| Full name: anaphase promoting complex subunit 4 | Alias Symbol: APC4 | ||
| Type: protein-coding gene | Cytoband: 4p15.2 | ||
| Entrez ID: 29945 | HGNC ID: HGNC:19990 | Ensembl Gene: ENSG00000053900 | OMIM ID: 606947 |
| Drug and gene relationship at DGIdb | |||
ANAPC4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation | |
| hsa05166 | HTLV-I infection |
Expression of ANAPC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANAPC4 | 29945 | 226917_s_at | 0.1589 | 0.8158 | |
| GSE26886 | ANAPC4 | 29945 | 226917_s_at | 0.4753 | 0.0935 | |
| GSE45670 | ANAPC4 | 29945 | 226917_s_at | 0.0181 | 0.9029 | |
| GSE53622 | ANAPC4 | 29945 | 122178 | -0.1016 | 0.0851 | |
| GSE53624 | ANAPC4 | 29945 | 122178 | -0.2384 | 0.0000 | |
| GSE63941 | ANAPC4 | 29945 | 226917_s_at | -0.3530 | 0.3969 | |
| GSE77861 | ANAPC4 | 29945 | 232524_x_at | -0.1001 | 0.7782 | |
| GSE97050 | ANAPC4 | 29945 | A_23_P317800 | -0.2007 | 0.3408 | |
| SRP007169 | ANAPC4 | 29945 | RNAseq | 0.0354 | 0.9364 | |
| SRP008496 | ANAPC4 | 29945 | RNAseq | 0.1379 | 0.6089 | |
| SRP064894 | ANAPC4 | 29945 | RNAseq | 0.2033 | 0.2612 | |
| SRP133303 | ANAPC4 | 29945 | RNAseq | -0.1948 | 0.1555 | |
| SRP159526 | ANAPC4 | 29945 | RNAseq | -0.2954 | 0.2048 | |
| SRP193095 | ANAPC4 | 29945 | RNAseq | -0.2461 | 0.0037 | |
| SRP219564 | ANAPC4 | 29945 | RNAseq | 0.2217 | 0.5555 | |
| TCGA | ANAPC4 | 29945 | RNAseq | -0.0489 | 0.3732 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ANAPC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANAPC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANAPC4 | 29945 | 0 | 18 | 12 | |
| GSE20123 | ANAPC4 | 29945 | 0 | 17 | 13 | |
| GSE43470 | ANAPC4 | 29945 | 0 | 15 | 28 | |
| GSE46452 | ANAPC4 | 29945 | 1 | 36 | 22 | |
| GSE47630 | ANAPC4 | 29945 | 1 | 19 | 20 | |
| GSE54993 | ANAPC4 | 29945 | 10 | 0 | 60 | |
| GSE54994 | ANAPC4 | 29945 | 5 | 11 | 37 | |
| GSE60625 | ANAPC4 | 29945 | 0 | 0 | 11 | |
| GSE74703 | ANAPC4 | 29945 | 0 | 13 | 23 | |
| GSE74704 | ANAPC4 | 29945 | 0 | 11 | 9 | |
| TCGA | ANAPC4 | 29945 | 11 | 47 | 38 |
Total number of gains: 28; Total number of losses: 187; Total Number of normals: 273.
Somatic mutations of ANAPC4:
Generating mutation plots.
Highly correlated genes for ANAPC4:
Showing top 20/250 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANAPC4 | METTL3 | 0.871038 | 3 | 0 | 3 |
| ANAPC4 | S100PBP | 0.849808 | 3 | 0 | 3 |
| ANAPC4 | UFM1 | 0.844068 | 3 | 0 | 3 |
| ANAPC4 | METTL5 | 0.843369 | 3 | 0 | 3 |
| ANAPC4 | LRRC40 | 0.835394 | 3 | 0 | 3 |
| ANAPC4 | PPIG | 0.826118 | 3 | 0 | 3 |
| ANAPC4 | ZC3H15 | 0.819426 | 3 | 0 | 3 |
| ANAPC4 | TTF1 | 0.817631 | 3 | 0 | 3 |
| ANAPC4 | TBCA | 0.814455 | 3 | 0 | 3 |
| ANAPC4 | PDHX | 0.812691 | 3 | 0 | 3 |
| ANAPC4 | CWC22 | 0.795907 | 3 | 0 | 3 |
| ANAPC4 | TBP | 0.789334 | 3 | 0 | 3 |
| ANAPC4 | CELF1 | 0.787167 | 3 | 0 | 3 |
| ANAPC4 | COCH | 0.782616 | 3 | 0 | 3 |
| ANAPC4 | TBRG1 | 0.78246 | 3 | 0 | 3 |
| ANAPC4 | OLA1 | 0.780296 | 3 | 0 | 3 |
| ANAPC4 | NPHP3 | 0.779235 | 3 | 0 | 3 |
| ANAPC4 | ACSL4 | 0.778581 | 3 | 0 | 3 |
| ANAPC4 | CRLS1 | 0.771572 | 3 | 0 | 3 |
| ANAPC4 | SRSF1 | 0.771246 | 3 | 0 | 3 |
For details and further investigation, click here
