| Full name: kallikrein related peptidase 5 | Alias Symbol: SCTE|KLK-L2 | ||
| Type: protein-coding gene | Cytoband: 19q13.41 | ||
| Entrez ID: 25818 | HGNC ID: HGNC:6366 | Ensembl Gene: ENSG00000167754 | OMIM ID: 605643 |
| Drug and gene relationship at DGIdb | |||
Expression of KLK5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLK5 | 25818 | 222242_s_at | -0.7567 | 0.6409 | |
| GSE20347 | KLK5 | 25818 | 222242_s_at | -0.7116 | 0.1791 | |
| GSE23400 | KLK5 | 25818 | 222242_s_at | 0.0499 | 0.8567 | |
| GSE26886 | KLK5 | 25818 | 222242_s_at | -1.6482 | 0.0006 | |
| GSE29001 | KLK5 | 25818 | 222242_s_at | -0.4679 | 0.2736 | |
| GSE38129 | KLK5 | 25818 | 222242_s_at | -0.0223 | 0.9684 | |
| GSE45670 | KLK5 | 25818 | 222242_s_at | 2.0830 | 0.0007 | |
| GSE53622 | KLK5 | 25818 | 14757 | 0.4871 | 0.1766 | |
| GSE53624 | KLK5 | 25818 | 14757 | 0.0433 | 0.8728 | |
| GSE63941 | KLK5 | 25818 | 222242_s_at | 1.9557 | 0.3512 | |
| GSE77861 | KLK5 | 25818 | 222242_s_at | -1.0200 | 0.1307 | |
| GSE97050 | KLK5 | 25818 | A_23_P153480 | 2.9767 | 0.1389 | |
| SRP007169 | KLK5 | 25818 | RNAseq | 0.4994 | 0.8196 | |
| SRP008496 | KLK5 | 25818 | RNAseq | 0.1487 | 0.9242 | |
| SRP064894 | KLK5 | 25818 | RNAseq | 1.0662 | 0.0726 | |
| SRP133303 | KLK5 | 25818 | RNAseq | 0.5866 | 0.2294 | |
| SRP159526 | KLK5 | 25818 | RNAseq | -1.7670 | 0.0338 | |
| TCGA | KLK5 | 25818 | RNAseq | 0.8427 | 0.1076 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by KLK5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLK5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLK5 | 25818 | 3 | 4 | 23 | |
| GSE20123 | KLK5 | 25818 | 3 | 3 | 24 | |
| GSE43470 | KLK5 | 25818 | 4 | 11 | 28 | |
| GSE46452 | KLK5 | 25818 | 45 | 1 | 13 | |
| GSE47630 | KLK5 | 25818 | 9 | 6 | 25 | |
| GSE54993 | KLK5 | 25818 | 17 | 4 | 49 | |
| GSE54994 | KLK5 | 25818 | 4 | 14 | 35 | |
| GSE60625 | KLK5 | 25818 | 9 | 0 | 2 | |
| GSE74703 | KLK5 | 25818 | 4 | 7 | 25 | |
| GSE74704 | KLK5 | 25818 | 3 | 1 | 16 | |
| TCGA | KLK5 | 25818 | 15 | 19 | 62 |
Total number of gains: 116; Total number of losses: 70; Total Number of normals: 302.
Somatic mutations of KLK5:
Generating mutation plots.
Highly correlated genes for KLK5:
Showing top 20/216 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLK5 | SH3D21 | 0.692247 | 4 | 0 | 4 |
| KLK5 | PHF7 | 0.680656 | 3 | 0 | 3 |
| KLK5 | MT4 | 0.675832 | 4 | 0 | 4 |
| KLK5 | KLK6 | 0.659524 | 13 | 0 | 12 |
| KLK5 | INO80C | 0.659167 | 3 | 0 | 3 |
| KLK5 | CISH | 0.651951 | 4 | 0 | 4 |
| KLK5 | LYNX1 | 0.644874 | 4 | 0 | 3 |
| KLK5 | DMKN | 0.642771 | 8 | 0 | 8 |
| KLK5 | UBE2D2 | 0.640677 | 3 | 0 | 3 |
| KLK5 | KLK7 | 0.639751 | 12 | 0 | 9 |
| KLK5 | SIGLEC6 | 0.633724 | 3 | 0 | 3 |
| KLK5 | KRTDAP | 0.632434 | 7 | 0 | 6 |
| KLK5 | PPIC | 0.631932 | 4 | 0 | 3 |
| KLK5 | CEACAM19 | 0.627453 | 5 | 0 | 4 |
| KLK5 | IL36RN | 0.625679 | 8 | 0 | 6 |
| KLK5 | IL17RC | 0.625509 | 5 | 0 | 4 |
| KLK5 | VSIG10L | 0.62525 | 3 | 0 | 3 |
| KLK5 | LMF2 | 0.623393 | 3 | 0 | 3 |
| KLK5 | LEPROT | 0.622984 | 3 | 0 | 3 |
| KLK5 | WFDC5 | 0.622059 | 7 | 0 | 5 |
For details and further investigation, click here
