| Full name: metadherin | Alias Symbol: LYRIC|3D3|AEG-1 | ||
| Type: protein-coding gene | Cytoband: 8q22.1 | ||
| Entrez ID: 92140 | HGNC ID: HGNC:29608 | Ensembl Gene: ENSG00000147649 | OMIM ID: 610323 |
| Drug and gene relationship at DGIdb | |||
Expression of MTDH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MTDH | 92140 | 212251_at | 0.8046 | 0.1223 | |
| GSE20347 | MTDH | 92140 | 212251_at | 0.5798 | 0.0007 | |
| GSE23400 | MTDH | 92140 | 212251_at | 0.8044 | 0.0000 | |
| GSE26886 | MTDH | 92140 | 212251_at | 0.5916 | 0.0166 | |
| GSE29001 | MTDH | 92140 | 212251_at | 0.3451 | 0.2446 | |
| GSE38129 | MTDH | 92140 | 212251_at | 0.5760 | 0.0000 | |
| GSE45670 | MTDH | 92140 | 212251_at | 0.4980 | 0.0042 | |
| GSE53622 | MTDH | 92140 | 58196 | 0.4095 | 0.0000 | |
| GSE53624 | MTDH | 92140 | 58196 | 0.6142 | 0.0000 | |
| GSE63941 | MTDH | 92140 | 212251_at | -0.8077 | 0.1380 | |
| GSE77861 | MTDH | 92140 | 212250_at | 0.1578 | 0.3907 | |
| GSE97050 | MTDH | 92140 | A_33_P3234168 | 0.5182 | 0.1399 | |
| SRP007169 | MTDH | 92140 | RNAseq | -0.3487 | 0.2218 | |
| SRP008496 | MTDH | 92140 | RNAseq | -0.0289 | 0.8720 | |
| SRP064894 | MTDH | 92140 | RNAseq | 0.6400 | 0.0001 | |
| SRP133303 | MTDH | 92140 | RNAseq | 0.4529 | 0.0000 | |
| SRP159526 | MTDH | 92140 | RNAseq | 0.1761 | 0.5845 | |
| SRP193095 | MTDH | 92140 | RNAseq | 0.2305 | 0.0151 | |
| SRP219564 | MTDH | 92140 | RNAseq | 0.3114 | 0.2271 | |
| TCGA | MTDH | 92140 | RNAseq | 0.0874 | 0.0307 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MTDH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MTDH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MTDH | 92140 | 16 | 0 | 14 | |
| GSE20123 | MTDH | 92140 | 17 | 0 | 13 | |
| GSE43470 | MTDH | 92140 | 21 | 1 | 21 | |
| GSE46452 | MTDH | 92140 | 23 | 0 | 36 | |
| GSE47630 | MTDH | 92140 | 24 | 0 | 16 | |
| GSE54993 | MTDH | 92140 | 0 | 20 | 50 | |
| GSE54994 | MTDH | 92140 | 34 | 2 | 17 | |
| GSE60625 | MTDH | 92140 | 0 | 4 | 7 | |
| GSE74703 | MTDH | 92140 | 18 | 1 | 17 | |
| GSE74704 | MTDH | 92140 | 12 | 0 | 8 | |
| TCGA | MTDH | 92140 | 55 | 2 | 39 |
Total number of gains: 220; Total number of losses: 30; Total Number of normals: 238.
Somatic mutations of MTDH:
Generating mutation plots.
Highly correlated genes for MTDH:
Showing top 20/1328 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MTDH | HNRNPUL1 | 0.778356 | 3 | 0 | 3 |
| MTDH | PET117 | 0.769906 | 3 | 0 | 3 |
| MTDH | ZNF121 | 0.75684 | 4 | 0 | 4 |
| MTDH | C8orf82 | 0.743891 | 3 | 0 | 3 |
| MTDH | TP53RK | 0.73319 | 3 | 0 | 3 |
| MTDH | KRTCAP2 | 0.726856 | 4 | 0 | 4 |
| MTDH | PUF60 | 0.721987 | 11 | 0 | 10 |
| MTDH | JKAMP | 0.718494 | 5 | 0 | 5 |
| MTDH | RBM26 | 0.718345 | 4 | 0 | 3 |
| MTDH | FAM89A | 0.716087 | 3 | 0 | 3 |
| MTDH | ANAPC4 | 0.714299 | 3 | 0 | 3 |
| MTDH | SLC25A29 | 0.714168 | 3 | 0 | 3 |
| MTDH | ZNF764 | 0.708252 | 3 | 0 | 3 |
| MTDH | ZNF707 | 0.703847 | 3 | 0 | 3 |
| MTDH | ZNF736 | 0.702957 | 3 | 0 | 3 |
| MTDH | ZNF250 | 0.702462 | 4 | 0 | 3 |
| MTDH | TATDN1 | 0.702337 | 8 | 0 | 8 |
| MTDH | ENY2 | 0.701036 | 13 | 0 | 12 |
| MTDH | MRPS28 | 0.700522 | 10 | 0 | 9 |
| MTDH | DHX36 | 0.696706 | 7 | 0 | 6 |
For details and further investigation, click here
