| Full name: integrin subunit alpha 2b | Alias Symbol: CD41B|CD41|PPP1R93 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 3674 | HGNC ID: HGNC:6138 | Ensembl Gene: ENSG00000005961 | OMIM ID: 607759 |
| Drug and gene relationship at DGIdb | |||
ITGA2B involved pathways:
Expression of ITGA2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITGA2B | 3674 | 206493_at | 0.1199 | 0.6672 | |
| GSE20347 | ITGA2B | 3674 | 206493_at | 0.1218 | 0.1992 | |
| GSE23400 | ITGA2B | 3674 | 206493_at | 0.0530 | 0.2564 | |
| GSE26886 | ITGA2B | 3674 | 206493_at | 0.3219 | 0.0255 | |
| GSE29001 | ITGA2B | 3674 | 206493_at | 0.3145 | 0.3102 | |
| GSE38129 | ITGA2B | 3674 | 206493_at | 0.0094 | 0.9422 | |
| GSE45670 | ITGA2B | 3674 | 206493_at | 0.0926 | 0.4037 | |
| GSE53622 | ITGA2B | 3674 | 18969 | 0.3325 | 0.0007 | |
| GSE53624 | ITGA2B | 3674 | 18969 | 0.1174 | 0.2201 | |
| GSE63941 | ITGA2B | 3674 | 206493_at | 0.3618 | 0.0613 | |
| GSE77861 | ITGA2B | 3674 | 206493_at | -0.0757 | 0.6758 | |
| GSE97050 | ITGA2B | 3674 | A_24_P65373 | 0.2667 | 0.2581 | |
| SRP064894 | ITGA2B | 3674 | RNAseq | 1.6335 | 0.0000 | |
| SRP133303 | ITGA2B | 3674 | RNAseq | 0.1042 | 0.7692 | |
| SRP219564 | ITGA2B | 3674 | RNAseq | 1.9294 | 0.0040 | |
| TCGA | ITGA2B | 3674 | RNAseq | 1.7507 | 0.0001 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by ITGA2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITGA2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITGA2B | 3674 | 5 | 2 | 23 | |
| GSE20123 | ITGA2B | 3674 | 5 | 2 | 23 | |
| GSE43470 | ITGA2B | 3674 | 1 | 2 | 40 | |
| GSE46452 | ITGA2B | 3674 | 32 | 0 | 27 | |
| GSE47630 | ITGA2B | 3674 | 9 | 0 | 31 | |
| GSE54993 | ITGA2B | 3674 | 3 | 4 | 63 | |
| GSE54994 | ITGA2B | 3674 | 8 | 5 | 40 | |
| GSE60625 | ITGA2B | 3674 | 4 | 0 | 7 | |
| GSE74703 | ITGA2B | 3674 | 1 | 1 | 34 | |
| GSE74704 | ITGA2B | 3674 | 3 | 1 | 16 | |
| TCGA | ITGA2B | 3674 | 24 | 7 | 65 |
Total number of gains: 95; Total number of losses: 24; Total Number of normals: 369.
Somatic mutations of ITGA2B:
Generating mutation plots.
Highly correlated genes for ITGA2B:
Showing top 20/401 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITGA2B | WDR83 | 0.890847 | 3 | 0 | 3 |
| ITGA2B | C7orf61 | 0.833367 | 3 | 0 | 3 |
| ITGA2B | ZNF182 | 0.82039 | 3 | 0 | 3 |
| ITGA2B | C19orf25 | 0.792563 | 3 | 0 | 3 |
| ITGA2B | ING5 | 0.780695 | 3 | 0 | 3 |
| ITGA2B | SLC22A16 | 0.776735 | 3 | 0 | 3 |
| ITGA2B | CHD5 | 0.769753 | 4 | 0 | 4 |
| ITGA2B | GAS6-AS1 | 0.768121 | 3 | 0 | 3 |
| ITGA2B | OR1J4 | 0.7677 | 3 | 0 | 3 |
| ITGA2B | SLC22A31 | 0.76538 | 3 | 0 | 3 |
| ITGA2B | FAM24B | 0.764431 | 3 | 0 | 3 |
| ITGA2B | HRK | 0.760985 | 3 | 0 | 3 |
| ITGA2B | ATP7B | 0.759951 | 3 | 0 | 3 |
| ITGA2B | BTBD19 | 0.75799 | 3 | 0 | 3 |
| ITGA2B | BSND | 0.757323 | 3 | 0 | 3 |
| ITGA2B | ZNF329 | 0.755003 | 3 | 0 | 3 |
| ITGA2B | KCP | 0.74935 | 3 | 0 | 3 |
| ITGA2B | RTN4RL1 | 0.743682 | 3 | 0 | 3 |
| ITGA2B | NKAIN4 | 0.741074 | 3 | 0 | 3 |
| ITGA2B | TSPAN10 | 0.740809 | 3 | 0 | 3 |
For details and further investigation, click here
