| Full name: SRY-box transcription factor 21 | Alias Symbol: SOX25 | ||
| Type: protein-coding gene | Cytoband: 13q32.1 | ||
| Entrez ID: 11166 | HGNC ID: HGNC:11197 | Ensembl Gene: ENSG00000125285 | OMIM ID: 604974 |
| Drug and gene relationship at DGIdb | |||
Expression of SOX21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOX21 | 11166 | 208468_at | -0.0595 | 0.8807 | |
| GSE20347 | SOX21 | 11166 | 208468_at | 0.0235 | 0.8075 | |
| GSE23400 | SOX21 | 11166 | 208468_at | -0.1178 | 0.0099 | |
| GSE26886 | SOX21 | 11166 | 208468_at | 0.0881 | 0.5843 | |
| GSE29001 | SOX21 | 11166 | 208468_at | -0.1757 | 0.2219 | |
| GSE38129 | SOX21 | 11166 | 208468_at | -0.0506 | 0.6202 | |
| GSE45670 | SOX21 | 11166 | 208468_at | 0.1379 | 0.2313 | |
| GSE53622 | SOX21 | 11166 | 112457 | -0.2250 | 0.2749 | |
| GSE53624 | SOX21 | 11166 | 112457 | -0.1946 | 0.1460 | |
| GSE63941 | SOX21 | 11166 | 208468_at | 0.8695 | 0.0937 | |
| GSE77861 | SOX21 | 11166 | 208468_at | -0.0254 | 0.8791 | |
| GSE97050 | SOX21 | 11166 | A_24_P407259 | -0.2096 | 0.6773 | |
| SRP007169 | SOX21 | 11166 | RNAseq | -0.9099 | 0.0332 | |
| SRP008496 | SOX21 | 11166 | RNAseq | -1.4142 | 0.0000 | |
| SRP064894 | SOX21 | 11166 | RNAseq | -0.8335 | 0.1687 | |
| SRP133303 | SOX21 | 11166 | RNAseq | -0.4848 | 0.5305 | |
| SRP159526 | SOX21 | 11166 | RNAseq | -0.5907 | 0.3286 | |
| SRP193095 | SOX21 | 11166 | RNAseq | -2.0319 | 0.0000 | |
| SRP219564 | SOX21 | 11166 | RNAseq | -1.8597 | 0.1203 | |
| TCGA | SOX21 | 11166 | RNAseq | -0.6219 | 0.1184 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SOX21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOX21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOX21 | 11166 | 4 | 9 | 17 | |
| GSE20123 | SOX21 | 11166 | 4 | 8 | 18 | |
| GSE43470 | SOX21 | 11166 | 2 | 12 | 29 | |
| GSE46452 | SOX21 | 11166 | 0 | 32 | 27 | |
| GSE47630 | SOX21 | 11166 | 3 | 27 | 10 | |
| GSE54993 | SOX21 | 11166 | 11 | 3 | 56 | |
| GSE54994 | SOX21 | 11166 | 3 | 14 | 36 | |
| GSE60625 | SOX21 | 11166 | 0 | 3 | 8 | |
| GSE74703 | SOX21 | 11166 | 2 | 10 | 24 | |
| GSE74704 | SOX21 | 11166 | 2 | 8 | 10 | |
| TCGA | SOX21 | 11166 | 13 | 33 | 50 |
Total number of gains: 44; Total number of losses: 159; Total Number of normals: 285.
Somatic mutations of SOX21:
Generating mutation plots.
Highly correlated genes for SOX21:
Showing top 20/278 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOX21 | MAL2 | 0.675887 | 3 | 0 | 3 |
| SOX21 | LIPH | 0.67229 | 3 | 0 | 3 |
| SOX21 | SMAGP | 0.658228 | 3 | 0 | 3 |
| SOX21 | MACC1 | 0.637637 | 3 | 0 | 3 |
| SOX21 | GRHL3 | 0.627717 | 4 | 0 | 3 |
| SOX21 | DSC2 | 0.626738 | 3 | 0 | 3 |
| SOX21 | ZSCAN10 | 0.622717 | 3 | 0 | 3 |
| SOX21 | RPS6KA6 | 0.61869 | 4 | 0 | 3 |
| SOX21 | CYP2F1 | 0.617389 | 3 | 0 | 3 |
| SOX21 | CCDC70 | 0.616159 | 6 | 0 | 5 |
| SOX21 | HPX | 0.614546 | 6 | 0 | 5 |
| SOX21 | DSCAM | 0.614464 | 6 | 0 | 6 |
| SOX21 | KLHL30-AS1 | 0.607933 | 4 | 0 | 4 |
| SOX21 | PPFIA2 | 0.605968 | 4 | 0 | 4 |
| SOX21 | ABCA13 | 0.605938 | 4 | 0 | 3 |
| SOX21 | NRAP | 0.605859 | 5 | 0 | 4 |
| SOX21 | GABRQ | 0.605171 | 5 | 0 | 5 |
| SOX21 | MC2R | 0.604805 | 5 | 0 | 4 |
| SOX21 | TMEM238 | 0.60192 | 4 | 0 | 3 |
| SOX21 | FDXR | 0.601045 | 3 | 0 | 3 |
For details and further investigation, click here
