ARID2

 

Full name: AT-rich interaction domain 2 Alias Symbol: KIAA1557|DKFZp686G052|FLJ30619|BAF200
Type: protein-coding gene Cytoband: 12q12
Entrez ID: 196528 HGNC ID: HGNC:18037 Ensembl Gene: ENSG00000189079 OMIM ID: 609539
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 74/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ARID2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ARID2 196528 225490_at 0.1545 0.7999
GSE26886 ARID2 196528 225490_at 0.3499 0.0717
GSE45670 ARID2 196528 225490_at 0.1707 0.2327
GSE53622 ARID2 196528 76572 -0.3184 0.0006
GSE53624 ARID2 196528 76572 -0.2454 0.0203
GSE77861 ARID2 196528 225490_at 0.3977 0.0792
GSE97050 ARID2 196528 A_32_P74955 -0.3045 0.2370
SRP008496 ARID2 196528 RNAseq 0.2855 0.0848
SRP064894 ARID2 196528 RNAseq -0.3832 0.0516
SRP133303 ARID2 196528 RNAseq 0.2072 0.1822
SRP159526 ARID2 196528 RNAseq -0.0036 0.9840
SRP193095 ARID2 196528 RNAseq -0.0817 0.2669
SRP219564 ARID2 196528 RNAseq -0.1570 0.6405
TCGA ARID2 196528 RNAseq -0.0539 0.2660

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ARID2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ARID2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ARID2 196528 6 1 23
GSE20123 ARID2 196528 6 1 23
GSE43470 ARID2 196528 3 1 39
GSE46452 ARID2 196528 8 1 50
GSE47630 ARID2 196528 11 2 27
GSE54993 ARID2 196528 0 6 64
GSE54994 ARID2 196528 7 1 45
GSE60625 ARID2 196528 0 0 11
GSE74703 ARID2 196528 3 1 32
GSE74704 ARID2 196528 3 1 16
TCGA ARID2 196528 16 13 67

Total number of gains: 63; Total number of losses: 28; Total Number of normals: 397.  

 

Somatic mutations of ARID2:

 

Generating mutation plots.

 

Highly correlated genes for ARID2:

 

Showing top 20/424 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ARID2DNAJC130.824393303
ARID2GRIN2D0.8109303
ARID2ZNF1400.807276303
ARID2TRIM80.798398303
ARID2EIF5B0.786685303
ARID2ZXDC0.77973303
ARID2DFFA0.777729303
ARID2PHF200.776059303
ARID2CSNK2A20.771677303
ARID2ARL60.764209303
ARID2ZNF5860.762152303
ARID2SPEN0.757229303
ARID2FAM32A0.753673303
ARID2ATG4C0.752802303
ARID2CEP3500.75169404
ARID2TBC1D22B0.75091303
ARID2PMF10.746266303
ARID2BRD20.745179303
ARID2LRRC470.741354403
ARID2EPG50.736741303

For details and further investigation, click here