| Full name: transmembrane serine protease 2 | Alias Symbol: PRSS10 | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 7113 | HGNC ID: HGNC:11876 | Ensembl Gene: ENSG00000184012 | OMIM ID: 602060 |
| Drug and gene relationship at DGIdb | |||
Expression of TMPRSS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMPRSS2 | 7113 | 226553_at | -0.5555 | 0.6429 | |
| GSE20347 | TMPRSS2 | 7113 | 205102_at | -0.1682 | 0.1649 | |
| GSE23400 | TMPRSS2 | 7113 | 205102_at | -0.3909 | 0.0000 | |
| GSE26886 | TMPRSS2 | 7113 | 226553_at | -3.7552 | 0.0000 | |
| GSE29001 | TMPRSS2 | 7113 | 211689_s_at | -3.2618 | 0.0000 | |
| GSE38129 | TMPRSS2 | 7113 | 205102_at | -0.3284 | 0.0031 | |
| GSE45670 | TMPRSS2 | 7113 | 226553_at | -0.0333 | 0.9552 | |
| GSE53622 | TMPRSS2 | 7113 | 29275 | -2.8141 | 0.0000 | |
| GSE53624 | TMPRSS2 | 7113 | 29275 | -3.6283 | 0.0000 | |
| GSE63941 | TMPRSS2 | 7113 | 226553_at | 0.6387 | 0.1814 | |
| GSE77861 | TMPRSS2 | 7113 | 226553_at | -1.4423 | 0.0036 | |
| SRP007169 | TMPRSS2 | 7113 | RNAseq | -4.9981 | 0.0000 | |
| SRP008496 | TMPRSS2 | 7113 | RNAseq | -5.8224 | 0.0000 | |
| SRP064894 | TMPRSS2 | 7113 | RNAseq | -3.2909 | 0.0000 | |
| SRP133303 | TMPRSS2 | 7113 | RNAseq | -2.6280 | 0.0000 | |
| SRP159526 | TMPRSS2 | 7113 | RNAseq | -3.6053 | 0.0000 | |
| SRP193095 | TMPRSS2 | 7113 | RNAseq | -2.3084 | 0.0000 | |
| SRP219564 | TMPRSS2 | 7113 | RNAseq | -3.5051 | 0.0013 | |
| TCGA | TMPRSS2 | 7113 | RNAseq | -1.6520 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by TMPRSS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMPRSS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMPRSS2 | 7113 | 2 | 8 | 20 | |
| GSE20123 | TMPRSS2 | 7113 | 2 | 8 | 20 | |
| GSE43470 | TMPRSS2 | 7113 | 0 | 13 | 30 | |
| GSE46452 | TMPRSS2 | 7113 | 1 | 21 | 37 | |
| GSE47630 | TMPRSS2 | 7113 | 6 | 17 | 17 | |
| GSE54993 | TMPRSS2 | 7113 | 8 | 1 | 61 | |
| GSE54994 | TMPRSS2 | 7113 | 3 | 8 | 42 | |
| GSE60625 | TMPRSS2 | 7113 | 0 | 0 | 11 | |
| GSE74703 | TMPRSS2 | 7113 | 0 | 10 | 26 | |
| GSE74704 | TMPRSS2 | 7113 | 1 | 4 | 15 | |
| TCGA | TMPRSS2 | 7113 | 7 | 41 | 48 |
Total number of gains: 30; Total number of losses: 131; Total Number of normals: 327.
Somatic mutations of TMPRSS2:
Generating mutation plots.
Highly correlated genes for TMPRSS2:
Showing top 20/1499 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMPRSS2 | C5orf66-AS1 | 0.838091 | 6 | 0 | 6 |
| TMPRSS2 | SPAG17 | 0.833076 | 3 | 0 | 3 |
| TMPRSS2 | TMEM234 | 0.817475 | 3 | 0 | 3 |
| TMPRSS2 | PCBP1-AS1 | 0.816228 | 3 | 0 | 3 |
| TMPRSS2 | MACC1 | 0.814859 | 6 | 0 | 6 |
| TMPRSS2 | GPT2 | 0.8137 | 5 | 0 | 5 |
| TMPRSS2 | VSIG10L | 0.796402 | 5 | 0 | 5 |
| TMPRSS2 | KLB | 0.792523 | 6 | 0 | 6 |
| TMPRSS2 | FCHO2 | 0.78894 | 5 | 0 | 5 |
| TMPRSS2 | FAM3B | 0.773013 | 8 | 0 | 7 |
| TMPRSS2 | DNAJC5 | 0.771862 | 3 | 0 | 3 |
| TMPRSS2 | FAM3D | 0.77176 | 8 | 0 | 7 |
| TMPRSS2 | FAM214A | 0.76964 | 6 | 0 | 5 |
| TMPRSS2 | SMIM5 | 0.768009 | 6 | 0 | 6 |
| TMPRSS2 | ATP13A4 | 0.763527 | 7 | 0 | 7 |
| TMPRSS2 | MYO5B | 0.762981 | 6 | 0 | 6 |
| TMPRSS2 | PRSS27 | 0.762048 | 7 | 0 | 6 |
| TMPRSS2 | AKTIP | 0.756728 | 4 | 0 | 4 |
| TMPRSS2 | TPRG1 | 0.754769 | 6 | 0 | 6 |
| TMPRSS2 | MUC20 | 0.753723 | 8 | 0 | 7 |
For details and further investigation, click here
