GPRC5D

 

Full name: G protein-coupled receptor class C group 5 member D Alias Symbol: 
Type: protein-coding gene Cytoband: 12p13.1
Entrez ID: 55507 HGNC ID: HGNC:13310 Ensembl Gene: ENSG00000111291 OMIM ID: 607437
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of GPRC5D:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GPRC5D 55507 221297_at -0.0580 0.9319
GSE20347 GPRC5D 55507 221297_at -0.0440 0.6815
GSE23400 GPRC5D 55507 221297_at -0.1617 0.0053
GSE26886 GPRC5D 55507 221297_at -0.1939 0.5851
GSE29001 GPRC5D 55507 221297_at -0.3438 0.0770
GSE38129 GPRC5D 55507 221297_at 0.1200 0.6213
GSE45670 GPRC5D 55507 221297_at 0.2061 0.3687
GSE53622 GPRC5D 55507 60932 0.2149 0.2471
GSE53624 GPRC5D 55507 60932 -0.3101 0.0108
GSE63941 GPRC5D 55507 221297_at 0.1365 0.3917
GSE77861 GPRC5D 55507 221297_at 0.3155 0.4845
GSE97050 GPRC5D 55507 A_23_P105691 0.0788 0.8057
SRP007169 GPRC5D 55507 RNAseq 0.8475 0.2427
SRP064894 GPRC5D 55507 RNAseq -0.6131 0.1109
SRP133303 GPRC5D 55507 RNAseq 0.0755 0.8361
SRP159526 GPRC5D 55507 RNAseq 2.3853 0.0074
TCGA GPRC5D 55507 RNAseq 0.4334 0.1966

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by GPRC5D expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GPRC5D:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GPRC5D 55507 6 2 22
GSE20123 GPRC5D 55507 6 2 22
GSE43470 GPRC5D 55507 10 4 29
GSE46452 GPRC5D 55507 10 1 48
GSE47630 GPRC5D 55507 13 2 25
GSE54993 GPRC5D 55507 2 9 59
GSE54994 GPRC5D 55507 10 2 41
GSE60625 GPRC5D 55507 0 1 10
GSE74703 GPRC5D 55507 9 3 24
GSE74704 GPRC5D 55507 4 1 15
TCGA GPRC5D 55507 39 7 50

Total number of gains: 109; Total number of losses: 34; Total Number of normals: 345.  

 

Somatic mutations of GPRC5D:

 

Generating mutation plots.

 

Highly correlated genes for GPRC5D:

 

Showing top 20/273 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GPRC5DPRG30.725372303
GPRC5DDRD30.69783303
GPRC5DPOU1F10.682104303
GPRC5DGH10.677365303
GPRC5DDSG40.671208303
GPRC5DTTC39A0.668646303
GPRC5DRHBG0.666867404
GPRC5DOR2C10.666461403
GPRC5DGABRD0.666306403
GPRC5DGFRA40.660023404
GPRC5DMAGEL20.65901303
GPRC5DLRRC40.648414706
GPRC5DFETUB0.648236606
GPRC5DDENND1C0.647258303
GPRC5DHPR0.646705403
GPRC5DSHOX0.644464303
GPRC5DMAT1A0.644281504
GPRC5DDAO0.643543403
GPRC5DAICDA0.642603504
GPRC5DHRC0.637205404

For details and further investigation, click here