| Full name: melanocortin 3 receptor | Alias Symbol: MC3 | ||
| Type: protein-coding gene | Cytoband: 20q13.2 | ||
| Entrez ID: 4159 | HGNC ID: HGNC:6931 | Ensembl Gene: ENSG00000124089 | OMIM ID: 155540 |
| Drug and gene relationship at DGIdb | |||
Expression of MC3R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MC3R | 4159 | 221442_at | -0.0765 | 0.7441 | |
| GSE20347 | MC3R | 4159 | 221442_at | -0.1197 | 0.0275 | |
| GSE23400 | MC3R | 4159 | 221442_at | -0.0779 | 0.0021 | |
| GSE26886 | MC3R | 4159 | 221442_at | 0.1006 | 0.3198 | |
| GSE29001 | MC3R | 4159 | 221442_at | -0.0583 | 0.6181 | |
| GSE38129 | MC3R | 4159 | 221442_at | -0.1180 | 0.0313 | |
| GSE45670 | MC3R | 4159 | 221442_at | 0.0001 | 0.9992 | |
| GSE53622 | MC3R | 4159 | 55266 | 0.3328 | 0.0018 | |
| GSE53624 | MC3R | 4159 | 55266 | 0.2008 | 0.0138 | |
| GSE63941 | MC3R | 4159 | 221442_at | 0.1099 | 0.2937 | |
| GSE77861 | MC3R | 4159 | 221442_at | -0.1240 | 0.1636 | |
| GSE97050 | MC3R | 4159 | A_23_P258525 | 0.1163 | 0.6616 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MC3R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MC3R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MC3R | 4159 | 15 | 1 | 14 | |
| GSE20123 | MC3R | 4159 | 15 | 1 | 14 | |
| GSE43470 | MC3R | 4159 | 13 | 0 | 30 | |
| GSE46452 | MC3R | 4159 | 29 | 0 | 30 | |
| GSE47630 | MC3R | 4159 | 24 | 1 | 15 | |
| GSE54993 | MC3R | 4159 | 0 | 17 | 53 | |
| GSE54994 | MC3R | 4159 | 27 | 0 | 26 | |
| GSE60625 | MC3R | 4159 | 0 | 0 | 11 | |
| GSE74703 | MC3R | 4159 | 11 | 0 | 25 | |
| GSE74704 | MC3R | 4159 | 12 | 0 | 8 | |
| TCGA | MC3R | 4159 | 44 | 4 | 48 |
Total number of gains: 190; Total number of losses: 24; Total Number of normals: 274.
Somatic mutations of MC3R:
Generating mutation plots.
Highly correlated genes for MC3R:
Showing top 20/805 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MC3R | STRC | 0.852949 | 3 | 0 | 3 |
| MC3R | TMEM235 | 0.815754 | 3 | 0 | 3 |
| MC3R | DCDC1 | 0.809308 | 3 | 0 | 3 |
| MC3R | C9orf153 | 0.805846 | 3 | 0 | 3 |
| MC3R | ZNF527 | 0.780864 | 3 | 0 | 3 |
| MC3R | PLA2G2C | 0.77159 | 3 | 0 | 3 |
| MC3R | TSPAN11 | 0.768658 | 4 | 0 | 4 |
| MC3R | OR4D6 | 0.76734 | 3 | 0 | 3 |
| MC3R | C2CD4D | 0.761398 | 3 | 0 | 3 |
| MC3R | KIRREL2 | 0.756426 | 3 | 0 | 3 |
| MC3R | C1QL2 | 0.755646 | 3 | 0 | 3 |
| MC3R | SLC22A31 | 0.753685 | 4 | 0 | 4 |
| MC3R | BTBD19 | 0.751307 | 3 | 0 | 3 |
| MC3R | KRTAP10-12 | 0.749673 | 3 | 0 | 3 |
| MC3R | MRGPRG | 0.747892 | 3 | 0 | 3 |
| MC3R | OR1J4 | 0.744317 | 4 | 0 | 4 |
| MC3R | YY2 | 0.740178 | 3 | 0 | 3 |
| MC3R | KCTD19 | 0.7358 | 4 | 0 | 4 |
| MC3R | FAM110B | 0.731864 | 3 | 0 | 3 |
| MC3R | BBC3 | 0.731627 | 3 | 0 | 3 |
For details and further investigation, click here
