| Full name: high mobility group AT-hook 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p21.31 | ||
| Entrez ID: 3159 | HGNC ID: HGNC:5010 | Ensembl Gene: ENSG00000137309 | OMIM ID: 600701 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of HMGA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMGA1 | 3159 | 206074_s_at | 0.6512 | 0.3679 | |
| GSE20347 | HMGA1 | 3159 | 206074_s_at | 0.2299 | 0.1406 | |
| GSE23400 | HMGA1 | 3159 | 206074_s_at | 0.1706 | 0.1885 | |
| GSE26886 | HMGA1 | 3159 | 206074_s_at | -0.3086 | 0.2489 | |
| GSE29001 | HMGA1 | 3159 | 206074_s_at | -0.3370 | 0.2257 | |
| GSE38129 | HMGA1 | 3159 | 206074_s_at | 0.5872 | 0.0502 | |
| GSE45670 | HMGA1 | 3159 | 206074_s_at | 0.2620 | 0.0933 | |
| GSE53622 | HMGA1 | 3159 | 11270 | 0.1045 | 0.5248 | |
| GSE53624 | HMGA1 | 3159 | 136456 | 0.3130 | 0.0000 | |
| GSE63941 | HMGA1 | 3159 | 206074_s_at | 1.1965 | 0.0252 | |
| GSE77861 | HMGA1 | 3159 | 206074_s_at | 0.3018 | 0.3895 | |
| GSE97050 | HMGA1 | 3159 | A_23_P42331 | 0.8127 | 0.3423 | |
| SRP007169 | HMGA1 | 3159 | RNAseq | -1.7998 | 0.0002 | |
| SRP008496 | HMGA1 | 3159 | RNAseq | -1.8520 | 0.0000 | |
| SRP064894 | HMGA1 | 3159 | RNAseq | -1.1129 | 0.0001 | |
| SRP133303 | HMGA1 | 3159 | RNAseq | -0.0379 | 0.8548 | |
| SRP159526 | HMGA1 | 3159 | RNAseq | -0.0102 | 0.9779 | |
| SRP193095 | HMGA1 | 3159 | RNAseq | -0.2871 | 0.1321 | |
| SRP219564 | HMGA1 | 3159 | RNAseq | -0.2786 | 0.7264 | |
| TCGA | HMGA1 | 3159 | RNAseq | 0.3928 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by HMGA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMGA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMGA1 | 3159 | 5 | 0 | 25 | |
| GSE20123 | HMGA1 | 3159 | 5 | 0 | 25 | |
| GSE43470 | HMGA1 | 3159 | 7 | 1 | 35 | |
| GSE46452 | HMGA1 | 3159 | 2 | 9 | 48 | |
| GSE47630 | HMGA1 | 3159 | 8 | 4 | 28 | |
| GSE54993 | HMGA1 | 3159 | 3 | 1 | 66 | |
| GSE54994 | HMGA1 | 3159 | 11 | 4 | 38 | |
| GSE60625 | HMGA1 | 3159 | 1 | 0 | 10 | |
| GSE74703 | HMGA1 | 3159 | 6 | 0 | 30 | |
| GSE74704 | HMGA1 | 3159 | 2 | 0 | 18 | |
| TCGA | HMGA1 | 3159 | 16 | 15 | 65 |
Total number of gains: 66; Total number of losses: 34; Total Number of normals: 388.
Somatic mutations of HMGA1:
Generating mutation plots.
Highly correlated genes for HMGA1:
Showing top 20/511 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMGA1 | TBCC | 0.749219 | 4 | 0 | 4 |
| HMGA1 | DCAF12 | 0.743598 | 3 | 0 | 3 |
| HMGA1 | SLC39A11 | 0.731447 | 3 | 0 | 3 |
| HMGA1 | RPS2 | 0.678729 | 3 | 0 | 3 |
| HMGA1 | CDK5R1 | 0.671749 | 4 | 0 | 3 |
| HMGA1 | KDF1 | 0.670874 | 4 | 0 | 3 |
| HMGA1 | ETNK1 | 0.669759 | 5 | 0 | 4 |
| HMGA1 | C21orf58 | 0.668173 | 3 | 0 | 3 |
| HMGA1 | TFIP11 | 0.663668 | 3 | 0 | 3 |
| HMGA1 | RAB38 | 0.662426 | 5 | 0 | 4 |
| HMGA1 | DIAPH1 | 0.660109 | 5 | 0 | 5 |
| HMGA1 | VSNL1 | 0.658289 | 4 | 0 | 4 |
| HMGA1 | WDR77 | 0.656764 | 5 | 0 | 5 |
| HMGA1 | NHSL1 | 0.654863 | 3 | 0 | 3 |
| HMGA1 | TMEM62 | 0.653095 | 3 | 0 | 3 |
| HMGA1 | KIAA1522 | 0.652802 | 5 | 0 | 3 |
| HMGA1 | PDCD6 | 0.652626 | 4 | 0 | 3 |
| HMGA1 | ARNTL2 | 0.651939 | 6 | 0 | 5 |
| HMGA1 | E2F2 | 0.651495 | 6 | 0 | 4 |
| HMGA1 | VANGL2 | 0.651097 | 3 | 0 | 3 |
For details and further investigation, click here
