| Full name: leucine rich repeat containing 4 | Alias Symbol: NAG14 | ||
| Type: protein-coding gene | Cytoband: 7q32.1 | ||
| Entrez ID: 64101 | HGNC ID: HGNC:15586 | Ensembl Gene: ENSG00000128594 | OMIM ID: 610486 |
| Drug and gene relationship at DGIdb | |||
Expression of LRRC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRC4 | 64101 | 223552_at | -0.0657 | 0.9497 | |
| GSE26886 | LRRC4 | 64101 | 223552_at | 0.3033 | 0.2448 | |
| GSE45670 | LRRC4 | 64101 | 223552_at | 0.5327 | 0.1587 | |
| GSE53622 | LRRC4 | 64101 | 117280 | -0.0346 | 0.8761 | |
| GSE53624 | LRRC4 | 64101 | 117280 | -0.1992 | 0.1938 | |
| GSE63941 | LRRC4 | 64101 | 223552_at | 0.3349 | 0.5340 | |
| GSE77861 | LRRC4 | 64101 | 223552_at | 0.6808 | 0.0785 | |
| GSE97050 | LRRC4 | 64101 | A_33_P3263217 | 0.1810 | 0.3604 | |
| SRP007169 | LRRC4 | 64101 | RNAseq | 2.7312 | 0.0000 | |
| SRP008496 | LRRC4 | 64101 | RNAseq | 2.1352 | 0.0000 | |
| SRP064894 | LRRC4 | 64101 | RNAseq | 0.2959 | 0.6172 | |
| SRP133303 | LRRC4 | 64101 | RNAseq | 1.1978 | 0.0045 | |
| SRP159526 | LRRC4 | 64101 | RNAseq | 1.4293 | 0.0852 | |
| SRP193095 | LRRC4 | 64101 | RNAseq | 1.0560 | 0.0009 | |
| SRP219564 | LRRC4 | 64101 | RNAseq | 0.9059 | 0.2661 | |
| TCGA | LRRC4 | 64101 | RNAseq | 0.2328 | 0.3779 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by LRRC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC4 | 64101 | 7 | 1 | 22 | |
| GSE20123 | LRRC4 | 64101 | 7 | 2 | 21 | |
| GSE43470 | LRRC4 | 64101 | 2 | 3 | 38 | |
| GSE46452 | LRRC4 | 64101 | 7 | 2 | 50 | |
| GSE47630 | LRRC4 | 64101 | 7 | 4 | 29 | |
| GSE54993 | LRRC4 | 64101 | 3 | 5 | 62 | |
| GSE54994 | LRRC4 | 64101 | 9 | 7 | 37 | |
| GSE60625 | LRRC4 | 64101 | 0 | 0 | 11 | |
| GSE74703 | LRRC4 | 64101 | 2 | 3 | 31 | |
| GSE74704 | LRRC4 | 64101 | 3 | 2 | 15 | |
| TCGA | LRRC4 | 64101 | 28 | 22 | 46 |
Total number of gains: 75; Total number of losses: 51; Total Number of normals: 362.
Somatic mutations of LRRC4:
Generating mutation plots.
Highly correlated genes for LRRC4:
Showing top 20/50 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC4 | ATXN7L2 | 0.734194 | 3 | 0 | 3 |
| LRRC4 | APOM | 0.730907 | 4 | 0 | 4 |
| LRRC4 | RANBP3 | 0.728287 | 3 | 0 | 3 |
| LRRC4 | B9D1 | 0.716559 | 3 | 0 | 3 |
| LRRC4 | ARMC7 | 0.713732 | 3 | 0 | 3 |
| LRRC4 | KRT77 | 0.711821 | 3 | 0 | 3 |
| LRRC4 | C19orf25 | 0.702956 | 3 | 0 | 3 |
| LRRC4 | PNPLA2 | 0.68061 | 3 | 0 | 3 |
| LRRC4 | CHP2 | 0.676277 | 4 | 0 | 3 |
| LRRC4 | KLRG2 | 0.675549 | 4 | 0 | 3 |
| LRRC4 | SOST | 0.673601 | 3 | 0 | 3 |
| LRRC4 | SCN9A | 0.666991 | 5 | 0 | 4 |
| LRRC4 | SLC27A5 | 0.654211 | 3 | 0 | 3 |
| LRRC4 | GPRC5D | 0.648414 | 7 | 0 | 6 |
| LRRC4 | CECR2 | 0.641027 | 4 | 0 | 3 |
| LRRC4 | ASRGL1 | 0.635277 | 4 | 0 | 3 |
| LRRC4 | PPIP5K1 | 0.631046 | 3 | 0 | 3 |
| LRRC4 | NTS | 0.630524 | 5 | 0 | 4 |
| LRRC4 | FASTK | 0.619129 | 4 | 0 | 3 |
| LRRC4 | JAKMIP3 | 0.613244 | 4 | 0 | 3 |
For details and further investigation, click here
