| Full name: pro-melanin concentrating hormone | Alias Symbol: MCH | ||
| Type: protein-coding gene | Cytoband: 12q23.2 | ||
| Entrez ID: 5367 | HGNC ID: HGNC:9109 | Ensembl Gene: ENSG00000183395 | OMIM ID: 176795 |
| Drug and gene relationship at DGIdb | |||
Expression of PMCH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PMCH | 5367 | 206942_s_at | 0.1941 | 0.4709 | |
| GSE20347 | PMCH | 5367 | 206942_s_at | 0.1292 | 0.2194 | |
| GSE23400 | PMCH | 5367 | 206942_s_at | -0.0872 | 0.0100 | |
| GSE26886 | PMCH | 5367 | 206942_s_at | 0.2615 | 0.5929 | |
| GSE29001 | PMCH | 5367 | 206942_s_at | 0.1547 | 0.4925 | |
| GSE38129 | PMCH | 5367 | 206942_s_at | 0.1422 | 0.2186 | |
| GSE45670 | PMCH | 5367 | 206942_s_at | 0.3401 | 0.0054 | |
| GSE63941 | PMCH | 5367 | 206942_s_at | 0.1388 | 0.7975 | |
| GSE77861 | PMCH | 5367 | 206942_s_at | -0.2014 | 0.1110 | |
| GSE97050 | PMCH | 5367 | A_23_P321223 | 0.4331 | 0.1734 | |
| TCGA | PMCH | 5367 | RNAseq | 2.9887 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PMCH expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PMCH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PMCH | 5367 | 3 | 2 | 25 | |
| GSE20123 | PMCH | 5367 | 3 | 2 | 25 | |
| GSE43470 | PMCH | 5367 | 2 | 0 | 41 | |
| GSE46452 | PMCH | 5367 | 9 | 1 | 49 | |
| GSE47630 | PMCH | 5367 | 9 | 1 | 30 | |
| GSE54993 | PMCH | 5367 | 0 | 5 | 65 | |
| GSE54994 | PMCH | 5367 | 4 | 2 | 47 | |
| GSE60625 | PMCH | 5367 | 0 | 0 | 11 | |
| GSE74703 | PMCH | 5367 | 2 | 0 | 34 | |
| GSE74704 | PMCH | 5367 | 1 | 2 | 17 | |
| TCGA | PMCH | 5367 | 18 | 11 | 67 |
Total number of gains: 51; Total number of losses: 26; Total Number of normals: 411.
Somatic mutations of PMCH:
Generating mutation plots.
Highly correlated genes for PMCH:
Showing top 20/33 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PMCH | MTFP1 | 0.703483 | 3 | 0 | 3 |
| PMCH | ADAM12 | 0.692042 | 4 | 0 | 4 |
| PMCH | TXNL4B | 0.649836 | 3 | 0 | 3 |
| PMCH | MAL2 | 0.647578 | 3 | 0 | 3 |
| PMCH | BPNT1 | 0.627081 | 3 | 0 | 3 |
| PMCH | RPS6KB2 | 0.626212 | 3 | 0 | 3 |
| PMCH | C12orf54 | 0.61839 | 3 | 0 | 3 |
| PMCH | LCTL | 0.615445 | 3 | 0 | 3 |
| PMCH | PANK2 | 0.611221 | 3 | 0 | 3 |
| PMCH | LEFTY1 | 0.605314 | 3 | 0 | 3 |
| PMCH | CEMIP | 0.5905 | 3 | 0 | 3 |
| PMCH | NR1H4 | 0.579923 | 3 | 0 | 3 |
| PMCH | KIAA1217 | 0.575258 | 3 | 0 | 3 |
| PMCH | SLAMF8 | 0.574511 | 3 | 0 | 3 |
| PMCH | PON3 | 0.570755 | 3 | 0 | 3 |
| PMCH | ULBP1 | 0.569169 | 4 | 0 | 3 |
| PMCH | HAPLN1 | 0.564791 | 3 | 0 | 3 |
| PMCH | GPR45 | 0.562603 | 5 | 0 | 3 |
| PMCH | TMCO6 | 0.561305 | 4 | 0 | 3 |
| PMCH | CDC25C | 0.557612 | 6 | 0 | 4 |
For details and further investigation, click here
