| Full name: G protein subunit alpha z | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q11.22-q11.23 | ||
| Entrez ID: 2781 | HGNC ID: HGNC:4395 | Ensembl Gene: ENSG00000128266 | OMIM ID: 139160 |
| Drug and gene relationship at DGIdb | |||
GNAZ involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04730 | Long-term depression |
Expression of GNAZ:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GNAZ | 2781 | 204993_at | -0.5139 | 0.4574 | |
| GSE20347 | GNAZ | 2781 | 204993_at | 0.1288 | 0.3901 | |
| GSE23400 | GNAZ | 2781 | 204993_at | -0.2584 | 0.0003 | |
| GSE26886 | GNAZ | 2781 | 204993_at | 0.8633 | 0.0001 | |
| GSE29001 | GNAZ | 2781 | 204993_at | 0.1957 | 0.5888 | |
| GSE38129 | GNAZ | 2781 | 204993_at | -0.2887 | 0.2468 | |
| GSE45670 | GNAZ | 2781 | 204993_at | -0.4569 | 0.0161 | |
| GSE53622 | GNAZ | 2781 | 88374 | -0.4314 | 0.0013 | |
| GSE53624 | GNAZ | 2781 | 88374 | -0.6351 | 0.0000 | |
| GSE63941 | GNAZ | 2781 | 204993_at | -0.1293 | 0.7840 | |
| GSE77861 | GNAZ | 2781 | 204993_at | 0.0579 | 0.4985 | |
| GSE97050 | GNAZ | 2781 | A_23_P416581 | -0.6379 | 0.2451 | |
| SRP064894 | GNAZ | 2781 | RNAseq | -0.4607 | 0.2812 | |
| SRP133303 | GNAZ | 2781 | RNAseq | -0.3361 | 0.4771 | |
| SRP159526 | GNAZ | 2781 | RNAseq | 0.4909 | 0.2511 | |
| SRP219564 | GNAZ | 2781 | RNAseq | -0.3729 | 0.7165 | |
| TCGA | GNAZ | 2781 | RNAseq | -1.0445 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GNAZ expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GNAZ:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GNAZ | 2781 | 5 | 7 | 18 | |
| GSE20123 | GNAZ | 2781 | 5 | 6 | 19 | |
| GSE43470 | GNAZ | 2781 | 3 | 6 | 34 | |
| GSE46452 | GNAZ | 2781 | 32 | 1 | 26 | |
| GSE47630 | GNAZ | 2781 | 8 | 5 | 27 | |
| GSE54993 | GNAZ | 2781 | 3 | 6 | 61 | |
| GSE54994 | GNAZ | 2781 | 11 | 7 | 35 | |
| GSE60625 | GNAZ | 2781 | 5 | 0 | 6 | |
| GSE74703 | GNAZ | 2781 | 3 | 5 | 28 | |
| GSE74704 | GNAZ | 2781 | 2 | 3 | 15 | |
| TCGA | GNAZ | 2781 | 27 | 16 | 53 |
Total number of gains: 104; Total number of losses: 62; Total Number of normals: 322.
Somatic mutations of GNAZ:
Generating mutation plots.
Highly correlated genes for GNAZ:
Showing top 20/419 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GNAZ | TXLNB | 0.770703 | 3 | 0 | 3 |
| GNAZ | HRCT1 | 0.752014 | 3 | 0 | 3 |
| GNAZ | TOX2 | 0.745586 | 3 | 0 | 3 |
| GNAZ | BCL2L13 | 0.745582 | 3 | 0 | 3 |
| GNAZ | U2AF1L4 | 0.743447 | 3 | 0 | 3 |
| GNAZ | ITGB1BP2 | 0.73077 | 7 | 0 | 7 |
| GNAZ | ZNF483 | 0.722835 | 3 | 0 | 3 |
| GNAZ | CHP2 | 0.718684 | 4 | 0 | 4 |
| GNAZ | FAM184A | 0.715903 | 9 | 0 | 9 |
| GNAZ | ZNF781 | 0.714361 | 3 | 0 | 3 |
| GNAZ | NR2F1-AS1 | 0.712163 | 4 | 0 | 4 |
| GNAZ | USP51 | 0.711447 | 3 | 0 | 3 |
| GNAZ | JAZF1 | 0.705733 | 3 | 0 | 3 |
| GNAZ | SLC35F1 | 0.701141 | 3 | 0 | 3 |
| GNAZ | GKAP1 | 0.698442 | 6 | 0 | 5 |
| GNAZ | ANKDD1A | 0.69785 | 4 | 0 | 4 |
| GNAZ | NNT-AS1 | 0.692562 | 3 | 0 | 3 |
| GNAZ | PHF10 | 0.691897 | 3 | 0 | 3 |
| GNAZ | MTURN | 0.687555 | 4 | 0 | 3 |
| GNAZ | SLC35G1 | 0.682613 | 4 | 0 | 4 |
For details and further investigation, click here
