| Full name: ATPase copper transporting beta | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q14.3 | ||
| Entrez ID: 540 | HGNC ID: HGNC:870 | Ensembl Gene: ENSG00000123191 | OMIM ID: 606882 |
| Drug and gene relationship at DGIdb | |||
Expression of ATP7B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATP7B | 540 | 204624_at | 0.6212 | 0.2608 | |
| GSE20347 | ATP7B | 540 | 204624_at | -0.0620 | 0.3733 | |
| GSE23400 | ATP7B | 540 | 204624_at | -0.1170 | 0.0024 | |
| GSE26886 | ATP7B | 540 | 204624_at | 0.0846 | 0.7564 | |
| GSE29001 | ATP7B | 540 | 204624_at | -0.0290 | 0.9237 | |
| GSE38129 | ATP7B | 540 | 204624_at | -0.2001 | 0.0400 | |
| GSE45670 | ATP7B | 540 | 204624_at | -0.1520 | 0.4488 | |
| GSE53622 | ATP7B | 540 | 146262 | -0.1911 | 0.1093 | |
| GSE53624 | ATP7B | 540 | 146262 | -0.6759 | 0.0000 | |
| GSE63941 | ATP7B | 540 | 204624_at | -0.3874 | 0.5982 | |
| GSE77861 | ATP7B | 540 | 204624_at | 0.0032 | 0.9867 | |
| GSE97050 | ATP7B | 540 | A_23_P205228 | -0.1057 | 0.7217 | |
| SRP007169 | ATP7B | 540 | RNAseq | 1.5612 | 0.0910 | |
| SRP064894 | ATP7B | 540 | RNAseq | 0.1685 | 0.4728 | |
| SRP133303 | ATP7B | 540 | RNAseq | 0.0482 | 0.9130 | |
| SRP159526 | ATP7B | 540 | RNAseq | -0.2865 | 0.2678 | |
| SRP193095 | ATP7B | 540 | RNAseq | -1.2524 | 0.0060 | |
| SRP219564 | ATP7B | 540 | RNAseq | -0.2560 | 0.6366 | |
| TCGA | ATP7B | 540 | RNAseq | -0.8169 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ATP7B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATP7B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATP7B | 540 | 1 | 13 | 16 | |
| GSE20123 | ATP7B | 540 | 1 | 12 | 17 | |
| GSE43470 | ATP7B | 540 | 3 | 12 | 28 | |
| GSE46452 | ATP7B | 540 | 0 | 32 | 27 | |
| GSE47630 | ATP7B | 540 | 2 | 27 | 11 | |
| GSE54993 | ATP7B | 540 | 12 | 2 | 56 | |
| GSE54994 | ATP7B | 540 | 1 | 15 | 37 | |
| GSE60625 | ATP7B | 540 | 0 | 3 | 8 | |
| GSE74703 | ATP7B | 540 | 3 | 10 | 23 | |
| GSE74704 | ATP7B | 540 | 0 | 9 | 11 | |
| TCGA | ATP7B | 540 | 10 | 35 | 51 |
Total number of gains: 33; Total number of losses: 170; Total Number of normals: 285.
Somatic mutations of ATP7B:
Generating mutation plots.
Highly correlated genes for ATP7B:
Showing top 20/66 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATP7B | ITGA2B | 0.759951 | 3 | 0 | 3 |
| ATP7B | CRABP1 | 0.731123 | 4 | 0 | 4 |
| ATP7B | TNNC2 | 0.711811 | 3 | 0 | 3 |
| ATP7B | TIMM22 | 0.711136 | 3 | 0 | 3 |
| ATP7B | ANKRD33B | 0.710667 | 3 | 0 | 3 |
| ATP7B | CLEC12B | 0.702622 | 3 | 0 | 3 |
| ATP7B | SLC22A16 | 0.693869 | 4 | 0 | 3 |
| ATP7B | MYBPC1 | 0.686988 | 4 | 0 | 3 |
| ATP7B | NRXN1 | 0.678203 | 5 | 0 | 5 |
| ATP7B | POMT2 | 0.667986 | 4 | 0 | 3 |
| ATP7B | SUDS3 | 0.666054 | 3 | 0 | 3 |
| ATP7B | TRAM1L1 | 0.66541 | 4 | 0 | 3 |
| ATP7B | GABRB1 | 0.655802 | 5 | 0 | 3 |
| ATP7B | POLR3A | 0.653 | 3 | 0 | 3 |
| ATP7B | MANBAL | 0.649206 | 4 | 0 | 3 |
| ATP7B | TCEANC | 0.638035 | 4 | 0 | 3 |
| ATP7B | SLC51A | 0.635693 | 3 | 0 | 3 |
| ATP7B | ERC2 | 0.634176 | 4 | 0 | 3 |
| ATP7B | ATP8A2 | 0.633636 | 4 | 0 | 3 |
| ATP7B | GRIA2 | 0.628212 | 4 | 0 | 3 |
For details and further investigation, click here
