| Full name: coenzyme Q7, hydroxylase | Alias Symbol: CLK-1|CAT5 | ||
| Type: protein-coding gene | Cytoband: 16p12.3 | ||
| Entrez ID: 10229 | HGNC ID: HGNC:2244 | Ensembl Gene: ENSG00000167186 | OMIM ID: 601683 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COQ7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COQ7 | 10229 | 209746_s_at | 0.1989 | 0.6987 | |
| GSE20347 | COQ7 | 10229 | 210820_x_at | 0.3663 | 0.0063 | |
| GSE23400 | COQ7 | 10229 | 210820_x_at | 0.1292 | 0.0003 | |
| GSE26886 | COQ7 | 10229 | 209745_at | -0.4065 | 0.0347 | |
| GSE29001 | COQ7 | 10229 | 210820_x_at | 0.4707 | 0.0782 | |
| GSE38129 | COQ7 | 10229 | 209746_s_at | 0.3586 | 0.0109 | |
| GSE45670 | COQ7 | 10229 | 209746_s_at | 0.3372 | 0.0019 | |
| GSE53622 | COQ7 | 10229 | 24791 | -0.4237 | 0.0000 | |
| GSE53624 | COQ7 | 10229 | 24791 | -0.1318 | 0.0758 | |
| GSE63941 | COQ7 | 10229 | 210820_x_at | 1.1135 | 0.0035 | |
| GSE77861 | COQ7 | 10229 | 209745_at | -0.1041 | 0.4906 | |
| GSE97050 | COQ7 | 10229 | A_24_P398972 | -0.4915 | 0.2037 | |
| SRP007169 | COQ7 | 10229 | RNAseq | 0.2253 | 0.6406 | |
| SRP008496 | COQ7 | 10229 | RNAseq | 0.5426 | 0.0559 | |
| SRP064894 | COQ7 | 10229 | RNAseq | -0.1180 | 0.4091 | |
| SRP133303 | COQ7 | 10229 | RNAseq | 0.0571 | 0.7954 | |
| SRP159526 | COQ7 | 10229 | RNAseq | -0.0111 | 0.9675 | |
| SRP193095 | COQ7 | 10229 | RNAseq | -0.1701 | 0.0183 | |
| SRP219564 | COQ7 | 10229 | RNAseq | -0.1792 | 0.6612 | |
| TCGA | COQ7 | 10229 | RNAseq | -0.2310 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by COQ7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COQ7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COQ7 | 10229 | 5 | 3 | 22 | |
| GSE20123 | COQ7 | 10229 | 5 | 2 | 23 | |
| GSE43470 | COQ7 | 10229 | 3 | 3 | 37 | |
| GSE46452 | COQ7 | 10229 | 38 | 1 | 20 | |
| GSE47630 | COQ7 | 10229 | 11 | 6 | 23 | |
| GSE54993 | COQ7 | 10229 | 3 | 5 | 62 | |
| GSE54994 | COQ7 | 10229 | 3 | 10 | 40 | |
| GSE60625 | COQ7 | 10229 | 4 | 0 | 7 | |
| GSE74703 | COQ7 | 10229 | 3 | 2 | 31 | |
| GSE74704 | COQ7 | 10229 | 2 | 1 | 17 | |
| TCGA | COQ7 | 10229 | 20 | 12 | 64 |
Total number of gains: 97; Total number of losses: 45; Total Number of normals: 346.
Somatic mutations of COQ7:
Generating mutation plots.
Highly correlated genes for COQ7:
Showing top 20/346 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COQ7 | PIGX | 0.775846 | 3 | 0 | 3 |
| COQ7 | KIAA1324L | 0.762779 | 3 | 0 | 3 |
| COQ7 | DBT | 0.732955 | 3 | 0 | 3 |
| COQ7 | TYW3 | 0.722632 | 3 | 0 | 3 |
| COQ7 | CADM2 | 0.711864 | 3 | 0 | 3 |
| COQ7 | ZNF383 | 0.708436 | 3 | 0 | 3 |
| COQ7 | DAG1 | 0.708079 | 4 | 0 | 4 |
| COQ7 | C1orf131 | 0.69185 | 3 | 0 | 3 |
| COQ7 | KDM3B | 0.689796 | 3 | 0 | 3 |
| COQ7 | PCGF6 | 0.679001 | 3 | 0 | 3 |
| COQ7 | DCAF8 | 0.675279 | 4 | 0 | 4 |
| COQ7 | ZNF354C | 0.669794 | 4 | 0 | 4 |
| COQ7 | MRPL38 | 0.668983 | 3 | 0 | 3 |
| COQ7 | NUDT16 | 0.666428 | 3 | 0 | 3 |
| COQ7 | MED21 | 0.663627 | 3 | 0 | 3 |
| COQ7 | SCAI | 0.662746 | 4 | 0 | 3 |
| COQ7 | KIF5C | 0.661701 | 4 | 0 | 4 |
| COQ7 | CHCHD4 | 0.661057 | 3 | 0 | 3 |
| COQ7 | SNUPN | 0.660102 | 4 | 0 | 4 |
| COQ7 | HIGD2A | 0.660092 | 5 | 0 | 4 |
For details and further investigation, click here
