | 3 |
| LGI3 | TECR | 0.646563 | 4 | 0 | 4 |
For details and further investigation, click here
