| Full name: phosphatidylinositol 4-kinase beta | Alias Symbol: PI4K-BETA|pi4K92 | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 5298 | HGNC ID: HGNC:8984 | Ensembl Gene: ENSG00000143393 | OMIM ID: 602758 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PI4KB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PI4KB | 5298 | 206138_s_at | 0.2826 | 0.3398 | |
| GSE20347 | PI4KB | 5298 | 206138_s_at | 0.0592 | 0.4172 | |
| GSE23400 | PI4KB | 5298 | 206138_s_at | -0.0280 | 0.5513 | |
| GSE26886 | PI4KB | 5298 | 206138_s_at | -0.2046 | 0.2096 | |
| GSE29001 | PI4KB | 5298 | 206138_s_at | -0.0325 | 0.8989 | |
| GSE38129 | PI4KB | 5298 | 206138_s_at | 0.0497 | 0.5645 | |
| GSE45670 | PI4KB | 5298 | 206138_s_at | 0.0314 | 0.8080 | |
| GSE53622 | PI4KB | 5298 | 135918 | -0.0578 | 0.2091 | |
| GSE53624 | PI4KB | 5298 | 135918 | -0.0569 | 0.3253 | |
| GSE63941 | PI4KB | 5298 | 206138_s_at | 0.4701 | 0.1289 | |
| GSE77861 | PI4KB | 5298 | 206138_s_at | 0.0517 | 0.6694 | |
| GSE97050 | PI4KB | 5298 | A_23_P314726 | -0.0388 | 0.8583 | |
| SRP007169 | PI4KB | 5298 | RNAseq | -0.9098 | 0.0018 | |
| SRP008496 | PI4KB | 5298 | RNAseq | -0.6837 | 0.0001 | |
| SRP064894 | PI4KB | 5298 | RNAseq | 0.0067 | 0.9690 | |
| SRP133303 | PI4KB | 5298 | RNAseq | -0.1738 | 0.2295 | |
| SRP159526 | PI4KB | 5298 | RNAseq | 0.2963 | 0.1603 | |
| SRP193095 | PI4KB | 5298 | RNAseq | -0.1081 | 0.2814 | |
| SRP219564 | PI4KB | 5298 | RNAseq | 0.0214 | 0.9274 | |
| TCGA | PI4KB | 5298 | RNAseq | -0.0524 | 0.2334 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PI4KB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PI4KB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PI4KB | 5298 | 14 | 0 | 16 | |
| GSE20123 | PI4KB | 5298 | 14 | 0 | 16 | |
| GSE43470 | PI4KB | 5298 | 6 | 1 | 36 | |
| GSE46452 | PI4KB | 5298 | 2 | 1 | 56 | |
| GSE47630 | PI4KB | 5298 | 14 | 0 | 26 | |
| GSE54993 | PI4KB | 5298 | 0 | 4 | 66 | |
| GSE54994 | PI4KB | 5298 | 15 | 0 | 38 | |
| GSE60625 | PI4KB | 5298 | 0 | 0 | 11 | |
| GSE74703 | PI4KB | 5298 | 6 | 1 | 29 | |
| GSE74704 | PI4KB | 5298 | 7 | 0 | 13 | |
| TCGA | PI4KB | 5298 | 37 | 2 | 57 |
Total number of gains: 115; Total number of losses: 9; Total Number of normals: 364.
Somatic mutations of PI4KB:
Generating mutation plots.
Highly correlated genes for PI4KB:
Showing top 20/219 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PI4KB | NAA10 | 0.754348 | 3 | 0 | 3 |
| PI4KB | NPRL2 | 0.742331 | 3 | 0 | 3 |
| PI4KB | SSBP4 | 0.732157 | 3 | 0 | 3 |
| PI4KB | KCTD15 | 0.7275 | 3 | 0 | 3 |
| PI4KB | NLK | 0.726193 | 3 | 0 | 3 |
| PI4KB | RAB3A | 0.71594 | 3 | 0 | 3 |
| PI4KB | IQSEC1 | 0.699948 | 3 | 0 | 3 |
| PI4KB | SLC39A3 | 0.69581 | 3 | 0 | 3 |
| PI4KB | EI24 | 0.695543 | 3 | 0 | 3 |
| PI4KB | MRPS14 | 0.694247 | 5 | 0 | 5 |
| PI4KB | PRKACA | 0.689633 | 3 | 0 | 3 |
| PI4KB | BEST1 | 0.687952 | 3 | 0 | 3 |
| PI4KB | NPFF | 0.685119 | 3 | 0 | 3 |
| PI4KB | UBL7 | 0.680885 | 3 | 0 | 3 |
| PI4KB | CASKIN2 | 0.677249 | 3 | 0 | 3 |
| PI4KB | EXOSC5 | 0.675895 | 3 | 0 | 3 |
| PI4KB | STRADA | 0.673785 | 3 | 0 | 3 |
| PI4KB | PIGS | 0.67265 | 3 | 0 | 3 |
| PI4KB | GUK1 | 0.671538 | 3 | 0 | 3 |
| PI4KB | DDA1 | 0.664494 | 3 | 0 | 3 |
For details and further investigation, click here
