| Full name: small proline rich protein 1A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 6698 | HGNC ID: HGNC:11259 | Ensembl Gene: ENSG00000169474 | OMIM ID: 182265 |
| Drug and gene relationship at DGIdb | |||
Expression of SPRR1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPRR1A | 6698 | 213796_at | -1.3290 | 0.5150 | |
| GSE20347 | SPRR1A | 6698 | 213796_at | -2.2295 | 0.0048 | |
| GSE23400 | SPRR1A | 6698 | 213796_at | -1.6142 | 0.0000 | |
| GSE26886 | SPRR1A | 6698 | 213796_at | -5.0761 | 0.0000 | |
| GSE29001 | SPRR1A | 6698 | 213796_at | -2.1682 | 0.0563 | |
| GSE38129 | SPRR1A | 6698 | 213796_at | -1.1085 | 0.2159 | |
| GSE45670 | SPRR1A | 6698 | 213796_at | -0.0892 | 0.5477 | |
| GSE53622 | SPRR1A | 6698 | 93626 | -1.3080 | 0.0000 | |
| GSE53624 | SPRR1A | 6698 | 93626 | -1.7196 | 0.0000 | |
| GSE63941 | SPRR1A | 6698 | 214549_x_at | 0.9413 | 0.3164 | |
| GSE77861 | SPRR1A | 6698 | 213796_at | -0.4028 | 0.1340 | |
| GSE97050 | SPRR1A | 6698 | A_23_P348208 | -0.3014 | 0.4239 | |
| SRP007169 | SPRR1A | 6698 | RNAseq | -4.1547 | 0.0000 | |
| SRP008496 | SPRR1A | 6698 | RNAseq | -3.8829 | 0.0000 | |
| SRP064894 | SPRR1A | 6698 | RNAseq | -3.3038 | 0.0000 | |
| SRP133303 | SPRR1A | 6698 | RNAseq | -2.6636 | 0.0000 | |
| SRP159526 | SPRR1A | 6698 | RNAseq | -3.5958 | 0.0003 | |
| SRP219564 | SPRR1A | 6698 | RNAseq | -3.5414 | 0.0095 | |
| TCGA | SPRR1A | 6698 | RNAseq | 0.8073 | 0.0274 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by SPRR1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPRR1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPRR1A | 6698 | 15 | 0 | 15 | |
| GSE20123 | SPRR1A | 6698 | 15 | 0 | 15 | |
| GSE43470 | SPRR1A | 6698 | 6 | 2 | 35 | |
| GSE46452 | SPRR1A | 6698 | 3 | 1 | 55 | |
| GSE47630 | SPRR1A | 6698 | 15 | 0 | 25 | |
| GSE54993 | SPRR1A | 6698 | 0 | 4 | 66 | |
| GSE54994 | SPRR1A | 6698 | 15 | 0 | 38 | |
| GSE60625 | SPRR1A | 6698 | 0 | 0 | 11 | |
| GSE74703 | SPRR1A | 6698 | 6 | 1 | 29 | |
| GSE74704 | SPRR1A | 6698 | 7 | 0 | 13 | |
| TCGA | SPRR1A | 6698 | 39 | 2 | 55 |
Total number of gains: 121; Total number of losses: 10; Total Number of normals: 357.
Somatic mutations of SPRR1A:
Generating mutation plots.
Highly correlated genes for SPRR1A:
Showing top 20/965 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPRR1A | SPRR2A | 0.891215 | 4 | 0 | 4 |
| SPRR1A | SPRR2F | 0.882916 | 4 | 0 | 4 |
| SPRR1A | SPRR2E | 0.865742 | 4 | 0 | 4 |
| SPRR1A | SPRR2D | 0.857478 | 4 | 0 | 4 |
| SPRR1A | SPRR1B | 0.843332 | 13 | 0 | 12 |
| SPRR1A | SPRR3 | 0.834346 | 13 | 0 | 13 |
| SPRR1A | CNFN | 0.8204 | 8 | 0 | 8 |
| SPRR1A | CSTA | 0.815085 | 10 | 0 | 10 |
| SPRR1A | CYSRT1 | 0.806538 | 6 | 0 | 6 |
| SPRR1A | TGM1 | 0.803804 | 12 | 0 | 12 |
| SPRR1A | SERPINB13 | 0.802011 | 12 | 0 | 12 |
| SPRR1A | PGLYRP3 | 0.787169 | 4 | 0 | 4 |
| SPRR1A | SBSN | 0.78155 | 8 | 0 | 8 |
| SPRR1A | CSTB | 0.780811 | 12 | 0 | 12 |
| SPRR1A | LYNX1 | 0.780575 | 8 | 0 | 7 |
| SPRR1A | TMPRSS11D | 0.777926 | 13 | 0 | 13 |
| SPRR1A | MALL | 0.774058 | 12 | 0 | 12 |
| SPRR1A | ANXA1 | 0.773601 | 12 | 0 | 12 |
| SPRR1A | SCEL | 0.772974 | 12 | 0 | 12 |
| SPRR1A | IL1RN | 0.771697 | 13 | 0 | 12 |
For details and further investigation, click here
