| Full name: BCL2 binding component 3 | Alias Symbol: JFY1|PUMA | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 27113 | HGNC ID: HGNC:17868 | Ensembl Gene: ENSG00000105327 | OMIM ID: 605854 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
BBC3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway | |
| hsa04210 | Apoptosis | |
| hsa04390 | Hippo signaling pathway |
Expression of BBC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | BBC3 | 27113 | 74273 | 0.2108 | 0.0085 | |
| GSE53624 | BBC3 | 27113 | 74273 | 0.1406 | 0.0868 | |
| GSE97050 | BBC3 | 27113 | A_23_P382775 | -0.2663 | 0.2473 | |
| SRP064894 | BBC3 | 27113 | RNAseq | 1.2916 | 0.0001 | |
| SRP133303 | BBC3 | 27113 | RNAseq | 1.0387 | 0.0000 | |
| SRP159526 | BBC3 | 27113 | RNAseq | 1.3890 | 0.0023 | |
| SRP193095 | BBC3 | 27113 | RNAseq | 1.3623 | 0.0000 | |
| SRP219564 | BBC3 | 27113 | RNAseq | 1.1372 | 0.0258 | |
| TCGA | BBC3 | 27113 | RNAseq | 0.3446 | 0.0051 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by BBC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BBC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BBC3 | 27113 | 4 | 4 | 22 | |
| GSE20123 | BBC3 | 27113 | 4 | 3 | 23 | |
| GSE43470 | BBC3 | 27113 | 3 | 11 | 29 | |
| GSE46452 | BBC3 | 27113 | 45 | 1 | 13 | |
| GSE47630 | BBC3 | 27113 | 8 | 7 | 25 | |
| GSE54993 | BBC3 | 27113 | 17 | 4 | 49 | |
| GSE54994 | BBC3 | 27113 | 4 | 14 | 35 | |
| GSE60625 | BBC3 | 27113 | 9 | 0 | 2 | |
| GSE74703 | BBC3 | 27113 | 3 | 7 | 26 | |
| GSE74704 | BBC3 | 27113 | 4 | 1 | 15 | |
| TCGA | BBC3 | 27113 | 15 | 18 | 63 |
Total number of gains: 116; Total number of losses: 70; Total Number of normals: 302.
Somatic mutations of BBC3:
Generating mutation plots.
Highly correlated genes for BBC3:
Showing top 20/294 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BBC3 | CLTCL1 | 0.843321 | 3 | 0 | 3 |
| BBC3 | DCDC1 | 0.83908 | 3 | 0 | 3 |
| BBC3 | TXNDC2 | 0.832558 | 3 | 0 | 3 |
| BBC3 | PAX6 | 0.829924 | 3 | 0 | 3 |
| BBC3 | CIB3 | 0.824317 | 3 | 0 | 3 |
| BBC3 | NKX6-3 | 0.823459 | 3 | 0 | 3 |
| BBC3 | FBRSL1 | 0.823331 | 3 | 0 | 3 |
| BBC3 | SERPINA10 | 0.823206 | 3 | 0 | 3 |
| BBC3 | KCNH3 | 0.822659 | 3 | 0 | 3 |
| BBC3 | RBM43 | 0.821657 | 3 | 0 | 3 |
| BBC3 | PLA2G2D | 0.821122 | 3 | 0 | 3 |
| BBC3 | FOXE3 | 0.81969 | 3 | 0 | 3 |
| BBC3 | GJD4 | 0.816346 | 3 | 0 | 3 |
| BBC3 | YY2 | 0.815911 | 3 | 0 | 3 |
| BBC3 | SIM1 | 0.815426 | 3 | 0 | 3 |
| BBC3 | GPR182 | 0.815117 | 3 | 0 | 3 |
| BBC3 | CPLX2 | 0.81489 | 3 | 0 | 3 |
| BBC3 | RASL10B | 0.814333 | 3 | 0 | 3 |
| BBC3 | INSC | 0.81371 | 3 | 0 | 3 |
| BBC3 | PGP | 0.813226 | 3 | 0 | 3 |
For details and further investigation, click here
