| Full name: fumarate hydratase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q43 | ||
| Entrez ID: 2271 | HGNC ID: HGNC:3700 | Ensembl Gene: ENSG00000091483 | OMIM ID: 136850 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FH | 2271 | 214170_x_at | 0.2555 | 0.4136 | |
| GSE20347 | FH | 2271 | 214170_x_at | -0.1279 | 0.4781 | |
| GSE23400 | FH | 2271 | 214170_x_at | 0.0817 | 0.1844 | |
| GSE26886 | FH | 2271 | 214170_x_at | 0.3110 | 0.1419 | |
| GSE29001 | FH | 2271 | 214170_x_at | -0.1564 | 0.5679 | |
| GSE38129 | FH | 2271 | 214170_x_at | -0.0048 | 0.9735 | |
| GSE45670 | FH | 2271 | 203033_x_at | 0.0937 | 0.3891 | |
| GSE53622 | FH | 2271 | 123434 | -0.1860 | 0.0092 | |
| GSE53624 | FH | 2271 | 123434 | -0.0387 | 0.6889 | |
| GSE63941 | FH | 2271 | 214170_x_at | 0.1819 | 0.6159 | |
| GSE77861 | FH | 2271 | 203033_x_at | -0.1130 | 0.6149 | |
| GSE97050 | FH | 2271 | A_23_P34733 | -0.0694 | 0.8221 | |
| SRP007169 | FH | 2271 | RNAseq | -0.6722 | 0.0463 | |
| SRP008496 | FH | 2271 | RNAseq | -0.5428 | 0.0560 | |
| SRP064894 | FH | 2271 | RNAseq | 0.0295 | 0.8435 | |
| SRP133303 | FH | 2271 | RNAseq | 0.1643 | 0.3201 | |
| SRP159526 | FH | 2271 | RNAseq | 0.1095 | 0.7171 | |
| SRP193095 | FH | 2271 | RNAseq | -0.4356 | 0.0002 | |
| SRP219564 | FH | 2271 | RNAseq | -0.0425 | 0.9219 | |
| TCGA | FH | 2271 | RNAseq | -0.0503 | 0.2818 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FH | 2271 | 7 | 1 | 22 | |
| GSE20123 | FH | 2271 | 7 | 1 | 22 | |
| GSE43470 | FH | 2271 | 6 | 1 | 36 | |
| GSE46452 | FH | 2271 | 4 | 2 | 53 | |
| GSE47630 | FH | 2271 | 15 | 0 | 25 | |
| GSE54993 | FH | 2271 | 0 | 6 | 64 | |
| GSE54994 | FH | 2271 | 17 | 0 | 36 | |
| GSE60625 | FH | 2271 | 0 | 0 | 11 | |
| GSE74703 | FH | 2271 | 6 | 1 | 29 | |
| GSE74704 | FH | 2271 | 2 | 0 | 18 | |
| TCGA | FH | 2271 | 43 | 4 | 49 |
Total number of gains: 107; Total number of losses: 16; Total Number of normals: 365.
Somatic mutations of FH:
Generating mutation plots.
Highly correlated genes for FH:
Showing top 20/457 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FH | CPT1A | 0.802107 | 3 | 0 | 3 |
| FH | CEP192 | 0.778162 | 3 | 0 | 3 |
| FH | NOLC1 | 0.773779 | 3 | 0 | 3 |
| FH | SPCS2 | 0.76097 | 3 | 0 | 3 |
| FH | LRRC28 | 0.760888 | 3 | 0 | 3 |
| FH | PIGX | 0.756892 | 4 | 0 | 4 |
| FH | CLNS1A | 0.749185 | 3 | 0 | 3 |
| FH | TOMM40L | 0.748433 | 3 | 0 | 3 |
| FH | MCMBP | 0.748205 | 3 | 0 | 3 |
| FH | ZNF607 | 0.747782 | 3 | 0 | 3 |
| FH | CCNJ | 0.743455 | 3 | 0 | 3 |
| FH | MBTPS2 | 0.733686 | 3 | 0 | 3 |
| FH | MRPS14 | 0.733646 | 3 | 0 | 3 |
| FH | PPP2R2D | 0.732381 | 3 | 0 | 3 |
| FH | PSMG3 | 0.731602 | 4 | 0 | 4 |
| FH | MYOM2 | 0.729429 | 3 | 0 | 3 |
| FH | SENP5 | 0.726005 | 3 | 0 | 3 |
| FH | PPM1B | 0.722586 | 3 | 0 | 3 |
| FH | TTL | 0.722468 | 3 | 0 | 3 |
| FH | RBM26 | 0.719729 | 3 | 0 | 3 |
For details and further investigation, click here
