| Full name: signal transducer and activator of transcription 5A | Alias Symbol: MGF | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 6776 | HGNC ID: HGNC:11366 | Ensembl Gene: ENSG00000126561 | OMIM ID: 601511 |
| Drug and gene relationship at DGIdb | |||
STAT5A involved pathways:
Expression of STAT5A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STAT5A | 6776 | 203010_at | 0.1246 | 0.7526 | |
| GSE20347 | STAT5A | 6776 | 203010_at | -0.0729 | 0.5448 | |
| GSE23400 | STAT5A | 6776 | 203010_at | -0.0952 | 0.0188 | |
| GSE26886 | STAT5A | 6776 | 203010_at | -0.1889 | 0.2515 | |
| GSE29001 | STAT5A | 6776 | 203010_at | 0.1154 | 0.6140 | |
| GSE38129 | STAT5A | 6776 | 203010_at | -0.2918 | 0.0924 | |
| GSE45670 | STAT5A | 6776 | 203010_at | -0.1633 | 0.3120 | |
| GSE53622 | STAT5A | 6776 | 46811 | -0.4161 | 0.0058 | |
| GSE53624 | STAT5A | 6776 | 46811 | -0.1574 | 0.2184 | |
| GSE63941 | STAT5A | 6776 | 203010_at | -1.0276 | 0.0018 | |
| GSE77861 | STAT5A | 6776 | 203010_at | -0.0987 | 0.3435 | |
| GSE97050 | STAT5A | 6776 | A_23_P207367 | 0.1149 | 0.5574 | |
| SRP007169 | STAT5A | 6776 | RNAseq | 0.5463 | 0.4825 | |
| SRP064894 | STAT5A | 6776 | RNAseq | 0.4948 | 0.0562 | |
| SRP133303 | STAT5A | 6776 | RNAseq | -0.1762 | 0.4909 | |
| SRP159526 | STAT5A | 6776 | RNAseq | -0.2708 | 0.4838 | |
| SRP193095 | STAT5A | 6776 | RNAseq | 0.5678 | 0.0002 | |
| SRP219564 | STAT5A | 6776 | RNAseq | 0.4799 | 0.0715 | |
| TCGA | STAT5A | 6776 | RNAseq | -0.0932 | 0.2785 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by STAT5A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STAT5A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STAT5A | 6776 | 6 | 2 | 22 | |
| GSE20123 | STAT5A | 6776 | 6 | 2 | 22 | |
| GSE43470 | STAT5A | 6776 | 1 | 2 | 40 | |
| GSE46452 | STAT5A | 6776 | 34 | 0 | 25 | |
| GSE47630 | STAT5A | 6776 | 8 | 1 | 31 | |
| GSE54993 | STAT5A | 6776 | 3 | 4 | 63 | |
| GSE54994 | STAT5A | 6776 | 8 | 5 | 40 | |
| GSE60625 | STAT5A | 6776 | 4 | 0 | 7 | |
| GSE74703 | STAT5A | 6776 | 1 | 1 | 34 | |
| GSE74704 | STAT5A | 6776 | 4 | 1 | 15 | |
| TCGA | STAT5A | 6776 | 23 | 6 | 67 |
Total number of gains: 98; Total number of losses: 24; Total Number of normals: 366.
Somatic mutations of STAT5A:
Generating mutation plots.
Highly correlated genes for STAT5A:
Showing top 20/824 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STAT5A | LIMD2 | 0.801582 | 3 | 0 | 3 |
| STAT5A | FCHO1 | 0.780312 | 3 | 0 | 3 |
| STAT5A | SIDT2 | 0.761441 | 4 | 0 | 4 |
| STAT5A | GIMAP5 | 0.743632 | 4 | 0 | 4 |
| STAT5A | NFIX | 0.735196 | 3 | 0 | 3 |
| STAT5A | TNFSF12 | 0.731761 | 3 | 0 | 3 |
| STAT5A | NFASC | 0.724111 | 4 | 0 | 4 |
| STAT5A | ZFAND3 | 0.723504 | 3 | 0 | 3 |
| STAT5A | TADA2B | 0.721064 | 4 | 0 | 4 |
| STAT5A | AP3S2 | 0.719851 | 3 | 0 | 3 |
| STAT5A | KBTBD8 | 0.719116 | 5 | 0 | 5 |
| STAT5A | COL8A1 | 0.717533 | 3 | 0 | 3 |
| STAT5A | VSTM4 | 0.716426 | 6 | 0 | 6 |
| STAT5A | CCDC97 | 0.715109 | 3 | 0 | 3 |
| STAT5A | BBX | 0.714361 | 3 | 0 | 3 |
| STAT5A | UHRF2 | 0.712815 | 3 | 0 | 3 |
| STAT5A | C19orf38 | 0.712673 | 3 | 0 | 3 |
| STAT5A | TCTN1 | 0.710916 | 4 | 0 | 3 |
| STAT5A | ARHGAP17 | 0.710708 | 4 | 0 | 3 |
| STAT5A | TAGAP | 0.709554 | 5 | 0 | 5 |
For details and further investigation, click here
