| Full name: acyl-CoA synthetase long chain family member 3 | Alias Symbol: ACS3|PRO2194 | ||
| Type: protein-coding gene | Cytoband: 2q36.1 | ||
| Entrez ID: 2181 | HGNC ID: HGNC:3570 | Ensembl Gene: ENSG00000123983 | OMIM ID: 602371 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ACSL3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa04920 | Adipocytokine signaling pathway |
Expression of ACSL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACSL3 | 2181 | 201662_s_at | -0.5502 | 0.4023 | |
| GSE20347 | ACSL3 | 2181 | 201661_s_at | -0.7037 | 0.0005 | |
| GSE23400 | ACSL3 | 2181 | 201660_at | -0.4747 | 0.0000 | |
| GSE26886 | ACSL3 | 2181 | 201662_s_at | -0.7984 | 0.0029 | |
| GSE29001 | ACSL3 | 2181 | 201662_s_at | -0.9027 | 0.0079 | |
| GSE38129 | ACSL3 | 2181 | 201661_s_at | -0.6926 | 0.0000 | |
| GSE45670 | ACSL3 | 2181 | 201662_s_at | -0.2125 | 0.1896 | |
| GSE53622 | ACSL3 | 2181 | 120689 | -0.5986 | 0.0000 | |
| GSE53624 | ACSL3 | 2181 | 120689 | -0.6572 | 0.0000 | |
| GSE63941 | ACSL3 | 2181 | 201662_s_at | -0.2136 | 0.5542 | |
| GSE77861 | ACSL3 | 2181 | 201662_s_at | -0.2219 | 0.5305 | |
| GSE97050 | ACSL3 | 2181 | A_24_P248606 | -0.3991 | 0.2641 | |
| SRP007169 | ACSL3 | 2181 | RNAseq | -0.4718 | 0.1986 | |
| SRP008496 | ACSL3 | 2181 | RNAseq | -0.5062 | 0.0074 | |
| SRP064894 | ACSL3 | 2181 | RNAseq | -0.7306 | 0.0000 | |
| SRP133303 | ACSL3 | 2181 | RNAseq | -0.2349 | 0.0607 | |
| SRP159526 | ACSL3 | 2181 | RNAseq | -0.3161 | 0.2223 | |
| SRP193095 | ACSL3 | 2181 | RNAseq | -0.6340 | 0.0000 | |
| SRP219564 | ACSL3 | 2181 | RNAseq | -0.4023 | 0.3448 | |
| TCGA | ACSL3 | 2181 | RNAseq | -0.2621 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ACSL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACSL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACSL3 | 2181 | 2 | 13 | 15 | |
| GSE20123 | ACSL3 | 2181 | 2 | 13 | 15 | |
| GSE43470 | ACSL3 | 2181 | 0 | 7 | 36 | |
| GSE46452 | ACSL3 | 2181 | 0 | 5 | 54 | |
| GSE47630 | ACSL3 | 2181 | 4 | 5 | 31 | |
| GSE54993 | ACSL3 | 2181 | 1 | 2 | 67 | |
| GSE54994 | ACSL3 | 2181 | 8 | 10 | 35 | |
| GSE60625 | ACSL3 | 2181 | 3 | 0 | 8 | |
| GSE74703 | ACSL3 | 2181 | 0 | 6 | 30 | |
| GSE74704 | ACSL3 | 2181 | 2 | 7 | 11 | |
| TCGA | ACSL3 | 2181 | 13 | 27 | 56 |
Total number of gains: 35; Total number of losses: 95; Total Number of normals: 358.
Somatic mutations of ACSL3:
Generating mutation plots.
Highly correlated genes for ACSL3:
Showing top 20/920 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACSL3 | UBE2E2 | 0.812265 | 3 | 0 | 3 |
| ACSL3 | TRIM5 | 0.767051 | 3 | 0 | 3 |
| ACSL3 | SGMS1 | 0.753907 | 3 | 0 | 3 |
| ACSL3 | TRAPPC6B | 0.738991 | 3 | 0 | 3 |
| ACSL3 | DNAJC21 | 0.736486 | 3 | 0 | 3 |
| ACSL3 | TRIP4 | 0.727435 | 5 | 0 | 4 |
| ACSL3 | PNPLA8 | 0.725069 | 3 | 0 | 3 |
| ACSL3 | IPMK | 0.724721 | 4 | 0 | 4 |
| ACSL3 | APEH | 0.720907 | 3 | 0 | 3 |
| ACSL3 | CCNYL1 | 0.718746 | 4 | 0 | 4 |
| ACSL3 | MRPS25 | 0.717013 | 3 | 0 | 3 |
| ACSL3 | BARD1 | 0.713416 | 4 | 0 | 4 |
| ACSL3 | TRNAU1AP | 0.712983 | 3 | 0 | 3 |
| ACSL3 | HNRNPH1 | 0.706802 | 3 | 0 | 3 |
| ACSL3 | MORN2 | 0.705342 | 3 | 0 | 3 |
| ACSL3 | BDKRB2 | 0.705199 | 4 | 0 | 4 |
| ACSL3 | DYNC1I2 | 0.701243 | 3 | 0 | 3 |
| ACSL3 | TAF7 | 0.700497 | 3 | 0 | 3 |
| ACSL3 | SUGT1 | 0.698724 | 4 | 0 | 3 |
| ACSL3 | SPIN4 | 0.69595 | 3 | 0 | 3 |
For details and further investigation, click here
