| Full name: coiled-coil-helix-coiled-coil-helix domain containing 4 | Alias Symbol: FLJ31709|TIMM40|MIA40 | ||
| Type: protein-coding gene | Cytoband: 3p25.1 | ||
| Entrez ID: 131474 | HGNC ID: HGNC:26467 | Ensembl Gene: ENSG00000163528 | OMIM ID: 611077 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CHCHD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHCHD4 | 131474 | 229595_at | -0.0667 | 0.7724 | |
| GSE26886 | CHCHD4 | 131474 | 229595_at | -0.6171 | 0.0011 | |
| GSE45670 | CHCHD4 | 131474 | 229595_at | -0.0890 | 0.4533 | |
| GSE53622 | CHCHD4 | 131474 | 130375 | -0.4157 | 0.0000 | |
| GSE53624 | CHCHD4 | 131474 | 130375 | -0.1052 | 0.2157 | |
| GSE63941 | CHCHD4 | 131474 | 229595_at | 0.4367 | 0.2857 | |
| GSE77861 | CHCHD4 | 131474 | 229595_at | -0.0210 | 0.9321 | |
| GSE97050 | CHCHD4 | 131474 | A_23_P428849 | -0.3291 | 0.3265 | |
| SRP007169 | CHCHD4 | 131474 | RNAseq | -0.7065 | 0.1189 | |
| SRP008496 | CHCHD4 | 131474 | RNAseq | -0.5611 | 0.0931 | |
| SRP064894 | CHCHD4 | 131474 | RNAseq | -0.1501 | 0.4332 | |
| SRP133303 | CHCHD4 | 131474 | RNAseq | -0.1448 | 0.4020 | |
| SRP159526 | CHCHD4 | 131474 | RNAseq | -0.1816 | 0.6445 | |
| SRP193095 | CHCHD4 | 131474 | RNAseq | -0.3235 | 0.0124 | |
| SRP219564 | CHCHD4 | 131474 | RNAseq | -0.4850 | 0.2540 | |
| TCGA | CHCHD4 | 131474 | RNAseq | -0.1418 | 0.0258 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CHCHD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHCHD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHCHD4 | 131474 | 2 | 17 | 11 | |
| GSE20123 | CHCHD4 | 131474 | 2 | 17 | 11 | |
| GSE43470 | CHCHD4 | 131474 | 0 | 21 | 22 | |
| GSE46452 | CHCHD4 | 131474 | 2 | 17 | 40 | |
| GSE47630 | CHCHD4 | 131474 | 2 | 23 | 15 | |
| GSE54993 | CHCHD4 | 131474 | 6 | 1 | 63 | |
| GSE54994 | CHCHD4 | 131474 | 1 | 32 | 20 | |
| GSE60625 | CHCHD4 | 131474 | 5 | 0 | 6 | |
| GSE74703 | CHCHD4 | 131474 | 0 | 17 | 19 | |
| GSE74704 | CHCHD4 | 131474 | 1 | 10 | 9 | |
| TCGA | CHCHD4 | 131474 | 2 | 68 | 26 |
Total number of gains: 23; Total number of losses: 223; Total Number of normals: 242.
Somatic mutations of CHCHD4:
Generating mutation plots.
Highly correlated genes for CHCHD4:
Showing top 20/255 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHCHD4 | DNAJA2 | 0.79737 | 3 | 0 | 3 |
| CHCHD4 | TMEM167A | 0.765024 | 3 | 0 | 3 |
| CHCHD4 | MON1A | 0.757385 | 3 | 0 | 3 |
| CHCHD4 | FBXO9 | 0.748814 | 3 | 0 | 3 |
| CHCHD4 | VPS41 | 0.746731 | 3 | 0 | 3 |
| CHCHD4 | FBXW2 | 0.741761 | 3 | 0 | 3 |
| CHCHD4 | OXNAD1 | 0.741232 | 4 | 0 | 4 |
| CHCHD4 | PRMT2 | 0.72709 | 3 | 0 | 3 |
| CHCHD4 | EIF3I | 0.717379 | 3 | 0 | 3 |
| CHCHD4 | CRK | 0.709323 | 4 | 0 | 3 |
| CHCHD4 | UBR3 | 0.707489 | 3 | 0 | 3 |
| CHCHD4 | IK | 0.705035 | 4 | 0 | 4 |
| CHCHD4 | LANCL2 | 0.701356 | 3 | 0 | 3 |
| CHCHD4 | AKIRIN1 | 0.700406 | 3 | 0 | 3 |
| CHCHD4 | TTC23 | 0.697042 | 3 | 0 | 3 |
| CHCHD4 | KBTBD8 | 0.694343 | 3 | 0 | 3 |
| CHCHD4 | TRIP11 | 0.690795 | 3 | 0 | 3 |
| CHCHD4 | CLTA | 0.689589 | 3 | 0 | 3 |
| CHCHD4 | ZCCHC10 | 0.688831 | 3 | 0 | 3 |
| CHCHD4 | WDR47 | 0.688257 | 3 | 0 | 3 |
For details and further investigation, click here
