MED21

 

Full name: mediator complex subunit 21 Alias Symbol: SRB7
Type: protein-coding gene Cytoband: 12p12
Entrez ID: 9412 HGNC ID: HGNC:11473 Ensembl Gene: ENSG00000152944 OMIM ID: 603800
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of MED21:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 MED21 9412 62047 -0.4076 0.0000
GSE53624 MED21 9412 30237 -0.0760 0.2966
GSE97050 MED21 9412 A_33_P3400547 -0.5504 0.1856
SRP007169 MED21 9412 RNAseq -0.2036 0.5981
SRP008496 MED21 9412 RNAseq 0.2324 0.5234
SRP064894 MED21 9412 RNAseq -0.3590 0.0237
SRP133303 MED21 9412 RNAseq 0.1632 0.3556
SRP159526 MED21 9412 RNAseq -0.4631 0.0288
SRP193095 MED21 9412 RNAseq -0.3036 0.0559
SRP219564 MED21 9412 RNAseq -0.2197 0.5384
TCGA MED21 9412 RNAseq 0.0523 0.3351

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by MED21 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MED21:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MED21 9412 10 1 19
GSE20123 MED21 9412 10 1 19
GSE43470 MED21 9412 9 4 30
GSE46452 MED21 9412 10 1 48
GSE47630 MED21 9412 14 0 26
GSE54993 MED21 9412 0 9 61
GSE54994 MED21 9412 10 3 40
GSE60625 MED21 9412 0 1 10
GSE74703 MED21 9412 9 3 24
GSE74704 MED21 9412 5 1 14
TCGA MED21 9412 43 6 47

Total number of gains: 120; Total number of losses: 30; Total Number of normals: 338.  

 

Somatic mutations of MED21:

 

Generating mutation plots.

 

Highly correlated genes for MED21:

 

Showing all 10 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MED21ERGIC20.705343303
MED21MRPS350.703153303
MED21KIAA11910.691147303
MED21COQ70.663627303
MED21CHCHD40.663536303
MED21FOXJ20.654092303
MED21PLEKHA50.65172303
MED21ARID20.627011403
MED21FH0.618743403
MED21KCTD60.612632403

For details and further investigation, click here