LCTL

 

Full name: lactase like Alias Symbol: KLPH|FLJ33279|KLG
Type: protein-coding gene Cytoband: 15q22.31
Entrez ID: 197021 HGNC ID: HGNC:15583 Ensembl Gene: ENSG00000188501 OMIM ID: 617060
Drug and gene relationship at DGIdb

 

Expression of LCTL:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LCTL 197021 1563899_at -0.0247 0.9176
GSE26886 LCTL 197021 1563899_at 0.0092 0.9250
GSE45670 LCTL 197021 1563899_at 0.1281 0.0389
GSE63941 LCTL 197021 1563899_at 0.1133 0.4049
GSE77861 LCTL 197021 1563899_at -0.0501 0.4676
GSE97050 LCTL 197021 A_33_P3357678 0.5794 0.1720
SRP064894 LCTL 197021 RNAseq 0.3901 0.2133
SRP133303 LCTL 197021 RNAseq 0.3685 0.0877
SRP193095 LCTL 197021 RNAseq 0.2929 0.1046
SRP219564 LCTL 197021 RNAseq 0.2893 0.5492
TCGA LCTL 197021 RNAseq 1.3146 0.0048

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by LCTL expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of LCTL:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LCTL 197021 7 3 20
GSE20123 LCTL 197021 7 3 20
GSE43470 LCTL 197021 4 6 33
GSE46452 LCTL 197021 3 7 49
GSE47630 LCTL 197021 8 10 22
GSE54993 LCTL 197021 5 6 59
GSE54994 LCTL 197021 6 7 40
GSE60625 LCTL 197021 4 0 7
GSE74703 LCTL 197021 4 3 29
GSE74704 LCTL 197021 3 3 14
TCGA LCTL 197021 10 15 71

Total number of gains: 61; Total number of losses: 63; Total Number of normals: 364.  

 

Somatic mutations of LCTL:

 

Generating mutation plots.

 

Highly correlated genes for LCTL:

 

Showing all 9 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LCTLC1GALT10.617765303
LCTLPMCH0.615445303
LCTLWNT7A0.606827303
LCTLACSL30.591457303
LCTLZNF3260.570613303
LCTLKLK50.563511403
LCTLGLMN0.54901503
LCTLCA20.542963303
LCTLMTF20.528841303

For details and further investigation, click here