| Full name: mitochondrial ribosomal protein S35 | Alias Symbol: MRPS28|MDS023 | ||
| Type: protein-coding gene | Cytoband: 12p11.22 | ||
| Entrez ID: 60488 | HGNC ID: HGNC:16635 | Ensembl Gene: ENSG00000061794 | OMIM ID: 611995 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPS35:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPS35 | 60488 | 217942_at | 0.0503 | 0.9284 | |
| GSE20347 | MRPS35 | 60488 | 217942_at | 0.3923 | 0.0611 | |
| GSE23400 | MRPS35 | 60488 | 217942_at | 0.2417 | 0.0001 | |
| GSE26886 | MRPS35 | 60488 | 217942_at | 0.4970 | 0.0057 | |
| GSE29001 | MRPS35 | 60488 | 217942_at | 0.1490 | 0.7108 | |
| GSE38129 | MRPS35 | 60488 | 217942_at | 0.4504 | 0.0077 | |
| GSE45670 | MRPS35 | 60488 | 217942_at | 0.2002 | 0.2922 | |
| GSE53622 | MRPS35 | 60488 | 35771 | -0.0508 | 0.5205 | |
| GSE53624 | MRPS35 | 60488 | 35771 | 0.1849 | 0.0011 | |
| GSE63941 | MRPS35 | 60488 | 217942_at | 0.3836 | 0.3906 | |
| GSE77861 | MRPS35 | 60488 | 217942_at | 0.2785 | 0.0641 | |
| GSE97050 | MRPS35 | 60488 | A_23_P25073 | 0.0835 | 0.7449 | |
| SRP007169 | MRPS35 | 60488 | RNAseq | 0.1093 | 0.7609 | |
| SRP008496 | MRPS35 | 60488 | RNAseq | 0.1259 | 0.6216 | |
| SRP064894 | MRPS35 | 60488 | RNAseq | -0.1522 | 0.3198 | |
| SRP133303 | MRPS35 | 60488 | RNAseq | 0.4471 | 0.0186 | |
| SRP159526 | MRPS35 | 60488 | RNAseq | 0.0768 | 0.7786 | |
| SRP193095 | MRPS35 | 60488 | RNAseq | -0.0991 | 0.5895 | |
| SRP219564 | MRPS35 | 60488 | RNAseq | -0.0887 | 0.7158 | |
| TCGA | MRPS35 | 60488 | RNAseq | 0.0605 | 0.2511 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPS35 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPS35:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPS35 | 60488 | 11 | 1 | 18 | |
| GSE20123 | MRPS35 | 60488 | 11 | 1 | 18 | |
| GSE43470 | MRPS35 | 60488 | 10 | 4 | 29 | |
| GSE46452 | MRPS35 | 60488 | 10 | 1 | 48 | |
| GSE47630 | MRPS35 | 60488 | 13 | 0 | 27 | |
| GSE54993 | MRPS35 | 60488 | 0 | 9 | 61 | |
| GSE54994 | MRPS35 | 60488 | 11 | 2 | 40 | |
| GSE60625 | MRPS35 | 60488 | 0 | 1 | 10 | |
| GSE74703 | MRPS35 | 60488 | 9 | 3 | 24 | |
| GSE74704 | MRPS35 | 60488 | 6 | 1 | 13 | |
| TCGA | MRPS35 | 60488 | 44 | 6 | 46 |
Total number of gains: 125; Total number of losses: 29; Total Number of normals: 334.
Somatic mutations of MRPS35:
Generating mutation plots.
Highly correlated genes for MRPS35:
Showing top 20/893 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPS35 | MED15 | 0.772288 | 3 | 0 | 3 |
| MRPS35 | CLEC12A | 0.768708 | 3 | 0 | 3 |
| MRPS35 | LAP3 | 0.758295 | 3 | 0 | 3 |
| MRPS35 | AP3M1 | 0.737076 | 3 | 0 | 3 |
| MRPS35 | ACSS3 | 0.73475 | 3 | 0 | 3 |
| MRPS35 | TAS2R19 | 0.727785 | 3 | 0 | 3 |
| MRPS35 | ERLIN2 | 0.7255 | 3 | 0 | 3 |
| MRPS35 | DNMBP | 0.724022 | 3 | 0 | 3 |
| MRPS35 | DTWD1 | 0.719663 | 4 | 0 | 4 |
| MRPS35 | SOX18 | 0.71913 | 3 | 0 | 3 |
| MRPS35 | DCTN6 | 0.719101 | 3 | 0 | 3 |
| MRPS35 | PDE8A | 0.71838 | 3 | 0 | 3 |
| MRPS35 | PSMA5 | 0.716972 | 6 | 0 | 5 |
| MRPS35 | UQCRFS1 | 0.716216 | 4 | 0 | 4 |
| MRPS35 | TSEN15 | 0.716022 | 3 | 0 | 3 |
| MRPS35 | ALDOC | 0.714862 | 3 | 0 | 3 |
| MRPS35 | APIP | 0.714344 | 3 | 0 | 3 |
| MRPS35 | NDUFB6 | 0.712631 | 3 | 0 | 3 |
| MRPS35 | TP53I13 | 0.710702 | 3 | 0 | 3 |
| MRPS35 | ZHX2 | 0.703311 | 4 | 0 | 3 |
For details and further investigation, click here
