| Full name: TOX high mobility group box family member 2 | Alias Symbol: dJ1108D11.2|GCX-1 | ||
| Type: protein-coding gene | Cytoband: 20q13.12 | ||
| Entrez ID: 84969 | HGNC ID: HGNC:16095 | Ensembl Gene: ENSG00000124191 | OMIM ID: 611163 |
| Drug and gene relationship at DGIdb | |||
Expression of TOX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TOX2 | 84969 | 228737_at | -0.2591 | 0.8331 | |
| GSE26886 | TOX2 | 84969 | 228737_at | 2.5652 | 0.0000 | |
| GSE45670 | TOX2 | 84969 | 228737_at | -0.6215 | 0.2286 | |
| GSE53622 | TOX2 | 84969 | 36543 | 0.3376 | 0.0001 | |
| GSE53624 | TOX2 | 84969 | 36543 | 0.4458 | 0.0000 | |
| GSE63941 | TOX2 | 84969 | 228737_at | -0.0908 | 0.9381 | |
| GSE77861 | TOX2 | 84969 | 228737_at | 0.9029 | 0.0542 | |
| GSE97050 | TOX2 | 84969 | A_23_P154566 | -0.2410 | 0.5332 | |
| SRP064894 | TOX2 | 84969 | RNAseq | -0.4315 | 0.2222 | |
| SRP133303 | TOX2 | 84969 | RNAseq | 0.6971 | 0.0078 | |
| SRP159526 | TOX2 | 84969 | RNAseq | -0.3907 | 0.3461 | |
| SRP193095 | TOX2 | 84969 | RNAseq | 1.5881 | 0.0000 | |
| SRP219564 | TOX2 | 84969 | RNAseq | 0.2492 | 0.6597 | |
| TCGA | TOX2 | 84969 | RNAseq | -0.0349 | 0.8293 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TOX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TOX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TOX2 | 84969 | 13 | 2 | 15 | |
| GSE20123 | TOX2 | 84969 | 13 | 2 | 15 | |
| GSE43470 | TOX2 | 84969 | 12 | 1 | 30 | |
| GSE46452 | TOX2 | 84969 | 29 | 0 | 30 | |
| GSE47630 | TOX2 | 84969 | 24 | 0 | 16 | |
| GSE54993 | TOX2 | 84969 | 0 | 17 | 53 | |
| GSE54994 | TOX2 | 84969 | 25 | 0 | 28 | |
| GSE60625 | TOX2 | 84969 | 0 | 0 | 11 | |
| GSE74703 | TOX2 | 84969 | 10 | 1 | 25 | |
| GSE74704 | TOX2 | 84969 | 9 | 0 | 11 | |
| TCGA | TOX2 | 84969 | 46 | 2 | 48 |
Total number of gains: 181; Total number of losses: 25; Total Number of normals: 282.
Somatic mutations of TOX2:
Generating mutation plots.
Highly correlated genes for TOX2:
Showing top 20/127 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TOX2 | GTF2IRD2 | 0.787627 | 3 | 0 | 3 |
| TOX2 | KRTAP4-1 | 0.769595 | 3 | 0 | 3 |
| TOX2 | POLD1 | 0.749549 | 3 | 0 | 3 |
| TOX2 | GNAZ | 0.745586 | 3 | 0 | 3 |
| TOX2 | MAMLD1 | 0.739486 | 4 | 0 | 3 |
| TOX2 | SOX12 | 0.733813 | 3 | 0 | 3 |
| TOX2 | TNFAIP8L1 | 0.723463 | 4 | 0 | 3 |
| TOX2 | MLF1 | 0.722513 | 3 | 0 | 3 |
| TOX2 | DNMT3B | 0.721324 | 4 | 0 | 3 |
| TOX2 | RAD51D | 0.718942 | 3 | 0 | 3 |
| TOX2 | PHF21A | 0.717601 | 3 | 0 | 3 |
| TOX2 | BAHCC1 | 0.712766 | 3 | 0 | 3 |
| TOX2 | SDC2 | 0.701988 | 3 | 0 | 3 |
| TOX2 | NOC4L | 0.698609 | 3 | 0 | 3 |
| TOX2 | FAM189B | 0.697727 | 3 | 0 | 3 |
| TOX2 | BEST2 | 0.695239 | 3 | 0 | 3 |
| TOX2 | TREM1 | 0.693923 | 3 | 0 | 3 |
| TOX2 | FBLN7 | 0.692517 | 3 | 0 | 3 |
| TOX2 | PCDH10 | 0.69234 | 3 | 0 | 3 |
| TOX2 | SCN1B | 0.686809 | 4 | 0 | 4 |
For details and further investigation, click here
