RPS2

 

Full name: ribosomal protein S2 Alias Symbol: LLREP3|S2
Type: protein-coding gene Cytoband: 16p13.3
Entrez ID: 6187 HGNC ID: HGNC:10404 Ensembl Gene: ENSG00000140988 OMIM ID: 603624
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of RPS2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 RPS2 6187 24848 0.1900 0.0296
GSE53624 RPS2 6187 24848 0.2132 0.0004
GSE97050 RPS2 6187 A_24_P135902 0.2459 0.6478
SRP007169 RPS2 6187 RNAseq -0.9178 0.0054
SRP008496 RPS2 6187 RNAseq -0.7872 0.0091
SRP064894 RPS2 6187 RNAseq -0.3130 0.2868
SRP133303 RPS2 6187 RNAseq 0.0067 0.9664
SRP159526 RPS2 6187 RNAseq -0.2820 0.4410
SRP193095 RPS2 6187 RNAseq -0.5807 0.0001
SRP219564 RPS2 6187 RNAseq 0.0551 0.8751
TCGA RPS2 6187 RNAseq 0.1634 0.0017

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by RPS2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RPS2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RPS2 6187 5 5 20
GSE20123 RPS2 6187 5 4 21
GSE43470 RPS2 6187 4 7 32
GSE46452 RPS2 6187 38 1 20
GSE47630 RPS2 6187 13 6 21
GSE54993 RPS2 6187 3 5 62
GSE54994 RPS2 6187 5 9 39
GSE60625 RPS2 6187 4 0 7
GSE74703 RPS2 6187 4 5 27
GSE74704 RPS2 6187 3 2 15
TCGA RPS2 6187 19 14 63

Total number of gains: 103; Total number of losses: 58; Total Number of normals: 327.  

 

Somatic mutations of RPS2:

 

Generating mutation plots.

 

Highly correlated genes for RPS2:

 

Showing all 11 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RPS2RPL120.759216303
RPS2HMGA10.678729303
RPS2RPL390.665955303
RPS2RPLP00.64149403
RPS2PRMT10.591824303
RPS2PHB20.582704403
RPS2PPIAL4A0.577139303
RPS2RAN0.572324403
RPS2HDGF0.563016403
RPS2RSL1D10.547691403
RPS2RPL7A0.530512403

For details and further investigation, click here