IYD

 

Full name: iodotyrosine deiodinase Alias Symbol: dJ422F24.1|DEHAL1
Type: protein-coding gene Cytoband: 6q25.1
Entrez ID: 389434 HGNC ID: HGNC:21071 Ensembl Gene: ENSG00000009765 OMIM ID: 612025
Drug and gene relationship at DGIdb

 

Expression of IYD:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IYD 389434 231070_at -0.0572 0.8797
GSE26886 IYD 389434 231070_at 0.0095 0.9269
GSE45670 IYD 389434 231070_at 0.0575 0.3288
GSE53622 IYD 389434 99034 -0.2657 0.2673
GSE53624 IYD 389434 27000 -1.2479 0.0000
GSE63941 IYD 389434 231070_at 0.0052 0.9859
GSE77861 IYD 389434 231070_at 0.0259 0.7492
SRP133303 IYD 389434 RNAseq 0.3435 0.0062
SRP159526 IYD 389434 RNAseq 0.1296 0.7074
SRP193095 IYD 389434 RNAseq -0.1704 0.5002
SRP219564 IYD 389434 RNAseq 0.4254 0.3772
TCGA IYD 389434 RNAseq -3.1132 0.0000

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by IYD expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IYD:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IYD 389434 2 4 24
GSE20123 IYD 389434 2 3 25
GSE43470 IYD 389434 4 0 39
GSE46452 IYD 389434 3 10 46
GSE47630 IYD 389434 9 4 27
GSE54993 IYD 389434 3 2 65
GSE54994 IYD 389434 8 8 37
GSE60625 IYD 389434 0 1 10
GSE74703 IYD 389434 4 0 32
GSE74704 IYD 389434 0 1 19
TCGA IYD 389434 12 20 64

Total number of gains: 47; Total number of losses: 53; Total Number of normals: 388.  

 

Somatic mutations of IYD:

 

Generating mutation plots.

 

Highly correlated genes for IYD:

 

Showing all 9 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IYDNOL40.656942303
IYDCHST90.651949303
IYDBCAS10.580618503
IYDCAPN130.574169303
IYDCP0.564109303
IYDFAM3B0.557096303
IYDFMO50.55655505
IYDLGALS40.517698403
IYDTMPRSS20.501725503

For details and further investigation, click here