PHB2

 

Full name: prohibitin 2 Alias Symbol: REA|BCAP37|Bap37|p22
Type: protein-coding gene Cytoband: 12p13.31
Entrez ID: 11331 HGNC ID: HGNC:30306 Ensembl Gene: ENSG00000215021 OMIM ID: 610704
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of PHB2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PHB2 11331 201600_at 0.0990 0.8841
GSE20347 PHB2 11331 201600_at 0.4631 0.0070
GSE23400 PHB2 11331 201600_at 0.4986 0.0000
GSE26886 PHB2 11331 201600_at 0.8007 0.0050
GSE29001 PHB2 11331 201600_at 0.6489 0.0382
GSE38129 PHB2 11331 201600_at 0.3854 0.0004
GSE45670 PHB2 11331 201600_at 0.2171 0.3160
GSE53622 PHB2 11331 137073 0.4617 0.0000
GSE53624 PHB2 11331 137073 0.6452 0.0000
GSE63941 PHB2 11331 201600_at 1.7585 0.0001
GSE77861 PHB2 11331 201600_at 0.4858 0.0701
GSE97050 PHB2 11331 A_33_P3368328 0.5621 0.1476
SRP007169 PHB2 11331 RNAseq -0.0257 0.9386
SRP008496 PHB2 11331 RNAseq 0.1457 0.3692
SRP064894 PHB2 11331 RNAseq 0.0157 0.9415
SRP133303 PHB2 11331 RNAseq 0.3921 0.0700
SRP159526 PHB2 11331 RNAseq 0.2268 0.3297
SRP193095 PHB2 11331 RNAseq -0.0577 0.6426
SRP219564 PHB2 11331 RNAseq 0.1047 0.7087
TCGA PHB2 11331 RNAseq 0.0991 0.0321

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by PHB2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PHB2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PHB2 11331 9 3 18
GSE20123 PHB2 11331 9 3 18
GSE43470 PHB2 11331 8 3 32
GSE46452 PHB2 11331 10 1 48
GSE47630 PHB2 11331 12 2 26
GSE54993 PHB2 11331 1 10 59
GSE54994 PHB2 11331 10 2 41
GSE60625 PHB2 11331 0 1 10
GSE74703 PHB2 11331 7 2 27
GSE74704 PHB2 11331 5 3 12
TCGA PHB2 11331 40 6 50

Total number of gains: 111; Total number of losses: 36; Total Number of normals: 341.  

 

Somatic mutations of PHB2:

 

Generating mutation plots.

 

Highly correlated genes for PHB2:

 

Showing top 20/1340 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PHB2MRPL380.801479404
PHB2EMG10.75420411011
PHB2MLF20.74423613013
PHB2CCDC770.739744606
PHB2NOP20.73907911011
PHB2CDK40.7328213013
PHB2HAS30.727156303
PHB2AFTPH0.723212303
PHB2MRPL510.72291907
PHB2ALG10B0.715578303
PHB2MTBP0.712077505
PHB2ABHD20.71098303
PHB2M6PR0.7105981008
PHB2WBP110.70545713012
PHB2PDIA60.702415908
PHB2ANAPC10.698128303
PHB2PTCD10.697386303
PHB2PAXIP1-AS10.696085404
PHB2NOP560.693796303
PHB2NCAPD20.69357913013

For details and further investigation, click here